A5016173471- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Biochemical effects in animals
- Chromatography in Natural Products
- Epigenetics and DNA Methylation
- Machine Learning in Bioinformatics
- Cancer, Hypoxia, and Metabolism
- Fuzzy Logic and Control Systems
- Neural Networks and Applications
- Analytical Chemistry and Chromatography
- Cancer Immunotherapy and Biomarkers
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- Phosphodiesterase function and regulation
- Advanced Chemical Sensor Technologies
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- RNA modifications and cancer
- Natural product bioactivities and synthesis
- Polysaccharides and Plant Cell Walls
- Food Quality and Safety Studies
Zhejiang University
2024-2025
Ningbo University of Technology
2024-2025
Nanjing University of Chinese Medicine
2024
Krirk University
2024
Suzhou Traditional Chinese Medicine Hospital
2024
Baotou Medical College
2017-2023
Capital Medical University
2017-2022
Ocean University of China
2021-2022
Affiliated Hospital of Taishan Medical University
2021
Shandong First Medical University
2021
We aim at finding the smallest set of genes that can ensure highly accurate classification cancers from microarray data by using supervised machine learning algorithms. The significance minimum gene subsets is three-fold: 1) It greatly reduces computational burden and "noise" arising irrelevant genes. In examples studied in this paper, even allows for extraction simple diagnostic rules which lead to diagnosis without need any classifiers. 2) simplifies expression tests include only a very...
Abstract Septic cardiomyopathy is associated with mitochondrial damage and endoplasmic reticulum (ER) dysfunction. However, the upstream mediator of injury ER stress has not been identified thus little drug available to treat septic cardiomyopathy. Here, we explored role B‐cell receptor‐associated protein 31 (BAP31) in figure out whether melatonin could attenuate sepsis‐mediated myocardial depression via modulating BAP31. Lipopolysaccharide (LPS) was used establish model. Pathway analysis...
Alzheimer disease (AD) can be diagnosed by clinical and neuropsychologic tests at autopsy, but there are no simple effective diagnostic methods for detecting biomarkers in patients early stages of cognitive impairment. Early metabolic alterations that may facilitate AD diagnosis have not been thoroughly explored. We applied a nontargeted metabonomic approach using ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry to analyze serum urine samples from 46...
Diabetes is a risk factor for Alzheimer's disease (AD) in humans. Branched-chain amino acids (BCAAs, namely valine, leucine, and isoleucine) metabolic defect observed human diabetes, which associated with insulin resistance. But whether BCAAs connect diabetes AD remains unknown. Here, we show that BCAA may be one of the drivers AD. levels were increased blood patients mice or BCAA-enriched diet promoted development as evidenced by behavior pathological analysis. acid transaminase 1 2 (BCAT1...
Insulin degrading enzyme (IDE) is believed to act as a junction point of Type 2 diabetes (T2D) and Alzheimer's disease (AD); however, the underlying mechanism was not completely clear yet. Transgenic APPSwe/PS1 mice were used AD model treated with streptozocin/streptozotocin (STZ) develop mixed presenting both T2D. Morris Water Maze (MWM) recognition task performed trace cognitive function. The detection fasting plasma glucose (FPG) insulin concentration, oral tolerance test (OGTT)...
Ischemic tolerance in the brain can be induced by transient limb ischemia, and this phenomenon is termed remote ischemic preconditioning (RIPC). It still remains elusive how transfer of occurs. Exosomes cross blood-brain barrier, some molecules may neuroprotective signals from periphery to brain. Serum miRNA-126 associated with stroke, exosomal has shown protective effects against acute myocardial infarction. Therefore, study aims explore whether RIPC serum play a similar role. were isolated...
In this study, the influence of air-frying temperature on physical properties sturgeon steaks was explored. Meanwhile, comparison traditional deep fat frying (TF) and air fryer (AFF) methods quality, flavor, digestibility were investigated. The results indicated that along with increase (130, 160, 190℃) for 15 min, moisture content AFF steak surface decreased dramatically while interior well preserved. applied texture property analysis exhibited showed enhanced elasticity, low hardness, soft...
