A5102766990- RNA Interference and Gene Delivery
- Advanced Polymer Synthesis and Characterization
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Hydrogels: synthesis, properties, applications
- Dendrimers and Hyperbranched Polymers
- Nanoparticle-Based Drug Delivery
- Polymer Surface Interaction Studies
- biodegradable polymer synthesis and properties
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Click Chemistry and Applications
- Microbial Natural Products and Biosynthesis
- Silk-based biomaterials and applications
- Genomics and Phylogenetic Studies
- Constructed Wetlands for Wastewater Treatment
- Photopolymerization techniques and applications
- Plant nutrient uptake and metabolism
- 3D Printing in Biomedical Research
- Food Quality and Safety Studies
- Aquaculture Nutrition and Growth
- Microbial Community Ecology and Physiology
- Immunotherapy and Immune Responses
- Plant Stress Responses and Tolerance
- Aquaculture disease management and microbiota
Ludong University
2025
Harvard University
2019-2024
The University of Texas at Dallas
2023-2024
Hong Kong University of Science and Technology
2005-2024
University of Hong Kong
2005-2024
Shandong First Medical University
2018-2024
Shandong Tumor Hospital
2018-2024
Jilin Agricultural University
2019-2022
University College Dublin
2014-2020
Baotou Medical College
2020
Stem cells have shown substantial promise for various diseases in preclinical and clinical trials. However, low cell engraftment rates significantly limit the translation of stem therapeutics. Numerous injectable hydrogels been developed to enhance retention. Yet, design an ideal material with tunable properties that can mimic different tissue niches regulate behaviors remains unfulfilled promise. Here, poly(ethylene glycol) (PEG)–gelatin hydrogel is designed highly properties, from a...
Highly branched poly(β-amino ester) polymers are developed to carry a gene and enter cells for the production of protein.
Most high-yielding rice cultivars developed for irrigated conditions, including the widely grown lowland variety IR64, are highly susceptible to drought stress. This limits their adoption in rainfed environments where there is a risk of water shortage during growing season. Mapping studies using lowland-by-upland populations have provided limited information about genetic basis variation yield under drought. One approach simultaneously improve and understand tolerance generate backcross...
1A series of hyperbranched poly(β-amino ester) polymers have been synthesized <italic>via</italic> a Michael addition approach for the fabrication hydrogels wound healing.
Drug nanoparticles hitchhike on erythrocytes to target chemotherapy the lungs for treating metastasis.
Current therapies for most neurodegenerative disorders are only symptomatic in nature and do not change the course of disease. Gene therapy plays an important role disease modifying therapeutic strategies. Herein, we have designed optimized a series highly branched poly(β-amino ester)s (HPAEs) containing biodegradable disulfide units HPAE backbone (HPAESS) guanidine moieties (HPAESG) at extremities. The polymers used to deliver minicircle DNA multipotent adipose derived stem cells (ADSCs)...
Significance Red blood cells perform the unique function of capturing certain pathogens in and presenting them to immune spleen. We developed a strategy based on this innate red deliver vaccine nanoparticles This biomimetic induced strong vaccination response without need for foreign adjuvants.
The study describes a synthetic hemostatic agent that can be intravenously injected to reduce internal hemorrhage.
Highly branched poly(β-amino esters) (HPAEs) are developed via a facile and controllable "A2+B3/B2" strategy successfully. As nonviral gene delivery vectors, the performance of HPAEs is superior to well-studied linear counterpart as well leading commercial reagent Superfect. When combined with minicircle DNA construct, can achieve ultrahigh transfection efficiency, especially in keratinocytes.
Abstract Proteins are among the most common therapeutics for treatment of diabetes, autoimmune diseases, cancer, and metabolic others. Despite their use, current protein therapies, which injectables, have several limitations. Large proteins such as monoclonal antibodies (mAbs) suffer from poor absorption after subcutaneous injections, thus forcing administration by intravenous injections. Even small insulin slow pharmacokinetics poses limitations in effective management diabetes. Here, a...
The choroid plexus (ChP) of the brain plays a central role in orchestrating recruitment peripheral leukocytes into nervous system (CNS) through blood-cerebrospinal fluid (BCSF) barrier pathological conditions, thus offering unique niche to diagnose CNS disorders. We explored whether magnetic resonance imaging ChP could be optimized for mild traumatic injury (mTBI). mTBI induces subtle, yet influential, changes and is currently severely underdiagnosed. hypothesized that sufficient alterations...
Red soils, which are widely distributed in tropical and subtropical regions of southern China, characterized by low organic carbon, high content iron oxides, acidity and, hence, likely to be ideal habitats for acidophilic actinomycetes. However, the diversity biosynthetic potential actinomycetes such underexplored. Here, a total 600 actinomycete strains were isolated from red soils collected Jiangxi Province southeast China. 16S rRNA gene sequence analysis revealed isolates, into 26 genera,...
A successful polymeric gene delivery vector is denoted by both transfection efficiency and biocompatibility. However, the existing vectors with combined high efficacy minimal toxicity still fall short. The most widely used polyethylene imine (PEI), polyamidoamine (PAMAM) poly(dimethylaminoethyl methacrylate) (PDMAEMA) suffer from correlation: either too toxic or little effective. Here, we demonstrate that highly branched poly(β-amino esters) (HPAEs), a type of recently developed vector, low...
Highly branched poly(β-amino ester)s were synthesised for safer and more efficient gene delivery to human keratinocytes than commercial transfection reagents.
Abstract The mucus barrier lining the gastrointestinal tract poses a significant to oral delivery of macromolecular drugs. Successful approaches overcoming this have primarily focused on reducing drug and carrier interactions with or disrupting layer directly. Choline‐based ionic liquids (ILs) such as choline geranate glycolate (CGLY) recently been shown be effective in enhancing intestinal absorption macromolecules insulin immunoglobulin (IgG), respectively. Herein, use choline‐based ILs...