A5055535511- Autophagy in Disease and Therapy
- T-cell and B-cell Immunology
- Cell death mechanisms and regulation
- Bacterial biofilms and quorum sensing
- Reproductive System and Pregnancy
- Vibrio bacteria research studies
- interferon and immune responses
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
Czech Academy of Sciences, Institute of Microbiology
2025
Chinese Academy of Sciences
2022-2025
Institute of Microbiology
2022-2024
The inflammasome-mediated cleavage of gasdermin D (GSDMD) causes pyroptosis and inflammatory cytokine release to control pathogen infection, but how pathogens evade this immune response remains largely unexplored. Here we identify the known protein phosphatase PtpB from Mycobacterium tuberculosis as a phospholipid inhibiting host inflammasome-pyroptosis pathway. Mechanistically, dephosphorylated phosphatidylinositol-4-monophosphate phosphatidylinositol-(4,5)-bisphosphate in cell membrane,...
Abstract Chronic infections, including Mycobacterium tuberculosis (Mtb)-caused (TB), can induce host immune exhaustion. However, the key checkpoint molecules involved in this process and underlying regulatory mechanisms remain largely undefined, which impede application of checkpoint-based immunotherapy infectious diseases. Here, through adopting time-of-flight mass cytometry transcriptional profiling to systematically analyze natural killer (NK) cell surface receptors, we identify leukocyte...
Crosstalk between cell death programs confers appropriate host anti-infection immune responses, but how pathogens co-opt molecular switches of pathways to reprogram modalities for facilitating infection remains largely unexplored. Here, we identify mammalian entry 3C (Mce3C) as a pathogenic regulator secreted by Mycobacterium tuberculosis (Mtb), which causes featured with lung inflammation and necrosis. Mce3C binds cathepsin B (CTSB), noncaspase protease acting lysosome-derived determinant...