A5101774472- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Plant Micronutrient Interactions and Effects
- Pneumonia and Respiratory Infections
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Polymer Surface Interaction Studies
- Gut microbiota and health
- Phytase and its Applications
- Bacterial biofilms and quorum sensing
- Advanced Breast Cancer Therapies
- Wind and Air Flow Studies
- Diagnosis and treatment of tuberculosis
- Antibiotic Resistance in Bacteria
- Fluid Dynamics and Vibration Analysis
- Membrane Separation Technologies
- Aerodynamics and Fluid Dynamics Research
- Microbial Inactivation Methods
- Winter Sports Injuries and Performance
- Cancer Treatment and Pharmacology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- Bacterial Infections and Vaccines
- Water Systems and Optimization
- Clostridium difficile and Clostridium perfringens research
First People's Hospital of Chongqing
2025
Chongqing University
2025
Hangzhou Medical College
2014-2024
Xihua University
2012-2023
Hanyang University
2022
Fudan University Shanghai Cancer Center
2021
Shanghai Medical College of Fudan University
2021
The First People's Hospital of Changzhou
2017
Southwest University
2011-2013
Johns Hopkins University
2013
Trans-translation mediated by SsrA (tmRNA) and its associated protein SmpB plays an important role in rescuing stalled ribosomes detoxifying toxic products under stress conditions. However, the of bacterial persister survival has not been studied. The recent finding that pyrazinamide as a unique drug inhibits trans-translation Mycobacterium tuberculosis prompted us to examine survival. Using Escherichia coli model, we constructed mutants assessed susceptibility various antibiotics conditions...
Abstract Background Liver metastasis is a significant adverse predictor of overall survival (OS) among breast cancer patients. The purpose this study was to determine the risk and prognostic factors with liver metastases (BCLM). Methods Data on 311,573 patients from Surveillance, Epidemiology, End Results (SEER) database 1728 BCLM Fudan University Shanghai Cancer Center (FUSCC) were included. Logistic regression used identify for metastasis. Cox proportional hazards model adopted independent...
Insulin degrading enzyme (IDE) is believed to act as a junction point of Type 2 diabetes (T2D) and Alzheimer's disease (AD); however, the underlying mechanism was not completely clear yet. Transgenic APPSwe/PS1 mice were used AD model treated with streptozocin/streptozotocin (STZ) develop mixed presenting both T2D. Morris Water Maze (MWM) recognition task performed trace cognitive function. The detection fasting plasma glucose (FPG) insulin concentration, oral tolerance test (OGTT)...
Human papillomavirus (HPV) infection is the main etiological factor for cervical cancer and premalignant lesions of cervix. The purposes present study were to determine prevalence type-specific HPV infections association different types with dysplasia among women in Zhejiang province, Southeast China. A total 15,267 presenting a gynaecological outpatient clinic enrolled this study. Women screened addition routine cytology testing. Microarray hybridization liquid-based tests used detect...
The flow characteristics of the draft tube a Francis turbine have significant influence on stability. Numerical simulations were performed for under three different output conditions 20%, 100%, and 120% at rated maximum heads. Laser Doppler velocimetry (LDV) tests conducted to test model. in tube, mechanism change, effect opening vortex rope analyzed. results showed that large invisible conical cross-section inlet gradually changed tangible as guide vane (GVO) increased. pressure velocity...
Mycobacterium tuberculosis (MTB) remains one of the most significant human pathogens since its discovery in 1882.An estimated 1.5 million people died from tubercle bacillus (TB) 2006, and globally, there were an 9.27 incident cases TB 2007.Glyoxylate bypass pathway occurs a wide range plays key role pathogenesis tuberculosis.Isocitrate lyase (ICL) can catalyses first step this pathway, reversibly cleaves isocitrate into succinate glyoxylate.So, ICL may represent good drug target for...
As an effective drag reduction control method, porous media have attracted extensive attention in various engineering fields. In this paper, the large eddy simulation method is used to study flow problem around a cylinder with and without covering at subcritical Reynolds numbers. The characteristics mechanism of covered were studied. results aerodynamic coefficient show that when number 5.6 × 104 are arranged on leeward side azimuth angle 270°, rate largest, reaching 8.53%. field indicate...
Haemophilus influenzae (H. influenzae) is one of the most important pathogenic bacteria causing respiratory tract infection diseases in children. There are two main types H. influenzae, encapsulated and nontypeable (NTHi). Serotype b (Hib) used to be epidemic type invasive infection. However, epidemiology disease has changed substantially, now caused by NTHi other serotypes influenzae. The aim this study was determine strains Zhejiang Province China, establish a one-step multiplex PCR assay...
Quick diagnosis of smear-negative pulmonary tuberculosis (TB) and extra-pulmonary TB are urgently needed in clinical diagnosis. Our research aims to investigate the usefulness interferon-γ release assay (IGRA) for TB. We performed antibody TB-IGRA tests on 389 patients (including 120 smear-positive 269 patients), 113 patients, 81 with other diseases 100 healthy controls. Blood samples TB-Ab test were collected, processed, interpreted according manufacturer's protocol. The detection ratio...
In this study, male mice were treated with fermented and unfermented Lactobacillus plantarum, bulgaricus, rhamnosus black wolfberry juice (10 mL/kg/day) for 40 days, their prophylactic effects on ulcerative colitis (UC) induced by dextran sodium sulfate investigated. The intervention of reduced the levels pro-inflammatory cytokines increased content anti-inflammatory in serum colon. addition, pathological changes colon tissue alleviated, expression Bcl-2 protein was enhanced, intestinal...
Tuberculosis (TB) remains a great threat to global public health. The high biosafety level III required tackle its causative agent Mycobacterium tuberculosis seriously hinders the exploration of biology and new countermeasures. M. smegmatis is widely recognized good surrogate tuberculosis, largely due their conserved transcriptional machinery, sigma factors, two-component systems. However, distinct lifestyles often confound explanation results. leads both parasitic free life, while...
There is a significant survival difference and lack of effective treatment among breast cancer patients with liver metastasis. This present study aimed to construct novel prognostic score for predicting the prognosis locoregional benefit de novo metastatic metastasis (BCLM).In total, 2,398 eligible between 2010 2016 were selected from Surveillance, Epidemiology, End Results (SEER) database. They assigned training set including 1,662 (2010-2014) validation comprising 736 (2015-2016) depending...
To obtain information on the molecular mechanisms of insulin resistance (IR) in offspring rats due to maternal high‐fat diet exposure, we investigated (i) consequences consumption malprogramming that predisposes onset IR during adulthood and (ii) impact a myogenic adipogenic gene expression muscle. Sprague–Dawley female were randomly divided into two groups fed either normal chow (NC) or (HF). After breeding, pups four groups: male HF (MOH), (FOH), NC (MON) (FON). The until 18 weeks after...
As an effective drag reduction control method, porous media has received extensive attention in various engineering fields. In this paper, the large eddy simulation (LES) method is used to study flow problem around a cylinder with and without covering medium at subcritical Reynolds number. The characteristics mechanism of covered were studied. results aerodynamic coefficient show that: when number 5.6×10 4 , arranged on leeward side azimuth angle 270 degrees, rate largest, reaching 8.53%....
Purpose: Fatty acid metabolism plays an important role in the survival and pathogenesis of Mycobacterium tuberculosis . During dormancy, lipids are considered to be main source energy. A previous study found that Rv0494 is a starvation-inducible, lipid-responsive transcriptional regulator. However, bacterial persister has not been studied. Methods: We constructed deletion mutant strain H37Rv evaluated susceptibility antibiotics using persistence test. Results: mutations lead defects...