A5025287132- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Monoclonal and Polyclonal Antibodies Research
- Complement system in diseases
- Platelet Disorders and Treatments
- Xenotransplantation and immune response
- Migraine and Headache Studies
- Microscopic Colitis
- Neurological Complications and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Lymphatic Disorders and Treatments
- Vitamin D Research Studies
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Immune Response and Inflammation
- Chronic Lymphocytic Leukemia Research
- Vitamin C and Antioxidants Research
- Hemophilia Treatment and Research
- Trigeminal Neuralgia and Treatments
- Urticaria and Related Conditions
- Celiac Disease Research and Management
- Drug-Induced Adverse Reactions
- Antimicrobial Peptides and Activities
- Food Allergy and Anaphylaxis Research
CSL (Australia)
2018-2023
The University of Melbourne
2020
Chelsea and Westminster Hospital
1983
Leicester Royal Infirmary
1978-1981
King Edward VII Hospital
1974-1978
Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ express Vγ9Vδ2+ cell receptors (TCRs) that respond phosphoantigens (pAgs) produced by cellular pathogens and overexpressed cancers. However, the molecular targets recognized these γδTCRs unknown. Here, we identify butyrophilin 2A1 (BTN2A1) as a key ligand binds Vγ9+ TCR γ chain. BTN2A1 associates with another butyrophilin, BTN3A1, act together initiate responses pAg. Furthermore, binding of second ligand,...
Abstract Activation of Fc receptors and complement by immune complexes is a common important pathogenic trigger in many autoimmune diseases so blockade these innate pathways may be an attractive target for treatment complex-mediated pathomechanisms. High-dose IVIG used to treat inflammatory diseases, several studies demonstrate that the therapeutic effects can recapitulated with portion. Further, recent data indicate recombinant multimerized molecules exhibit potent anti-inflammatory...
Human complement receptor 1 (HuCR1) is a pivotal regulator of activity, acting on all three pathways as membrane-bound C3b/C4b, C3/C5 convertase decay accelerator, and cofactor for factor I-mediated cleavage C3b C4b. In this study, we sought to identify minimal soluble fragment HuCR1, which retains the regulatory activity wildtype protein. To end, generated recombinant, soluble, truncated versions HuCR1 compared their ability inhibit activation in vitro using multiple assays. A form at amino...
The table shows that the overall incidence of impotence was 23 % (19/83) among diabetics and 20% (10/50) non-diabetics.No differ- ence in libido emerged between groups.Of impotent men, 10 dia- betics four non-diabetics rarely or never experienced sexual desire whereas nine six often did.All subjects aged under 50 had "normal" libido, except for one diabetic 45.Incidence non-diabetic hospital outpatients Diabetics Non-diabetics Age No (years)
Hageman factor (FXII) is an essential component in the intrinsic coagulation cascade and a therapeutic target for prophylactic treatment of hereditary angioedema (HAE). CSL312 (garadacimab) novel high-affinity human antibody capable blocking activated FXII activity that currently undergoing Phase 3 clinical trials HAE. Structural studies using hydrogen/deuterium exchange coupled to mass spectrometry revealed evidence interaction between regions surrounding S1 specificity pocket FXII,...
We present two cases of adult coeliac disease whose major clinical feature was marked lymphadenopathy. One patient also displayed a peripheral lymphocytosis which varied with treatment the underlying disease.
Identical male twins are described, one of whom presented with clinical symptoms Addison's disease whereas the other was shown to have a deficient adrenal cortical response stimulation tests. Both had positive cortex antibodies.
Case reportA 56-year-old research engineer presented to the Hammersmith Hospital in 1972 with deteriorating balance, speech, and writing for nine months.Family history was negative.Examination showed titubation, slurred horizontal nystagmus, cerebellar ataxia arms, of gait.Tendon reflexes sensation were normal.A cervical myelogram vertebral arteriogram normal.Air encephalography slight dilatation third ventricle cerebral cortical sulci.Malignancy, hypothyroidism, other systemic diseases...
Abstract A novel mechanism for extending the circulatory half-life of coagulation factor VIII (FVIII) has been established and evaluated preclinically. The FVIII binding domain von Willebrand (D′D3) fused to human albumin (rD′D3-FP) dose dependently improved pharmacokinetics parameters coadministered in all animal species tested, from mouse cynomolgus monkey, after IV injection. At higher doses, recombinant (rVIII-SingleChain) was calculated be increased 2.6-fold fivefold compared with...
Abstract Humans have a minor lymphocyte population of gamma-delta (γδ) T cells. The majority these express recombined Vγ9Vδ2 cell receptor (TCR) attractive to immunotherapy. This distinct TCR conveys reactivity phosphorylated antigens (pAg) that derive from pathogens or accumulate inside tumour Such responses are regulated by butyrophilin (BTN) 3A1 and other membrane-related proteins present on antigen-presenting However, the activation mechanism direct molecular ligand recognised γδ remain...