A5100326685- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- Protease and Inhibitor Mechanisms
- Proteoglycans and glycosaminoglycans research
- Nuclear Receptors and Signaling
- Endoplasmic Reticulum Stress and Disease
- Calcium signaling and nucleotide metabolism
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
- Galectins and Cancer Biology
- Cancer-related gene regulation
- Prostate Cancer Treatment and Research
Sichuan University
2024
Jiangsu Vocational College of Medicine
2020-2021
Hejian People's Hospital
2020
Huazhong University of Science and Technology
2017
Wuhan No.1 Hospital
2017
Mudanjiang Medical University
2016
China Pharmaceutical University
2013
Long non-coding RNA (lncRNA) XIST has been implicated in the progression of a variety tumor diseases. The purpose this study was to explore molecular role lncRNA human hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).
Endoplasmic reticulum (ER) stress arises when excessive improperly folded proteins accumulate in the ER lumen. When occurs, unfolded protein response (UPR) is subsequently activated to restore proteostasis. However, severe leads apoptosis. Recent studies have suggested that cisplatin cytotoxicity may be related stress. The purpose of this study was determine whether participates cochlear cell apoptosis a cisplatin-induced ototoxicity rat model and also possible relationship between hearing...
The study is aimed at investigating the regulatory relationship between miR-145-5p and ABRACL, has tried clarifying mechanisms underlying proliferation, migration, invasion of esophageal carcinoma (EC) cells.Gene expression data related to EC were accessed from TCGA database, "edgeR" package was used screen differentially expressed genes. TargetScan, miRDB, miRTarBase databases predict potential targets for target miRNA miR-145-5p. qRT-PCR Western blot performed assess ABRACL in cells....
Background: Recent researches have shown that long non-coding RNA (LncRNA) is often disordered and acts in many carcinomas. Clear cell renal carcinoma (ccRCC) the main reason for carcinoma-related deaths, which are mainly caused by metastasis. HCP5 a newly discovered LcnRNA. Early studies found neoplasm metastasis, but mechanism of ccRCC still unclear. Methods: The expression human (RCC) was detected real-time quantitative PCR. biological effect LncRNAs proliferation, migration, invasion...
Quantum chemistry calculations together with modeling of ligand–water exchange reactions are used to investigate, for the first time, interaction mechanisms between emodin anthraquinones and catalytic zinc ion in matrix metalloproteinases (MMPs), coordinating mode them is determined. The indicate that electron transfer from molecule MMPs occurs when coordinates O atoms substituent groups at various positions molecule, more number atom group ion, stronger ability them. It found comparing...
Cyclin B2 (CCNB2), a member of the cyclin protein family, has key role in progression G2/M transition. However, clinical value CCNB2 hepatocellular carcinoma (HCC) is still unknown. The aim our study to identify HCC patients. Immunohistochemical analysis using tissue microarray (TMA) was employed evaluate expression and correlation between clinicopathological features relationship prognosis patients analyzed Oncomine Kaplan-Meier Plotter online resources. High cytoplasmic observed 77.22%...
Abstract Background: The study aimed to investigate the regulatory relationship between miR-145-5p and ABRACL, tried clarify mechanisms underlying proliferation, migration invasion of esophageal cancer (EC) cells. Methods: Gene expression data related EC were accessed from TCGA database “edgeR” package was used screen differentially expressed miRNA (DEmiRNAs) genes (DEGs). TargetScan, miRDB miRTarBase databases predict potential targets for target miR-145-5p. qRT-PCR Western blot performed...
Abstract Background Recent studies have discovered that lncRNAs regulate lipoprotein (LP) (a)-mediated endothelial progenitor cells (EPCs) damage through sponging miRNAs. However, the role of XIST in EPC remains unknown. Method: Firstly, LP(a)(100 ng/mL) was used to treat EPCs for 6 hours. Then, apoptosis, proliferation, migration, adhesion, angiogenesis were detected. Moreover, overexpression or miR-126 on built. Mechanistically, bioinformatics database, dual-luciferase reporter assay and...