A5052843384- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- interferon and immune responses
- Tuberculosis Research and Epidemiology
Institute of Microbiology
2020-2024
Chinese Academy of Sciences
2020-2024
University of Chinese Academy of Sciences
2022-2024
China Academy of Chinese Medical Sciences
2024
The inflammasome-mediated cleavage of gasdermin D (GSDMD) causes pyroptosis and inflammatory cytokine release to control pathogen infection, but how pathogens evade this immune response remains largely unexplored. Here we identify the known protein phosphatase PtpB from Mycobacterium tuberculosis as a phospholipid inhibiting host inflammasome-pyroptosis pathway. Mechanistically, dephosphorylated phosphatidylinositol-4-monophosphate phosphatidylinositol-(4,5)-bisphosphate in cell membrane,...
Abstract Chronic infections, including Mycobacterium tuberculosis (Mtb)-caused (TB), can induce host immune exhaustion. However, the key checkpoint molecules involved in this process and underlying regulatory mechanisms remain largely undefined, which impede application of checkpoint-based immunotherapy infectious diseases. Here, through adopting time-of-flight mass cytometry transcriptional profiling to systematically analyze natural killer (NK) cell surface receptors, we identify leukocyte...
Abstract Previous reports have suggested a link between pulmonary tuberculosis (TB), which is caused by Mycobacterium (Mtb), and the development of lung adenocarcinoma (LUAD) sarcoidosis. Furthermore, these diseases share certain clinical similarities that can challenge differential diagnosis in some cases. Here, through comparison transcriptome-derived molecular signatures TB, LUAD sarcoidosis patients, we identify shared disease-related expression patterns. We also demonstrate MKI67 , an...