A5100651712- Metabolomics and Mass Spectrometry Studies
- Inflammatory Bowel Disease
- Microscopic Colitis
- Analytical Chemistry and Chromatography
- Advanced biosensing and bioanalysis techniques
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Molecular Biology Techniques and Applications
- Advanced Chemical Sensor Technologies
- Cancer, Hypoxia, and Metabolism
- Folate and B Vitamins Research
- Alcohol Consumption and Health Effects
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Intraocular Surgery and Lenses
- Nephrotoxicity and Medicinal Plants
- Biochemical effects in animals
- Traditional Chinese Medicine Analysis
- Biosensors and Analytical Detection
- Heavy Metals in Plants
- Neuroscience and Neuropharmacology Research
- Cancer, Lipids, and Metabolism
- Chromatography in Natural Products
- Colorectal Cancer Screening and Detection
- Nutritional Studies and Diet
Capital Medical University
2021-2025
Jiangxi Provincial Cancer Hospital
2024-2025
Beijing Tian Tan Hospital
2025
Harbin Medical University
2015-2024
Beijing Radiation Center
2017-2024
Tiangong University
2019-2024
South China University of Technology
2017-2024
Hebei University
2013-2024
Central South University
2020-2024
Guangdong Ocean University
2024
AIM:To study the prevalence and clinical biochemical, blood cell metabolic features of lean-non-alcoholic fatty liver disease (lean-NAFLD) its association with other diseases.METHODS: Demographic, biochemical examinations were conducted in all subjects this study.We classified into four groups according to their weight NAFLD status: lean-control, lean-NAFLD [body mass index (BMI) < 24 kg/m 2 ], overweight-obese control NAFLD.One-way analysis variance (ANOVA) was used compare means continuous...
Osteosarcoma is the most common malignant bone tumor in children and adolescence. Multiple immune-related genes have been reported different cancers. The aim to identify an gene signature for prospective evaluation of prognosis osteosarcoma patients. In this study, we evaluated infiltration immune cells 101 patients downloaded from TARGET using ssGSEA RNA-sequencing these patients, thus, high cell cluster, middle cluster low were generated. On foundation vs. normal osteosarcoma, found 108...
Abstract The emerging monkeypox virus (MPXV) has raised global health concern, thereby highlighting the need for rapid, sensitive, and easy-to-use diagnostics. Here, we develop a single-step CRISPR-based diagnostic platform, termed SCOPE (Streamlined CRISPR On Pod Evaluation platform), field-deployable ultrasensitive detection of MPXV in resource-limited settings. viral nucleic acids are rapidly released from rash fluid swab, oral saliva, urine samples 2 min via streamlined lysis protocol,...
There are few estimates of the incidence and prevalence inflammatory bowel disease in North American communities. We sought to estimate (IBD), including Crohn's (CD), ulcerative colitis (UC), among 3.2 million members Kaiser Permanente, Northern California, for period 1996-2002.All health plan who had one or more diagnoses CD (ICD-9 code 555) UC 556) on computerized records during 1996-2002 with at least 12 months membership were identified as possible IBD cases (N = 12,059). randomly...
To compare the incidence of cancer following tumor necrosis factor α (TNFα) inhibitor therapy to that with commonly used alternative therapies across multiple immune-mediated diseases.The Safety Assessment Biological Therapeutics study data from 4 sources: national Medicaid and Medicare databases, Tennessee Medicaid, pharmacy benefits plans for beneficiaries in New Jersey Pennsylvania, Kaiser Permanente Northern California. Propensity score-adjusted hazard ratios (HRs) 95% confidence...
Mangiferin has been shown to have the effect of improving dyslipidemia. Plasma free fatty acids (FFA) are closely associated with blood lipid metabolism as well many diseases including metabolic syndrome. This study is investigate whether mangiferin effects on FFA in hyperlipidemic rats. Wistar rats were fed a high-fat diet and administered simultaneously for 6 weeks. (50, 100, 150 mg/kg BW) decreased dose-dependently triglycerides (TG) levels plasma, their accumulations liver, but increased...
BACKGROUND AND AIMS Previous studies provide evidence that some immune-mediated diseases occur at greater frequency among inflammatory bowel disease (IBD) patients than in the general population. The present study examined co-occurrence of IBD with common disorders including asthma, psoriasis, type 1 diabetes, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, vitiligo, autoimmune thyroiditis (Grave's and Hashimoto's), chronic glomerulonephritis. METHODS We conducted a...
Alzheimer disease (AD) can be diagnosed by clinical and neuropsychologic tests at autopsy, but there are no simple effective diagnostic methods for detecting biomarkers in patients early stages of cognitive impairment. Early metabolic alterations that may facilitate AD diagnosis have not been thoroughly explored. We applied a nontargeted metabonomic approach using ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry to analyze serum urine samples from 46...
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic worldwide. Oxidative stress one main inducers NAFLD. Atractylodin (ART), a major active ingredient Atractylodes lancea, possesses potential antioxidant and anti-inflammatory activity in many types disease. In current study, underlying mechanism by which ART alleviates progression NAFLD was explored. The function facilitating investigated vitro vivo. Functionally, attenuated high-fat diet (HFD)-induced mice palmitic...
Enrichment and quantification of sugar phosphates (SPx) in biological samples were great significance medicine. In this work, a series zirconium-based metal-organic frameworks (MOFs) with different degrees defects, namely, HP-UiO-66-NH
There are few contemporary estimates of prevalence rates for inflammatory bowel disease (IBD) in diverse North American communities. We estimated the period IBD January 1, 1999, through June 30, 2001, among 1.8 million randomly sampled members nine integrated healthcare organizations US using computerized diagnoses and outpatient pharmaceutical dispensing. also assessed positive predictive value (PPV) sensitivities 1) case-finding algorithm, 2) 30-month sampling medical chart review linkage...
BACKGROUND Isolated postchallenge diabetes (IPD), a subtype of type 2 mellitus (T2DM) defined as 2-h postprandial plasma glucose ≥200 mg/dL (≥11.1 mmol/L) and fasting (FPG) &lt;108 (&lt;6.0 mmol/L), is often overlooked during screening for on the basis FPG concentrations. A key challenge early identification IPD by use serum, which critical large-scale screening. METHODS We applied nontargeted metabolomic approach using ultra-high-performance liquid chromatography–quadrupole TOF–mass...