A5075501025- Nanoparticle-Based Drug Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV Research and Treatment
- Mosquito-borne diseases and control
- Electrochemical sensors and biosensors
- Advanced Drug Delivery Systems
- Lipid Membrane Structure and Behavior
- Graphene and Nanomaterials Applications
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Curcumin's Biomedical Applications
- Analytical Chemistry and Chromatography
- Ionic liquids properties and applications
University of Mississippi
2022-2024
Abstract Delivering cargo to the central nervous system (CNS) remains a pharmacological challenge. For infectious diseases such as HIV, CNS acts latent reservoir that is inadequately managed by systemic antiretrovirals (ARTs). ARTs thus cannot eradicate and given infection, patients experience neurological deficits collectively referred “neuroHIV”. Herein, development of bioinspired ionic liquid‐coated nanoparticles (IL‐NPs) for in situ hitchhiking on red blood cells (RBCs) reported, which...
Macrophages play a diverse, key role in many pathologies, including inflammatory diseases, cardiovascular and cancer. However, therapeutic strategies targeting macrophages suffer from systemic off-target toxicity resulting notoriously narrow windows. To address this shortcoming, the development of poly(propylene sulfide)-b-poly(methacrylamidoglucopyranose) [PPS-b-PMAG] diblock copolymer-based nanoparticles (PMAG NPs) capable releasing drug presence reactive oxygen species (ROS) is reported....
Delivering cargo to the central nervous system (CNS) remains a pharmacological challenge. For infectious diseases such as HIV, CNS acts latent reservoir that is inadequately managed by systemic antiretrovirals (ARTs). ARTs thus cannot eradicate and given infection, patients experience an array of neurological deficits are collectively referred 'neuroHIV'. Herein we report development bioinspired ionic liquid-coated nanoparticles (IL-NPs) for
Abstract Less than 5% of intravenously-injected nanoparticles (NPs) reach destined sites in the body due to opsonization and immune-based clearance vascular circulation. By hitchhiking situ onto specific blood components post-injection, NPs can selectively target tissue for unprecedentedly high drug delivery rates . Choline carboxylate ionic liquids (ILs) are biocompatible liquid salts <100℃ composed bulky asymmetric cations anions. This class ILs has been previously shown significantly...