A5101439997- Cancer Treatment and Pharmacology
- Osteoarthritis Treatment and Mechanisms
- Extracellular vesicles in disease
- Synthetic Organic Chemistry Methods
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Microbial Natural Products and Biosynthesis
- Nanoplatforms for cancer theranostics
- Anesthesia and Neurotoxicity Research
- Indoor Air Quality and Microbial Exposure
- Corneal surgery and disorders
- Bone and Joint Diseases
- Corneal Surgery and Treatments
- Genomics, phytochemicals, and oxidative stress
- Glaucoma and retinal disorders
- Geochemistry and Elemental Analysis
- Silk-based biomaterials and applications
- Nanoparticle-Based Drug Delivery
- Skin Protection and Aging
- Inflammatory Biomarkers in Disease Prognosis
- Microtubule and mitosis dynamics
- Knee injuries and reconstruction techniques
- 14-3-3 protein interactions
- Nanoparticles: synthesis and applications
- Acute Ischemic Stroke Management
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Tianjin Huanhu Hospital
2023
Anhui Provincial Hospital
2023
Peking Union Medical College Hospital
2022-2023
Xuan Wu Hospital of the Capital Medical University
2021
Baotou Medical College
2020
Shandong Provincial Hospital
2017
Jinan Central Hospital
2017
Shandong University
2017
University of Pittsburgh
2010-2011
The dictyostatins are a promising class of potential anti-cancer drugs because they powerful microtubule-stabilizing agents, but the complexity their chemical structures is severe impediment to further development. On basis both synthetic and medicinal chemistry analyses, 16-desmethyl-25,26-dihydrodictyostatin its C6 epimer were chosen as potentially potent yet accessible dictyostatin analogues, three new syntheses developed. A relatively classical synthesis involving vinyllithium addition...
Introduction: Rare-earth nanoparticles in the environment and human body pose a potential threat to health. Although toxic effects of rare-earth have been extensively studied, on early development are not well understood. In this study, we attempted explain neodymium oxide (Nd 2 O 3 ) development. Methods: We added Nd at different concentrations recorded mortality malformation rate per 24 hrs under microscope. The live embryos treated with were imaged as movies Z step lapses confocal...
The natural product (--)-dictyostatin is a microtubule-stabilizing agent that potently inhibits the growth of human cancer cells, including paclitaxel-resistant clones. Extensive structure-activity relationship studies have revealed several regions molecule can be altered without loss activity. most potent synthetic dictyostatin analogue described to date, 6-epi-dictyostatin, has superior in vivo antitumor activity against breast xenografts compared with paclitaxel. In spite their...
The dictyostatins are powerful microtubule-stabilizing agents that have shown antiproliferative activity against a variety of human cancer cell lines. Two highly active analogs dictyostatin, 25,26-dihydrodictyostatin and 25,26-dihydro-6-epi-dictyostatin, were prepared by new streamlined total synthesis route. Three complete carbon fragments to achieve maximum convergency. These coupled Horner-Wadsworth-Emmons reaction sequence an esterification. A late stage Nozaki-Hiyama-Kishi was then used...
Abstract Background Hypoxia-mediated radioresistance is the main obstacle to successful treatment of glioblastoma (GBM). Enhancing hypoxic radiosensitivity and alleviating tumor hypoxia are both effective means improve therapeutic efficacy, combination two highly desirable meaningful. Results Herein, we construct a low-dose pleiotropic radiosensitive nanoformulation consisting high-Z atomic nanocrystal core mesoporous silica shell, surface-modified with angiopep-2 (ANG) peptide loaded nitric...
Acute photodamage is an acute inflammatory reaction of the skin after ultraviolet (UV) irradiation. Many drugs have been successfully used for treatment and prevention photodamage.To evaluate molecular mechanism N-terminal 5-mer peptide analog P165 amyloid precursor protein in repairing photodamaged rat skin.We establish a model UVB photodamage. The ratskin was treated with or without 250, 500, and, 1000 μM P165. Histological analysis performed by hematoxylin eosin staining. Apoptotic cells...
Background. This study is aimed at investigating the relationship between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), and hyperhomocysteinemia (HHCY) in patients with ischemic stroke (IS). Methods. retrospectively analyzed clinical data laboratory results of 110 IS patients. According to cut-off value <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mtext>HCY</mtext> <mo>=</mo> <mn>15</mn> <mtext> </mtext> <mi>μ</mi> <mtext>mol</mtext> <mo>/</mo>...
Objective To evaluate the safety and efficacy of epithelium-off corneal collagen cross-linking (CXL) induced by riboflavin ultraviolet A light for keratoconus in teenagers. Methods The medical records consecutive patients (30 eyes 19 cases) at age 14-18 years treated with CXL were analyzed this retrospective self-control study. Data from preperative 3-, 6-, 12-month postoperative examinations one way repeated ANOVA. The clinical evaluations included uncorrected visual acuity (UCVA),...