A5049122292- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- DNA Repair Mechanisms
- RNA modifications and cancer
Scripps MD Anderson Cancer Center
2024
The University of Texas MD Anderson Cancer Center
2023-2024
Abstract Mitochondria are hubs where bioenergetics, redox homeostasis, and anabolic metabolism pathways integrate through a tightly coordinated flux of metabolites. The contributions mitochondrial to tumor growth therapy resistance evident, but drugs targeting have repeatedly failed in the clinic. Our study pancreatic ductal adenocarcinoma (PDAC) finds that cellular lipid composition influence cancer cell sensitivity pharmacological inhibition electron transport chain complex I. Profiling...
Abstract It is unclear how cells counteract the potentially harmful effects of uncoordinated DNA replication in context oncogenic stress. Here, we identify WRAD (WDR5/RBBP5/ASH2L/DPY30) core as a modulator pancreatic ductal adenocarcinoma (PDAC) models. Molecular analyses demonstrated that interacts with replisome complex, disruption DPY30 resulting re-replication, damage, and chromosomal instability (CIN) without affecting cancer cell proliferation. Consequently, immunocompetent models,...
Abstract Mitochondria are hubs where bioenergetics, redox homeostasis, and anabolic metabolism pathways integrate through a tightly coordinated flux of metabolites. The essential contributions mitochondrial to fuel tumor growth resistance therapy now evident in multiple contexts. However, targeting the clinical setting has repeatedly failed, owing narrow therapeutic window remarkable ability cells activate compensatory metabolic programs. Thus, it is uncover additional mechanisms that may...