A5015069711- interferon and immune responses
- Tuberculosis Research and Epidemiology
- Autophagy in Disease and Therapy
- Biochemical and Molecular Research
- NF-κB Signaling Pathways
- Vibrio bacteria research studies
- HIV Research and Treatment
- Bacterial biofilms and quorum sensing
- Protein Tyrosine Phosphatases
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Cancer Cells and Metastasis
- Gut microbiota and health
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Reproductive System and Pregnancy
- Neonatal Health and Biochemistry
- Cell death mechanisms and regulation
- Ion Transport and Channel Regulation
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Pneumonia and Respiratory Infections
- Exercise and Physiological Responses
- Medical and Biological Ozone Research
- Antibiotic Resistance in Bacteria
Chinese Academy of Sciences
2015-2025
Czech Academy of Sciences, Institute of Microbiology
2020-2025
Institute of Microbiology
2014-2024
University of Chinese Academy of Sciences
2018-2024
China Academy of Chinese Medical Sciences
2020-2024
Abstract Ferroptosis is a lipid peroxidation-driven and iron-dependent programmed cell death involved in multiple physical processes various diseases. Emerging evidence suggests that several pathogens manipulate ferroptosis for their pathogenicity dissemination, but the underlying molecular mechanisms remain elusive. Here, we identify protein tyrosine phosphatase A (PtpA), an effector secreted by tuberculosis (TB)-causing pathogen Mycobacterium (Mtb), triggers to promote Mtb dissemination....
Abstract Ubiquitin-mediated xenophagy, a type of selective autophagy, plays crucial roles in host defense against intracellular pathogens including Mycobacterium tuberculosis (Mtb). However, the exact mechanism by which ubiquitin targets invaded microbes to trigger xenophagy remains obscure. Here we show that could recognize Mtb surface protein Rv1468c, previously unidentified ubiquitin-binding containing eukaryotic-like ubiquitin-associated (UBA) domain. The UBA-mediated direct binding to,...
The eukaryotic-type protein kinase G (PknG), one of the eleven eukaryotic type serine-threonine (STPK) in Mycobacterium tuberculosis (Mtb), is involved mycobacterial survival within macrophages, presumably by suppressing phagosome and autophagosome maturation, which makes PknG an attractive drug target. However, exact mechanism inhibits pathogen clearance during infection remains largely unknown. Here, we show that promotes macroautophagy/autophagy induction but causing overall effect...
Mycobacterium tuberculosis PtpA is a secreted effector protein that dephosphorylates several proteins in the host cell cytoplasm, such as p-JNK, p-p38, and p-VPS33B, leading to suppression of innate immunity. Here we show that, addition, enters nucleus cells regulates expression genes, some which are known be involved immunity or proliferation migration (such GADD45A). can bind directly promoter region GADD45A vitro. Both phosphatase activity DNA-binding ability important suppressing immune...
Macrophage-mediated innate immune responses play crucial roles in host defense against pathogens. Recent years have seen an explosion of proteins that act as restriction factors blocking viral replication infected cells. However, the essential restricting Mycobacterium tuberculosis (Mtb) and their regulatory during mycobacterial infection remain largely unknown. We previously reported Mtb tyrosine phosphatase PtpA, a secreted effector protein required for intracellular survival Mtb, inhibits...
Abstract Chronic infections, including Mycobacterium tuberculosis (Mtb)-caused (TB), can induce host immune exhaustion. However, the key checkpoint molecules involved in this process and underlying regulatory mechanisms remain largely undefined, which impede application of checkpoint-based immunotherapy infectious diseases. Here, through adopting time-of-flight mass cytometry transcriptional profiling to systematically analyze natural killer (NK) cell surface receptors, we identify leukocyte...
The emergence and rapid spread of New Delhi Metallo-beta-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae strains has caused a great concern worldwide. To better understand the mechanisms underlying environmental adaptation those highly drug-resistant K. strains, we took advantage China's Shenzhou 10 spacecraft mission to conduct comparative genomic transcriptomic analysis NDM-1 strain (ATCC BAA-2146) being cultivated under different conditions. samples were recovered from semisolid...
During spaceflight, astronauts are subjected to various physical stressors including microgravity, which could cause immune dysfunction and thus potentially predispose infections illness. However, the mechanisms by microgravity affects innate immunity remain largely unclear. In this study, we conducted RNA-sequencing analysis show that simulated (SMG) suppresses production of inflammatory cytokines tumor necrosis factor (TNF) interleukin-6 (IL-6) as well activation signaling pathways p38...
Crosstalk between cell death programs confers appropriate host anti-infection immune responses, but how pathogens co-opt molecular switches of pathways to reprogram modalities for facilitating infection remains largely unexplored. Here, we identify mammalian entry 3C (Mce3C) as a pathogenic regulator secreted by Mycobacterium tuberculosis (Mtb), which causes featured with lung inflammation and necrosis. Mce3C binds cathepsin B (CTSB), noncaspase protease acting lysosome-derived determinant...
Infectious diseases, such as Mycobacterium tuberculosis (Mtb)-caused (TB), remain a global threat exacerbated by increasing drug resistance. Host-directed therapy (HDT) is promising strategy for infection treatment through targeting host immunity. However, the limited understanding of function and regulatory mechanism factors involved in immune defense against infections has impeded HDT development. Here, we identify ubiquitin ligase (E3) TRIM27 (tripartite motif-containing 27) protective...
The regulation of antiviral immunity is crucial in maintaining host immune homeostasis, a process that involves dynamic modulations organelles. Golgi apparatus increasingly perceived as organelle functioning critical platform for innate immunity, but the detailed mechanism by which it regulates remains elusive. Here, we identify Golgi-localized G protein-coupled receptor 108 (GPR108) regulator type Ι interferon responses targeting regulatory factor 3 (IRF3). Mechanistically, GPR108 enhances...
Aquaporins, integral membrane proteins widely distributed in organisms, facilitate the transport of water, glycerol, and other small uncharged solutes across cellular membranes play important physiological roles eukaryotes. However, characterizations functions prokaryotic aquaporins remain largely unknown. Here, we report that Streptococcus pneumoniae (pneumococcus) AqpC (Pn-AqpC), representing a new aquaporin subfamily possessing distinct substrate-selective channel, as an oxygen porin by...
Abstract Protein kinase G (PknG), a eukaryotic type serine-threonine protein (STPK) in Mycobacterium tuberculosis (Mtb), is secreted into the cytosol of infected macrophages to promote intracellular survival mycobacteria and has been considered as promising therapeutic target for (TB) treatment. However, molecular details Mtb PknG-host interactions remain obscure. Here, we demonstrate that PknG serves both ubiquitin-activating enzyme (E1) ubiquitin ligase (E3) ubiquitination degradation...