A catalytic domino spirocyclization of 1,7-enynes with simple cycloalkanes and cyclo-1,3-dicarbonyls has been established via multiple C-C bond formations from alkynyl/alkenyl functions dual α,α-C(sp(3))-H abstraction/insertion. The reaction involves addition, 6-exo-dig cyclization radical coupling sequences under convenient conditions provides a concise access to spiro cyclopenta[c]quinolines in good excellent yields.

A new cascade three-component halosulfonylation of 1,7-enynes for efficient synthesis densely functionalized 3,4-dihydroquinolin-2(1H)-ones has been established from readily accessible arylsulfonyl hydrazides and NIS (or NBS). The reaction pathway involves in situ-generated sulfonyl radical-triggered α,β-conjugated addition/6-exo-dig cyclization/radical coupling sequence, resulting continuous multiple bond-forming events including C-S, C-C C-I C-Br) bonds to rapidly build up molecular complexity.

A metal-free synthesis of bifunctionalized indole derivatives was developed through a novel TBHP/TBAI-mediated oxidative coupling C2,C3-unsubstituted indoles with arylsulfonyl hydrazide. Under the same conditions C3-methyl substituted underwent diazotization process, affording 2-sulfonyldiazenyl-1H-indoles. The former reaction simultaneously established C–S and C–N bonds selective sulfonylation framework, enabling mild practical access to polyfunctionalized good excellent yields.

Alzheimer disease (AD) can be diagnosed by clinical and neuropsychologic tests at autopsy, but there are no simple effective diagnostic methods for detecting biomarkers in patients early stages of cognitive impairment. Early metabolic alterations that may facilitate AD diagnosis have not been thoroughly explored. We applied a nontargeted metabonomic approach using ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry to analyze serum urine samples from 46...

Abstract A new visible‐light photocatalytic arylsulfonylation and bicyclization of C( sp 3 )‐tethered 1,7‐enynes with sulfinic acids has been developed, delivering functionalized sulfone‐containing benzo[ a ]fluoren‐5‐ones generally good yields. This Eosin Y‐catalyzed approach makes use visible light as safe eco‐friendly energy source to drive cascade cyclization reactions, resulting in continuous multiple bond‐forming events including C–S C–C bonds efficiently construct polycyclic‐linked...

A new metal-free oxidative hydrophosphinylation of 1,7-enynes for forming polyfunctionalized 3,4-dihydroquinolin-2(1<italic>H</italic>)-ones has been realized using readily accessible diarylphosphine oxide and TBPB as an oxidant.

A visible light photocatalytic methylsulfonylation/bicyclization of C(sp³)-tethered 1,7-enynes has been established using a dimethyl sulfoxide (DMSO)/H₂O system as the methylsulfonyl source.

In this study, we present a novel catalyst-free energy transfer mediated radical rearrangement strategy for the aryl-heterofunctionalization of unactivated alkynes, leading to synthesis polyfunctional olefins with exceptional stereoselectivity. This innovative approach, driven by visible light, exemplifies green chemistry principles eliminating reliance on transition metals, external oxidants, and photocatalysts. The broad applicability our method is demonstrated through successful diverse...

Abstract A novel three‐component selenosulfonation of 1,7‐enynes with sulfinic acids and diphenyl diselenides for the formation multifunctional 3,4‐dihydroquinolin‐2(1 H )‐ones was developed in batch flow. This room‐temperature protocol provides a highly efficient approach to diverse selenosulfones moderate excellent yields broad scope substrates. It should provide potential synthesis method construction meaningful derivatives fields pharmaceutical biological chemistry. Additionally, an...

A new Cu(<sc>ii</sc>)-catalyzed formal [4 + 2] cycloaddition between quinone methides (QMs) including <italic>para</italic>-quinone (<italic>p</italic>-QMs) and <italic>ortho</italic>-quinone (<italic>o</italic>-QMs) electron-poor 3-vinylindoles was established.

A new catalytic difluorohydration of β-alkynyl ketones using NFSI as the fluorinating reagent has been established, diastereoselectively providing difluoride 1,5-dicarbonyl products, and some them were converted into difluorinated isoquinolines.

A new chelation-controlled hydrofuranization of unactivated olefins with α-alkynyl arylols is reported for the first time, and used to produce a wide range C₃-alkylated benzofurans generally good yields under mild conditions.

A new Pd(II)-catalyzed carbonyl-directing activation of alkenes has been established, enabling radical-induced selective fluorosulfonylation and aminosulfonylation carbonyl-tethered 1,7-enynes with sulfinic acids N-fluorobenzenesulfonimide (NFSI) under mild redox neutral conditions to access densely functionalized ( E)-3,4-dihydronaphthalen-1(2 H)-ones generally good yields high stereoselectivity. The selectivity these bifunctionalizations relies on the electronic nature substituents both...

As the worldwide elderly population has grown, incidence and prevalence of Alzheimer's disease (AD) steadily increased. The differential lifelong exposure populations to dietary fatty acids raised concerns about potential links bet

Photoinduced solvent-dependent cyclodimerizations of 1-alkynylnaphthalen-2-ols were developed for the first time, producing skeletally diverse bridged hexacyclic architectures with good yields and high stereoselectivities.

A photocatalytic strategy has been developed for the selective synthesis of ( E )-β-aminovinyl sulfones and )-β-amidovinyl through utilization allenamides sodium sulfinates.

Cholangiocarcinoma is an aggressive and heterogeneous malignancy originating from the bile duct epithelium. It associated with poor prognosis high mortality. The global incidence of cholangiocarcinoma rising, there urgent need for effective early diagnosis treatment strategies to reduce burden this devastating tumor. Small extracellular vesicles, including exosomes microparticles, are nanoscale vesicles formed by membranes that released both normally pathologically cells, mediating...

A new and expedient photocatalytic protocol for the construction of quinolin-2(1H)-ones via Markovnikov-type sulfonylation/6-endo-trig cyclization/selective C(O)-CF3 bond cleavage starting from N-alkyl-N-(2-ethynylphenyl)-2,2,2-trifluoroacetamides sulfinic acids has been developed. It is as an unprecedented preparation 4-sulfonylquinoline-2(1H)-ones with high efficiency, mild reaction conditions, acceptable yields a wide range substrates.

This study presents a convenient approach to the synthesis of indole- and benzofuran-based benzylic sulfones using unactivated alkynes containing aryl iodides sodium sulfinates under visible light irradiation. The procedure involves sequential series dehalogenation, carbo-cyclization, radical sulfonylation. Plausible insights into reaction mechanism are derived from control experiments, leading proposal cascade pathway.

An atom-economic method of preparing allylic sulfones via hydrosulfonylation allenes with sulfinic acids under Pd(0)-catalysis was reported. This process has a high degree regio- and stereoselectivity, provides the target product moderate to excellent yield. A wide range nitrogen- or oxygen-containing linear E-allylic have been synthesized. With support experimental research, possible mechanism proposed.

The asymmetric unit of the title compound, C(7)H(6)N(2)S, contains one half-mol-ecule; C and S atoms C=S group lie on a crystallographic mirror plane. In crystal structure, inter-molecular N-H⋯S hydrogen bonds link mol-ecules.