A5037346792- Urological Disorders and Treatments
- Sexual Differentiation and Disorders
- Urinary and Genital Oncology Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Pediatric Urology and Nephrology Studies
- MRI in cancer diagnosis
- Hernia repair and management
- Urologic and reproductive health conditions
- Kidney Stones and Urolithiasis Treatments
- Natural product bioactivities and synthesis
- Metabolism, Diabetes, and Cancer
- Neurological diseases and metabolism
- Pancreatic function and diabetes
- Medicinal Plant Pharmacodynamics Research
- Testicular diseases and treatments
- HER2/EGFR in Cancer Research
- Medical Imaging Techniques and Applications
- Intestinal Malrotation and Obstruction Disorders
- Neuroblastoma Research and Treatments
- Apelin-related biomedical research
- Ferroptosis and cancer prognosis
- Nuclear Receptors and Signaling
Children's Hospital of Zhejiang University
2019-2024
Soochow University
2014-2021
Guangdong Pharmaceutical University
2021
Zhejiang University
2021
Fuzhou General Hospital of Nanjing Military Command
2018
Fujian Medical University
2018
The First People's Hospital of Changzhou
2012-2017
Donghua University
2012-2015
Insulin degrading enzyme (IDE) is believed to act as a junction point of Type 2 diabetes (T2D) and Alzheimer's disease (AD); however, the underlying mechanism was not completely clear yet. Transgenic APPSwe/PS1 mice were used AD model treated with streptozocin/streptozotocin (STZ) develop mixed presenting both T2D. Morris Water Maze (MWM) recognition task performed trace cognitive function. The detection fasting plasma glucose (FPG) insulin concentration, oral tolerance test (OGTT)...
Type 2 diabetes (T2D) may play a relevant role in the development of Alzheimer's disease (AD), however, underlying mechanism was not clear yet. We developed an animal model presenting both AD and T2D, morris water maze (MWM) test recognition task were performed to trace cognitive function. Fasting plasma glucose (FPG) oral tolerance (OGTT) determined metabolism evolution. TUNEL assay apoptosis-related protein levels analyzed for detection neuronal apoptosis. Cyclic adenosine monophosphate...
To compare the characteristics of conventional laparoscopic pyeloplasty (LP) and robotic-assisted (RALP) in infants young children with ureteropelvic junction obstruction (UPJO).We performed a retrospective study patients (age: 0-36 months) who underwent dismembered (Anderson-Hynes) fourth-generation RALP or traditional LP between April 2020 December 2020.A total 33 UPJO were enrolled: 12 (9 left side; 3 right side) 21 (18 side). In group, median patient age was 17 months (range: 5-36...
Abstract Purpose 46,XY disorders of sex development (46,XY DSD) are characterized by incomplete masculinization genitalia with reduced androgenization. Accurate clinical management remains challenging, especially based solely on physical examination. Targeted next-generation sequencing (NGS) known pathogenic genes provides a powerful tool for diagnosis efficiency. This study aims to identify the prevalent genetic variants targeted NGS technology and investigate diagnostic rate in large...
Testicular tumors are uncommon in adults, accounting for <1% of all cancers, with testicular germ cell (TGCTs) representing the majority (>95%) reported cases. Adult and prepubertal TGCTs fundamentally distinct latter is extremely rare, 1% pediatric solid having an annual incidence rate 0.5-2/100,000 boys. Bilateral (BTGCTs) account 0.5-5% tumors; metachronous, while synchronous approximately 0.5-1%. A 16-month-old boy was admitted to our Urology Department a 2-week history painless scrotal...
The treatment of asymptomatic hydronephrosis due to ureteropelvic junction obstruction (UPJO), as well the timing and indications for surgical intervention, remain controversial.Diabetes insipidus (DI) is a rare disease in infants that known cause non-obstructive hydronephrosis, while its association with obstructive has not been reported.Some studies have found increased water intake predisposing risk factor developing hydronephrosis.However, there are no or guidelines indicate specific...
Since the first non-peptide Ang II receptor antagonist was originally reported, it has become most common target in development of new treatments for hypertension. In recent years, all components classical RAS have been reported prostate, these results suggest possibility that ARB is a novel therapeutic class agents prostate cancer. this study, compound 2-(4-((2-propyl-5-nitro-1H-benzo[d]imidazol-1-yl) methyl)-1H-indol-1-yl) benzoic acid synthesized and evaluated as angiotensin...
