A5030146005- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Immune Cell Function and Interaction
- Connexins and lens biology
- T-cell and B-cell Immunology
- HIV Research and Treatment
- Ultrasound and Hyperthermia Applications
- Advancements in Battery Materials
- Radiopharmaceutical Chemistry and Applications
- Boron Compounds in Chemistry
- Nanoparticle-Based Drug Delivery
- Advanced Chemical Sensor Technologies
- Molecular Sensors and Ion Detection
- Supramolecular Self-Assembly in Materials
- X-ray Diffraction in Crystallography
- Microbial Inactivation Methods
- Graphene and Nanomaterials Applications
- RNA regulation and disease
- Crystallization and Solubility Studies
- Boron and Carbon Nanomaterials Research
- Antimicrobial Peptides and Activities
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
The University of Melbourne
2020-2024
Peter Doherty Institute
2020-2024
Henan University
2023
First Affiliated Hospital of Guangdong Pharmaceutical University
2021
Zhengzhou University of Industrial Technology
2021
Australian Research Council
2020
University of Science and Technology of China
2016-2020
Hefei National Center for Physical Sciences at Nanoscale
2016-2020
Microscale (United States)
2016-2019
Hefei University
2016-2019
Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ express Vγ9Vδ2+ cell receptors (TCRs) that respond phosphoantigens (pAgs) produced by cellular pathogens and overexpressed cancers. However, the molecular targets recognized these γδTCRs unknown. Here, we identify butyrophilin 2A1 (BTN2A1) as a key ligand binds Vγ9+ TCR γ chain. BTN2A1 associates with another butyrophilin, BTN3A1, act together initiate responses pAg. Furthermore, binding of second ligand,...
Image-guided photothermal therapy (PTT) is an attractive strategy to improve the diagnosis accuracy and treatment outcomes by monitoring accumulation of agents in tumors real-time determining best window. Taking advantage superior imaging quality NIR-II fluorescence remote-controllable phototherapy modality PTT, we developed a facile macromolecular fluorophore (PF) conjugating small-molecule (Flav7) with amphiphilic polypeptide. The PF can form uniform micelles aqueous solution, which...
An efficient pH-responsive multifunctional polypeptide micelle for simultaneous imaging and in vitro photodynamic therapy (PDT) has been prepared. The goal here is to detect treat cancer cells by near-infrared fluorescence (NIRF) PDT synchronously. A photosensitizer BODIPY-Br2 with singlet oxygen generation was synthesized at first which owns both seductive abilities emission reactive species (ROS) under light irradiation. Then, amphiphilic copolymer micelles pH-triggered disassembly were...
Near infrared (NIR) imaging-guided photodynamic therapy (PDT) is attractive, especially the utilization of one dye as both a photosensitizer and fluorescent probe, as-synthesized BODIPY-Br2 molecule candidate. Here, galactose targeted amphiphilic copolymer polypeptide was synthesized its micelles work nanocarriers for BODIPY targeting NIR PDT hepatoma cancer cells. At same time, could light up cytoplasm real-time imaging kill cells when switched on. In vitro tests performed on HepG2 HeLa...
Oxygen self-sufficient fluorinated polypeptide nanoparticles have been synthesized <italic>via</italic> the loading of a NIR photosensitizer (BODIPY-Br<sub>2</sub>) into water-dispersible drug delivery system for high efficiency PDT.
Polypeptide micelles conjugated with DOX and a NIR photosensitizer can be used as imaging-guided PDT agents for cancer theranostics.
Cholesterol undergoes exchange between membranes containing sphingomyelin at a much slower rate than lacking sphingomyelin. To investigate the role of hydroxy group 3-position in interaction and cholesterol, we have measured rates [4-14C]cholesterol unilamellar vesicles prepared with N-stearoylsphingomyelin or synthetic analogues which is replaced an O-alkyl hydrogen. Vesicles from 3-deoxy- 3-O-methyl-N-stearoylsphingomyelin had same [14C]-cholesterol desorption. The half-times for...
MicroRNAs (miRNAs) regulate gene expression and may contribute to HIV‐1 infection. In this study, our goal was investigate the mechanisms by which miR‐34a influenced Tat‐induced transactivation through SIRT1/NFκB pathway. We showed that Tat induced up‐regulation of in TZM‐bl cells. MiR‐34a significantly inhibited SIRT1 expression. Overexpression increased LTR transactivation. Forced decreased protein consequently diminished acetylation p65, while treatment with a inhibitor had opposite...
A new substitution pattern of BF2 azadipyrromethene (azaBODIPY) dyes was obtained by phenanthrene fusion through a key palladium-catalyzed intramolecular C–H activation reaction. These [a]-phenanthrene-fused azaBODIPYs have near planar structure the phenanthrene-fused core in crystalline state. The chromophore absorbs (log ε > 5) and fluoresces (ϕ = 0.32–0.38) strongly above 700 nm with excellent photostability may be used as an attractive bright NIR bioimaging agent.
<bold>PEG-BDP</bold> macro-photosensitizer was synthesized which showed imaging-guided photodynamic therapy.
A carborane-containing triblock copolymer conjugated with a near infrared (NIR) fluorescence probe has been synthesized <italic>via</italic> reversible addition fragmentation chain transfer (RAFT), ring open polymerization (ROP), and conjugations of cyanine NIR dye.
NIR photosensitizer is attractive for photodynamic therapy (PDT). Low-power light irradiation and imaging-guided PDT makes it possible to increase tissue penetration depth. The pyrrole-substituted iodinated BODIPY (BDPI) molecule was designed synthesized, possesses an intense absorption emission band, exhibits a high singlet oxygen quantum yield (ΦΔ = 0.80) which leads remarkable cytotoxicity upon low power illumination (IC50 0.60 μg/mL, 6.1 mW/cm2). After being encapsulated with...
Chromatin remodeling, especially in relation to the transactivator Tat, is an essential event for human immunodeficiency virus-1 (HIV-1) transcription. Curcumin has been shown suppress pathways linked HIV-1 replication. We investigated whether curcumin had potential inhibit Tat-induced long terminal repeat region (LTR) transactivation. As we shown, inhibited LTR transcativation, while knockdown of histone deacetylase 1 (HDAC1) by siRNA potentiated transcativation. reversed down-regulation...
Ionizable tertiary amines functional polypeptide based micelles conjugated with NIR dye Cy5.5 and quencher have been synthesized, a strong fluorescence switch-on in the region under weak acidic conditions can be found, which is ultra-pH-sensitive.
Mannose conjugated polypeptide nanoparticles as a pH-responsive prodrug for enhanced near infrared imaging-guided photodynamic therapy.
Near-infrared (NIR) photodynamic therapy (PDT) is a promising antitumor strategy under NIR light irradiation to kill cancer cells. Mitochondria has critical function in sustaining cellular viability and death, which the ideal organelle for PDT. Here, we reported tetraphenylporphine (TPP)-conjugated amphiphilic copolymer an iodinated boron dipyrromethene photosensitizer (BDPI) with high singlet oxygen yield form nanoparticles (PBDPI-TPP), could realize mitochondria-targeting improve...