A5048948562- Dendrimers and Hyperbranched Polymers
- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Surfactants and Colloidal Systems
- Ionic liquids properties and applications
- Mesoporous Materials and Catalysis
- Organic Light-Emitting Diodes Research
- biodegradable polymer synthesis and properties
- Garlic and Onion Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Cancer therapeutics and mechanisms
- Perovskite Materials and Applications
- Plant chemical constituents analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Genomics, phytochemicals, and oxidative stress
- Synthesis and Reactivity of Heterocycles
- Synthesis and properties of polymers
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- Conducting polymers and applications
University of Mississippi
2019-2024
Linear-dendritic block copolymers (LDBCs) have emerged as promising materials for drug delivery applications, with their hybrid structure exploiting advantageous properties of both linear and dendritic polymers. LDBCs encapsulation efficiencies that can be used to encapsulate hydrophobic hydrophilic dyes bioimaging, cancer therapeutics, small biomolecules. Additionally, LDBCS readily functionalized varying terminal groups more efficient targeted delivery. However, depending on structural...
This study represents a successful approach toward employing polycaprolactone-polyamidoamine (PCL-PAMAM) linear dendritic block copolymer (LDBC) nanoparticles as small-molecule carriers in NIR imaging and photothermal therapy. A feasible robust synthetic strategy was used to synthesize library of amphiphilic LDBCs with well-controlled hydrophobic-to-hydrophilic weight ratios. Systems hydrophobic ratio higher than 70% formed aqueous media, which show hydrodynamic diameters 51.6 96.4 nm. These...
Shortwave infrared (SWIR)-emitting small molecules are desirable for biological imaging applications. In this study, four novel pentamethine indolizine cyanine dyes were synthesized with N,N-dimethylaniline-based substituents on the periphery at varied substitution sites. The studied via computational chemistry and optical spectroscopy both in solution when encapsulated. Dramatic spectral shifts absorption emission spectrum wavelengths added donor groups observed. Significant an emissive...
This study represents a comparative analysis of the solution behavior and self-assembly pattern two linear dendritic block copolymers (LDBCs) composed generation 3 polyamidoamine (PAMAM) dendron as poly(caprolactone) (PCL) block, latter which is modified with pendant phenyl groups. Phenyl substituents were introduced to induce physical cross-linking in LDBC nanoparticles via π–π stacking. A synthetic strategy was developed access substituted LDBCs through an ε-caprolactone monomer derivative...
ABSTRACT Herein, we present a facile and comprehensive synthetic methodology for the preparation of polyester‐polyamidoamine (PAMAM) (i.e., polyester: polylactide [PLA] (hydrophobic) polyamidoamine, PAMAM [hydrophilic]) polymers. A library PLA‐PAMAM linear dendritic block copolymers (LDBCs) in which both l d , were employed mass ratios 30:70, 50:50, 70:30, 90:10 (PLA:PAMAM) synthesized analyzed. When placed aqueous media, immiscibility hydrophilic hydrophobic segments leads to...
Abstract This study summarizes the synthesis, characterization, and evaluation of a library biocompatible self‐assembling Janus dendrimers (JDs) their resulting nanostructures possessing either cationic (NH 3 + ), anionic (COO − or neutral (OH) surface. Strategically designed for applications in therapeutic delivery, are comprised polyamidoamine (PAMAM) dendron as hydrophilic portion fatty acid (FA) functionalized dendrons hydrophobic portion. The physicochemical characterization vitro cell...
The challenges faced with current fluorescence imaging agents have motivated us to study two nanostructures based on a hydrophobic dye, 6 H -pyrrolo[3,2- b :4,5- ’]bis [1,4]benzothiazine (TRPZ). TRPZ is heteroacene rigid, pi-conjugated structure, multiple reactive sites, and unique spectroscopic properties. Here we coupled tert-butyl carbamate (BOC) protected 2,2-bis(hydroxymethyl)propanoic acid (bisMPA) dendron via azide-alkyne Huisgen cycloaddition. Deprotection of the amine groups...
Abstract As the field of theranostics expands, an imminent need arises for multifaceted polymer‐based nanotechnologies clinical application. In this work, reversible addition‐fragmentation chain transfer (RAFT) aqueous emulsion polymerization is used to form 19 F‐containing amphiphilic hybrid block copolymers (HBCs). Employing a cationic dendritic macromolecular agent (mCTA), polymer frameworks comprised chemically distinctive blocks differing architectures (i.e., and grafted/linear) are...
Abstract Ionic liquids (ILs) have emerged as promising biomaterials for enhancing drug delivery by functionalizing polymeric nanoparticles (NPs). Despite the biocompatibility and biofunctionalization they confer upon NPs, little is understood regarding degree in which non‐covalent interactions, particularly hydrogen bonding electrostatic govern IL‐NP supramolecular assembly. Herein, we use salt (0‐1 M sodium sulfate) acid (0.25 hydrochloric at pH 4.8) titrations to disrupt IL‐functionalized...