A new compound 2-(4-((2-butyl-5-nitro-1H-benzo[d]imidazol-1-yl)methyl)-1H-indol-1-yl) benzamide (1) was designed, synthesized and evaluated as a novel AT1 receptor antagonist. Compound 1 displayed high affinity to with an IC50 value of 1.65 ± 0.2 nM in radio-ligand binding assays. It had efficient long-lasting effect reducing blood pressure which could last for more than 12 h at the dose 10 mg/kg spontaneously hypertensive rats. Acute toxicity tests suggested that safe LD50 2519.81 mg/kg....
A variety of mutations in the androgen receptor (AR) gene are linked to insensitivity syndrome (AIS). AIS is most common specific cause 46, XY disorder sex development. Here, we reported a patient which presented as female with karyotype and normal external genitalia. The was diagnosed complete caused by novel mutation (NM_000044, c.2678-2726del, p. Pro893Leufs*35) AR gene. Targeted exome sequencing used detect patient's mutations. Sanger validate mutation. This study showed that can AIS;...
Objective To evaluate the changes of cerebral glucose metabolism before and after carotid artery stenting (CAS) in patients with asymptomatic stenosis.Methods Eleven patients,admitted to performed CAS our hospital from March 2010 December 2010,were enrolled.The received PET-CT examination 3 months (tracking by 18F-FDG).The max standardized uptake value (SUVmax) each supplement area was recorded region interest (ROI) method.The affected compared CAS,and unaffected one.Results The SUVmax...
Objective To study the influence of age,gender and history diabetes in maximum standardized uptake value (SUVmax) cerebral metabolic rate (SCMR) glucose.Methods Seventy-nine healthy volunteers were recruited evaluated by PET-CT examination.Region interest (ROI) analysis was employed to measure SUVmax 13 ROIs brain 13ROIs cerebellum.SCMR amounted left SUVmax/right corresponding ROI point each side same volunteer.The influences SCMR analyzed. Results No statistical significance noted between...
Objective To investigate the proper procedure for repairing different urethrocutaneous fistulas after primary urethroplasty hypospadias. Method There were 101 cases, whose age ranged from 27 months to 171 (mean 61 months), underwent fistula secondary hypospadiasis January 2010 December 2015. The methods of chosen mainly on site and size fistula, which included three types. coronal with a thin band tissue stretching between glans wings was classified as type I (n=24). For rest small at...
Objective The study was aimed to engineer a suitable microenvironment for islets survival. Methods The three-dimensional macroporous scaffold constructed with polydimethylsiloxane (PDMS) and sodium chloride crystal. The mini artificial pancreas engineered PDMS scaffold, bone marrow mesenchymal stroma cells (MSCs), fibronectin islets. pancreases were transplanted into the omentum of STZ-induced diabetic rats, while control group underwent sham operation. blood glucose level rats...
A routing strategy using nodes’ effective path and dynamic information weight distribution was proposed, which based on the improved efficient in complex network. The strategy’s factor optimized by new strategy, Considering insufficient of local strategies global performance community division technology network, a kind visibility according to thought presented. On condition Bgll condensation algorithm, topology structure neighbor nodes all were only stored each node’s list strategy....
Objective To evaluate the efficacy and approach of laparoscopic excision urachal remnants in children. Methods From May 2012 to April 2018, retrospective reviews were conducted for medical records all children undergoing remnants. Results There 10 boys 5 girls with a median age 4.5(0.3-16.8) years. Umbilicus-sparing was performed. The causes cyst (n=11) patent urachus (n=4). Complete conversion into open surgery & partial cystectomy (n=4) Postoperative antibiotics offered. All...
Objective To investigate the association between heme oxygenase-1 (HO-1) gene rs2071746 polymorphism and long-term clinical outcome in patients with ischemic stroke. Methods Between July 2015 June 2017, consecutive acute stroke admitted to Department of Neurology, Third Affiliated Hospital Soochow University were enrolled prospectively. TOAST classification was performed for all patients. Genotyping HO-1 using a modified multiplex ligase detection reaction technique. The followed up....
Objective To investigate the effect of a modified preputial flap urethroplasty in two-stage treatment severe hypospadias. Methods The clinical characteristics hypospadias patients (41 cases) who underwent staged by using procedure preset urethral plate with from January 2015 to December 2016 were analyzed retrospectively. We used method (modified group, 23 cases ): Form distal urethra transected tubularize incised (TIP) during first stage operation, after completely straightened...