A5022433710- Nanoparticle-Based Drug Delivery
- Fluid Dynamics Simulations and Interactions
- Ship Hydrodynamics and Maneuverability
- Transportation Planning and Optimization
- Catalytic Processes in Materials Science
- Advanced Photocatalysis Techniques
- Traffic control and management
- Boron Compounds in Chemistry
- Fluid Dynamics and Turbulent Flows
- Nanoplatforms for cancer theranostics
- Industrial Technology and Control Systems
- Traffic Prediction and Management Techniques
- Cavitation Phenomena in Pumps
- Probabilistic and Robust Engineering Design
- Cerebrospinal fluid and hydrocephalus
- Seismic Imaging and Inversion Techniques
- Computational Fluid Dynamics and Aerodynamics
- Spinal Dysraphism and Malformations
- Radiopharmaceutical Chemistry and Applications
- Acupuncture Treatment Research Studies
- Fish Ecology and Management Studies
- Geophysical and Geoelectrical Methods
- Protein purification and stability
- Healthcare and Venom Research
- Synthesis and properties of polymers
University of Idaho
2014-2024
Shandong Lianxing Energy Group (China)
2024
China Resources (China)
2019-2024
Regeneron (United States)
2019-2024
University of California, Berkeley
2024
American Pharmacists Association
2023
China State Shipbuilding (China)
2023
Beijing Friendship Hospital
2010-2022
Capital Medical University
2009-2022
Nanjing University of Aeronautics and Astronautics
2020-2022
A factor of safety method for quantitative estimates grid-spacing and time-step uncertainties solution verification is developed. It removes the two deficiencies grid convergence index correction methods, namely, unreasonably small uncertainty when estimated order accuracy using Richardson extrapolation greater than theoretical lack statistical evidence that interval at 95% confidence level bounds comparison error. Different error are evaluated effectivity index. The estimate builds on...
Photocatalytic oxidation of methane to methanol is an attractive process under mild conditions, nevertheless confronting significant challenges in achieving high conversion and selectivity simultaneously. Herein, we propose a strategy for the direct rapid generation hydroxyl radicals (•OH) from O2 (O2 → *OOH •OH) by rational design Au–Pd/ZnO photocatalyst, skipping water-soluble H2O2 avoiding diffusion. For photocatalytic at ambient temperature, yield CH3OH over optimized 1.0% AuPd0.5/ZnO...
Propylene oxide (PO) is an important raw material in the plastics industry. The propylene epoxidation using O2 without H2 and noble metals considered a fantasy reaction. Here we constructed tandem system for photocatalytic situ H2O2 production epoxidation. In this transformation system, prepared carbon nitride containing N3C vacancies one step by synergistic action of argon pyrolysis supramolecular self-assembly precursor. introduction significantly promoted photogenerated electron–hole...
Abstract Artificial photosynthesis of H 2 O from and by visible light is a promising approach, but the efficiency still unsatisfactory because inefficient adsorption proton supply. Here, terphenyl functionalized covalent triazine polymer (CTP‐TD) prepared for efficient production. Experimental theoretical results show that structure can promote regulating oxygen evolution (O → 1 ) improve supply accelerating water oxidation. The significantly promotes singlet ( production via intersystem...
Computational fluid dynamics for ship hydrodynamics has made monumental progress over the last ten years, which is reaching milestone of providing first-generation simulation-based design tools with vast capabilities model- and full-scale simulations optimization. This due to enabling technologies such as free surface tracking/capturing, turbulence modeling, 6 degree freedom (DoF) motion prediction, dynamic overset grids, local/adaptive grid refinement, high performance computing,...
Reduction-sensitive polymeric nanocarrier with near-infrared fluorescence probe has been prepared. Disulfide-cross-linked polypeptide nanogel property (NIRF nanogel) was first synthesized, then the anticancer drug doxorubicin encapsulated into core of NIRF to prepare a carrier prodrug). In vitro release study prodrug revealed an accelerated behavior in presence 10 mM glutathione (GSH). Cellular uptake studies both and showed that they could enter cell via endocytosis. With aid labeling,...
Intrathecal drug delivery has a significant role in pain management and central nervous system (CNS) disease therapeutics. A fluid-physics based tool to assist clinicians choosing specific doses the spine or brain may help improve treatment schedules.This study applied computational fluid dynamics (CFD) vitro model verification assess intrathecal an anatomically idealized of human CSF with key anatomic features CNS. Key parameters analyzed included (a) injection location including lumbar...