Type 2 diabetes (T2D) may play a relevant role in the development of Alzheimer's disease (AD), however, underlying mechanism was not clear yet. We developed an animal model presenting both AD and T2D, morris water maze (MWM) test recognition task were performed to trace cognitive function. Fasting plasma glucose (FPG) oral tolerance (OGTT) determined metabolism evolution. TUNEL assay apoptosis-related protein levels analyzed for detection neuronal apoptosis. Cyclic adenosine monophosphate...
Introduction: Rare-earth nanoparticles in the environment and human body pose a potential threat to health. Although toxic effects of rare-earth have been extensively studied, on early development are not well understood. In this study, we attempted explain neodymium oxide (Nd 2 O 3 ) development. Methods: We added Nd at different concentrations recorded mortality malformation rate per 24 hrs under microscope. The live embryos treated with were imaged as movies Z step lapses confocal...
Hypoxic preconditioning (HPC) as an endogenous mechanism can resist hypoxia/ischemia injury and exhibit protective effects on neurological function including learning memory. Although underlying molecular mechanisms remain unclear, HPC probably regulates the expression of molecules by modulating DNA methylation. Brain-derived neurotrophic factor (BDNF) activates its signaling upon binding to tropomyosin-related kinase B (TrkB) receptor, which is involved in neuronal growth, differentiation,...
Ankylosing spondylitis (AS) is a common chronic inflammatory rheumatic disease. Early and accurate detection essential for effective disease treatment. Recently, research has focused on genomics proteomics. However, the associated metabolic variations, especially fatty acid profiles, have been poorly discussed. In this study, gas chromatography-mass spectrometry (GC-MS) approach multivariate statistical analysis were used to investigate profiles of serum free acids (FFAs) esterified (EFAs)...
Epigenetic processes such as DNA methylation are essential for of gene expression in normal mammalian development. methyltransferases (DNMT) responsible initiating and maintaining methylation. It is known that 5-Aza-CdR, an inhibitor DNMT induces cytotoxicity by reducing activity various tumor cell lines. However, disturbances neuronal may also play a role altered brain functions. Thus, it was interest to determine whether alterations might be associated with functions using on mouse...
The role of phosphodiesterase 3 (PDE3), a cyclic AMP (cAMP)-degrading enzyme, in modulating gluconeogenesis remains unknown. Here, linderane, natural compound, was found to inhibit by activating hepatic PDE3 rat primary hepatocytes. underlying molecular mechanism and its effects on whole-body glucose lipid metabolism were investigated. effect linderane gluconeogenesis, cAMP content, phosphorylation cAMP-response element-binding protein (CREB) PDE activity examined cultured hepatocytes...
Cancer classification based on microarray gene expressions is an important problem. In this work, we use a t- test-based feature selection method to choose some genes from thousands of genes. After that, classify the data sets with fuzzy neural network (FNN) that proposed earlier. This FNN combines features initial model self-generation, parameter optimization, and rule-base simplification. We applied three well-known expression sets, i.e., lymphoma set (with 3 sub-types), small round blue...
Ketamine is a dissociative anesthetic agent that has been widely used in surgery and for relieving pain chronic cancer patients.We applied ketamine to breast cell line MDA-MB-231 detect the effect of treatment molecular mechanisms involved.We found can upregulate level anti-apoptosis protein Bcl-2, which promotes invasion proliferation.Knockdown Bcl-2 could inhibit increase reduce proliferation caused by human cells.Our findings provide new insight into effects treatment; we suggest...
Abstract Cerebral ischaemia is a common cerebrovascular disease and often induces neuronal apoptosis, leading to brain damage. Polygalasaponin F (PGSF) one of the components in Polygala japonica Houtt, it triterpenoid saponin monomer. This research focused on anti‐apoptotic effect PGSF during oxygen‐glucose deprivation reoxygenation (OGD/R) injury rat adrenal pheochromocytoma cells (PC12) primary cortical neurons. OGD/R treatment reduced viability PC12 was prevented by PGSF, as shown MTT...