A5081387529- Electrochemical Analysis and Applications
- Ionic liquids properties and applications
- Advanced Drug Delivery Systems
- Electrochemical sensors and biosensors
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Analytical Chemistry and Sensors
- Electrocatalysts for Energy Conversion
- Surfactants and Colloidal Systems
- Innovative Microfluidic and Catalytic Techniques Innovation
- Graphene and Nanomaterials Applications
- Conducting polymers and applications
- Lipid Membrane Structure and Behavior
- Advanced Nanomaterials in Catalysis
- Essential Oils and Antimicrobial Activity
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Reactions
- Mesoporous Materials and Catalysis
- Mosquito-borne diseases and control
- Molecular Junctions and Nanostructures
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Analytical Chemistry and Chromatography
- HIV Research and Treatment
University of Mississippi
2021-2024
Harvard University
2017-2022
Los Angeles Pierce College
2020
University of Oxford
2014-2018
Oxfam
2016-2018
Science Oxford
2017-2018
The University of Sydney
2015
UNSW Sydney
2013
Ionic liquids (ILs) and deep eutectic solvents have shown great promise in drug delivery applications. Choline-based ILs, particular choline geranic acid (CAGE), been used to enhance the transdermal of several small large molecules. However, detailed studies outlining design principles ILs for are still lacking. Using two model drugs differing hydrophilicities, acarbose ruxolitinib 16 dependence skin penetration on chemical properties is examined. First, impact ion stoichiometry assessed...
The continued emergence of antibiotic-resistant organisms has severely depleted our arsenal effective antimicrobials. Ionic liquids (ILs) show great promise as antibacterial agents but understanding the mechanism attack on bacterial cells is key to ensuring that design IL-based biocides impart maximum efficacy with minimal toxicity, while also avoiding potential for target become resistant. Here we report attributes a set choline and geranate (CAGE)-based ILs identify by which they interact...
Ultratrace levels of Hg2+ have been quantified by undertaking linear sweep voltammetry with a silver nanoparticle-modified glassy carbon electrode (AgNP-GCE) in aqueous solutions containing Hg2+. This is achieved monitoring the change stripping peak concentration resulting from galvanic displacement mercury: Ag(np) + 1/2Hg2+(aq) → Ag+(aq) 1/2Hg(l). facile and reproducible detection method exhibits an excellent dynamic range 100.0 pM to 10.0 nM R2 = 0.982. The limit (LoD) based on 3σ 28 Hg2+,...
The electroreduction of carbon dioxide is systematically investigated in room-temperature ionic liquids (RTILs) to establish the effect electrode material, cation, and anion on mechanism reduction. Silver, gold, platinum, glassy macroelectrodes are using cyclic voltammetry 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([Bmim][NTf2]). On silver electrodes, a diffusion-limited reductive peak current observed, while for density 6 times smaller. No appreciable reduction...
Abstract Transdermal delivery offers a patient‐friendly method of drug administration. An ideal formulation for transdermal should have high potency to enhance skin permeation and low tendency induce irritation. Ionic liquids (ILs) deep eutectic solvents (DESs) recently been proposed serve as an excellent platform enable various therapeutics including proteins siRNA. In spite their success, general safety‐efficacy behavior ILs/DESs is not reported. Using safety efficacy two design criteria,...
An ionic liquid formulation ablates tumors, uniformly distributes drugs in the ablation zone, and has synergistic effects with chemotherapy.
Abstract The mucus barrier lining the gastrointestinal tract poses a significant to oral delivery of macromolecular drugs. Successful approaches overcoming this have primarily focused on reducing drug and carrier interactions with or disrupting layer directly. Choline‐based ionic liquids (ILs) such as choline geranate glycolate (CGLY) recently been shown be effective in enhancing intestinal absorption macromolecules insulin immunoglobulin (IgG), respectively. Herein, use choline‐based ILs...
Abstract Delivering cargo to the central nervous system (CNS) remains a pharmacological challenge. For infectious diseases such as HIV, CNS acts latent reservoir that is inadequately managed by systemic antiretrovirals (ARTs). ARTs thus cannot eradicate and given infection, patients experience neurological deficits collectively referred “neuroHIV”. Herein, development of bioinspired ionic liquid‐coated nanoparticles (IL‐NPs) for in situ hitchhiking on red blood cells (RBCs) reported, which...
Herein, we focus on the design, synthesis, and characterization of thienothiadiazole (TTD)-based near-infrared II (NIR-II) theranostic fluorophores their nanoparticles.
Choline and geranic acid (CAGE)-based ionic liquids have been recently developed for applications in drug delivery. Understanding the microscopic structures of CAGE presence water is critical its continued use biomedical as it will undoubtedly come into contact with physiological fluids. Water can drastically impact physicochemical properties liquids, including CAGE. Computational experimental characterization, namely viscosity, conductivity, self-diffusion coefficient, were employed here to...
Abstract This Perspective critically evaluates the ways in which electrode surface modification affects effectiveness of electroanalytical techniques. The use various voltammetric techniques, role increasing selectivity, manipulation electron transfer kinetics, as well impact increased area are discussed. It is critical that motivations and physical implications altering properly understood before intricate, impractical modifications employed do not significantly improve performance sensor.
Ionic liquid–modified nanoparticles show extended circulation and redirected biodistribution in mice compared to control particles.
More than 70% of American adults are overweight or obese, a precondition leading to chronic diseases, including diabetes and hypertension. Among other factors, diets with high fat carbohydrate content have been implicated in obesity. In this study, we hypothesize that the choline geranate (CAGE) ionic liquid can reduce body weight by decreasing absorption through intestine. vitro studies performed using docosahexaenoic acid (DHA), model molecule, show CAGE forms particles 2 4 μm diameter...
Linear-dendritic block copolymers (LDBCs) have emerged as promising materials for drug delivery applications, with their hybrid structure exploiting advantageous properties of both linear and dendritic polymers. LDBCs encapsulation efficiencies that can be used to encapsulate hydrophobic hydrophilic dyes bioimaging, cancer therapeutics, small biomolecules. Additionally, LDBCS readily functionalized varying terminal groups more efficient targeted delivery. However, depending on structural...
The effect of a range ionic liquids, with systematic variations in the cation and anion, on rate constant an aromatic substitution process was investigated. Temperature-dependent kinetic data allowed calculation activation parameters for each solvent. These demonstrate generalised liquid effect, increase observed solvent, though microscopic origins enhancement differ nature liquid.
The rate of reaction a Menschutkin process in range ionic liquids with different cations was investigated, temperature-dependent kinetic data giving access to activation parameters for the each solvent. These data, along molecular dynamics simulations, demonstrate importance accessibility charged centre on cation and that key interactions are generalised electrostatic nature.