A5101924640- Plant Molecular Biology Research
- Extracellular vesicles in disease
- Photosynthetic Processes and Mechanisms
- Cellular transport and secretion
- MicroRNA in disease regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Circular RNAs in diseases
- RNA modifications and cancer
- Plant Reproductive Biology
- Lipid metabolism and biosynthesis
- Algal biology and biofuel production
- Antimicrobial Peptides and Activities
- Neuroscience and Neuropharmacology Research
- Bacterial Genetics and Biotechnology
- Insect Resistance and Genetics
- Retinoids in leukemia and cellular processes
- Protein purification and stability
- Plant tissue culture and regeneration
- Protein Hydrolysis and Bioactive Peptides
- TGF-β signaling in diseases
- Barrier Structure and Function Studies
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Biochemical and Molecular Research
Hunan Agricultural University
2024
Nanjing Agricultural University
2019-2022
Sichuan Agricultural University
2022
Jiangsu Academy of Agricultural Sciences
2021-2022
Sichuan University
2022
Huazhong University of Science and Technology
2022
Bicêtre Hospital
2022
Tianjin First Center Hospital
2022
Tianjin Medical University
2022
Imperial College London
2022
Long non-coding RNAs (lncRNAs) have been reported to play essential roles in regulating the radiosensitivity of cancers. Prostate cancer-associated transcript 6 (PCAT6) exerts oncogenic several tumors. However, PCAT6 and its underlying mechanism triple-negative breast cancer (TNBC) not investigated.The expression levels PCAT6, microRNA-185-5p (miR-185-5p) tumor protein D52 (TPD52) were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Cell viability, apoptosis colony...
Ischemic tolerance in the brain can be induced by transient limb ischemia, and this phenomenon is termed remote ischemic preconditioning (RIPC). It still remains elusive how transfer of occurs. Exosomes cross blood-brain barrier, some molecules may neuroprotective signals from periphery to brain. Serum miRNA-126 associated with stroke, exosomal has shown protective effects against acute myocardial infarction. Therefore, study aims explore whether RIPC serum play a similar role. were isolated...
Epigenetic processes such as DNA methylation are essential for of gene expression in normal mammalian development. methyltransferases (DNMT) responsible initiating and maintaining methylation. It is known that 5-Aza-CdR, an inhibitor DNMT induces cytotoxicity by reducing activity various tumor cell lines. However, disturbances neuronal may also play a role altered brain functions. Thus, it was interest to determine whether alterations might be associated with functions using on mouse...
SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) complex formation is necessary for intracellular membrane fusion and thus has a key role in processes such as secretion. However, little known about the regulatory factors that bind to Qa-SNAREs, which are also syntaxins (SYPs) plants. Here, we characterized Arabidopsis (Arabidopsis thaliana) Tomosyn (AtTMS) demonstrated it conserved regulator of SYPs AtTMS binds strongly via its R-SNARE motif-containing C...
Oilseed-vegetable-dual-purpose (OVDP) rapeseed can effectively alleviate the land contradiction between crops and it supplements vegetable supplies in winter or spring. The soluble solids content (SSC) is an important index that used to evaluate quality sugar of fruits vegetables. However, genetic architecture underlying SSC Brassica napus shoots still unclear. Here, quantitative trait loci (QTLs) for B. were investigated by performing linkage mapping using a recombinant inbred line...
Abstract Skin thickness is closely related to the appearance of human skin, such as sagging and wrinkling, which primarily depends on level collagen I synthesized by dermal fibroblasts (DFs). Small extracellular vesicles (SEVs), especially those derived from DFs (HDFs), are crucial orchestrators in shaping physiological pathological development skin. However, limited supply skin prevents production a large amount HDFs-SEVs, pig used model In this study, SEVs Chenghua pigs (CH-SEVs),...
The correct folding of a protein is pre-requirement for its proper posttranslational modification. Escherichia coli Sec pathway, in which preproteins, an unfolded, translocation-competent state, are rapidly secreted across the cytoplasmic membrane, commonly assumed to be unfavorable their modification cytosol. Whether posttranslationally modified recombinant preproteins can efficiently transported via however, remains unclear. ACP and BCCP domain (BCCP87) carrier proteins that converted into...
As an important physiological and reproductive organ, the silique is a determining factor of seed yield breeding target trait in rapeseed (Brassica napus L.). Genetic studies silique-related traits are helpful for marker-assisted high-yield breeding. In this study, recombinant inbred population containing 189 lines was used to perform quantitative loci (QTLs) analysis five seven different environments. result, 120 consensus QTLs related were identified, including 23 length, 25 breadth, 29...
Rapeseed (Brassica napus L.) is mainly used for oil production and industrial purposes. A high photosynthetic efficiency the premise of a yield capable meeting people’s various demands. Chlorophyll-deficient mutants are ideal materials studying chlorophyll biosynthesis photosynthesis. In previous study, we obtained mutant yl1 leaf yellowing throughout growth period by ethyl methanesulfonate mutagenesis B. napus. genetic analysis showed that chlorophyll-deficient phenotype was controlled one...
The fall armyworm Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) is a notorious invasive pest wreaking havoc on various crops globally. Nucleopolyhedroviruses (NPVs) are viral pathogens that specially target lepidopteran pests. However, the homologous virus, multiple nucleopolyhedrovirus (SfMNPV), has not been commercialized in China. Therefore, understanding molecular mechanisms underlying heterologous virus-host interactions can inform design of virus-based insecticides for...
Purpose: Recent studies have shown that transforming growth factor β (TGFβ) signaling participates in the epileptogenesis. Serine-threonine kinase receptor-associated protein (STRAP) and Smad7 synergize inhibition of TGFβ signaling. The aim present study was to determine expression pattern STRAP hippocampus temporal lobe cortex pilocarpine-induced rats models epilepsy. Methods: Lithium chloride-pilocarpine-induced with status epilepticus (SE) were established. Total 60 male Sprague-Dawley...
Investigation of parthenocarpy, the production fruit without fertilization, in multiple plant species could result development technologies for conferring seedless fruits and increased stability formation economically important plants. We studied parthenocarpy model Nicotiana tabacum L., observed variability expression trait among diverse genetic materials. Parthenocarpy was found to be partially dominant, a single major quantitative locus on linkage group 22 control doubled haploid mapping...
Chloroplast development is crucial for photosynthesis and plant growth many factors are involved in its regulation. The regulatory mechanism differs different green tissues, previous studies have focused on chloroplasts leaves. In this study, a mutant with sepal-specific chlorophyll-deficiency was observed Brassica napus named as df74. Genetic analysis indicated that the phenotype controlled by single recessive nuclear gene. gene located chromosome C08 bulked-segregant whole-genome...
Abstract Gliosis is an important feature of temporal lobe epilepsy (TLE), but the regulatory mechanism glial cell activation remains unclear. Small nucleolar RNA host gene 3 (Snhg3) has been reported to be involved in proliferation and migration various cancers. However, its role development TLE hardly explored. Here, we established a mouse model by injecting intraperitoneally with pilocarpine, found that Tweak expression was significantly induced mice. Inhibiting injection siRNA notably...