Abstract A novel disulfide core cross‐linked PEGylated polypeptide nanogel has been synthesized by a one‐step ring opening copolymerization of γ‐benzyl L ‐glutamate N ‐carboxyanhydride and ‐cystine using an amino group‐terminated poly(ethylene glycol) methyl ether as initiator. Characterization products confirms the formation with linkages size about 250 nm, these studies also confirm that this can easily be broken glutathione. Cell viability experiments show good biocompatibility...
Detection and quantitation of homodimer impurities in therapeutic bispecific antibody (bsAb) drug products is essential to support development quality control (QC) release. LC-MS-based techniques have been frequently applied for this analysis. However, sensitive detection low-abundance can still be challenging regular workflows, which largely due the lack chromatographic resolution between main bsAb species. Here, we report a novel analytical method, couples mixed-mode size exclusion...
The accuracy of LIBS coal quality detection was improved after ash classification.
Near-infrared light occupies 54.3% of the solar spectrum and has greater penetration depth, its effective utilization is great significance in practical application photocatalysis on a larger scale. However, development catalysts that can directly utilize near-infrared still huge challenge. This paper proposes strategy to (excitation wavelength extending 850 nm) by creating carbon material doped with high-spin-state Co(II)-Nx single-atom site. In near-infrared-light-irradiated photooxidation...
The hydrogenation of CO2 into high-value chemistry is seen as one the viable strategies for solving energy crisis future. Light olefins have attracted considerable attention basic feedstocks in industry. In this work, a series Fe–Co bimetallic active site catalysts were constructed by typical sol–gel strategy. synergistic regulation layout catalyst highly interfaces and exhibited high conversion (56.9%) CO2, low CO selectivity (3.6%), (40.5%) light olefins, remarkable yield (22.2%). results...
Cerebrospinal fluid (CSF) dynamics are thought to play a vital role in central nervous system (CNS) physiology. The objective of this study was investigate the impact spinal cord (SC) nerve roots (NR) on CSF dynamics. A subject-specific computational (CFD) model complete subarachnoid space (SSS) with and without anatomically realistic NR nonuniform moving dura wall deformation constructed. This CFD allowed detailed investigation velocities that is not possible vivo using magnetic resonance...
A carborane-containing triblock copolymer conjugated with a near infrared (NIR) fluorescence probe has been synthesized <italic>via</italic> reversible addition fragmentation chain transfer (RAFT), ring open polymerization (ROP), and conjugations of cyanine NIR dye.
Assessment of critical quality attributes (CQAs) is an important aspect during the development therapeutic monoclonal antibodies (mAbs). Attributes that affect either target binding or Fc receptor engagement may have direct impacts on drug safety and efficacy thus are considered as CQAs. Native size exclusion chromatography (SEC)-based competitive assay has recently been reported demonstrated significant benefits compared to conventional approaches for CQA identification, owing its faster...
Novel carborane polyimides were synthesized and studied. Aromatic meta-carborane diamines of different structures initially prepared. Polymerization these new with the commercially available 4,4′-oxydiphthalic dianhydride led to various thermal properties. The amorphous polymers obtained are moderate molecular weight show good solubility in organic solvents. Thermal analyses reveal that they have ultrahigh stability depending on their specific structures, 5% decomposition temperatures...
LC–MS based analysis of protein biopharmaceuticals could benefit from improved data quality, which can subsequently lead to drug characterization with higher confidence and less ambiguity. In this study, we created a simple device modify the desolvation gas on Q-Exactive mass spectrometer demonstrate utility in improving both peptide mapping intact analysis, two most routinely widely applied techniques biopharmaceutical characterization. By modifying acid vapor propionic (PA) isopropanol...
Here we report the syntheses of polyimides with meta-carborane cages embedded in polymer chain and their characterizations. Aromatic carborane diamines were prepared by a Sonogashira reaction first place; obtained commercially available dianhydride led to formation high molecular weight. Thermogravimetric analysis (TGA) samples showed that they have excellent thermal stability, 5 wt% decomposition temperatures (Td5%) higher than 520 °C. Due boron-rich nature polyimides, here potential...