A5085781252- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects of Natural Compounds
- Biopolymer Synthesis and Applications
- Tea Polyphenols and Effects
- Cholesterol and Lipid Metabolism
- Liver Disease and Transplantation
- Analytical Chemistry and Chromatography
- Protein Hydrolysis and Bioactive Peptides
- Traditional Chinese Medicine Analysis
- Enzyme Structure and Function
- Geotechnical Engineering and Underground Structures
- Antioxidant Activity and Oxidative Stress
- Organ Transplantation Techniques and Outcomes
- Microbial Metabolic Engineering and Bioproduction
- Cancer Research and Treatments
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Liver physiology and pathology
- Climate variability and models
- Retinoids in leukemia and cellular processes
- Enzyme Production and Characterization
- Amino Acid Enzymes and Metabolism
Nantong University
2025
Hubei Provincial Water Resources and Hydropower Planning Survey and Design Institute
2021-2024
Shaoxing University
2023
Zhejiang Pharmaceutical College
2011-2023
Tropical Bioscience and Biotechnology Research Institute
2022
Shanghai Jiao Tong University
2001-2018
Beijing Information Science & Technology University
2013
Dongbei University of Finance and Economics
2013
421 Hospital of PLA
2012
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2011
Endoplasmic reticulum (ER) stress is known to be involved in the development of several metabolic disorders, including non-alcoholic fatty liver disease (NAFLD). Tetracycline can cause hepatic steatosis, and ER may tetracycline-induced liver. Our previous study showed that bicyclol has been proven protect against mice, also bicyclol's hepatoprotective effect. Therefore, this was performed investigate underlying mechanisms associated with apoptosis, by which attenuated mice. Bicyclol (300...
Chimeric antigen receptor T-cell (CAR-T) therapy, which benefits from the perfect combination of gene editing techniques and antibody engineering, has shown outstanding clinical efficacy in hematological malignancies. Solid tumors present next challenge due to their extremely complicated microenvironment structural characteristics. Targeting efficiency persistence are currently bottleneck issues treatment CAR-T. Beyond drugs cytokines, biomaterials can modulate immune response, assisting...
Humans express two ACAT (acyl-CoA:cholesterol acyltransferase) genes, ACAT1 and ACAT2. is ubiquitously expressed, whereas ACAT2 primarily expressed in intestinal mucosa plays an important role cholesterol absorption. To investigate the molecular mechanism(s) responsible for tissue-specific expression of ACAT2, we identified five cis-elements within human promoter, four intestinal-specific transcription factor CDX2 (caudal type homeobox 2), one HNF1α (hepatocyte nuclear 1α). Results...
Acute liver failure (ALF) is a severe disease caused by many reasons. One of them the overdosed acetaminophen (APAP), which metabolized into N-acetyl-p-benzoquinone imine (NAPQI), an excessive toxic metabolite, CYP2E1, resulting in reactive oxygen species (ROS), exhausted glutathione (GSH), and thereafter hepatocyte necrosis. N-acetylcysteine Food Drug Administration-approved drug for detoxification APAP, but it has limited clinical application due to short therapeutic time window...
Hepatocellular carcinoma (HCC) has a high incidence and poor prognosis. Cuproptosis is novel type of cell death, which differs from previously reported types death such as apoptosis, autophagy, proptosis, ferroptosis, necroptosis, etc. Long non-coding RNAs (lncRNAs) play multiple roles in HCC.
During the aging process, dimers of dietary vitamin A accumulated in retinal pigment epithelium (RPE) cells. Vitamin dimer-mediated photooxidation resulted RPE apoptosis, which is associated with age-related degenerative disease retina, leading to blindness. It has been reported that proanthocyanidin-rich grape seed extract reduces oxidative stress eye. In this study, we investigated underlying mechanism photooxidation-induced apoptosis inhibition by procyanidins B2 (PB2), one main...
Aim: Bicyclol is a synthetic anti‐hepatitis drug with anti‐oxidative property. The purpose of this study was to investigate the effect bicyclol on hepatic ischemia/reperfusion (I/R) injury and related mechanisms. Methods: Rats were subjected 90 min ischemia followed by reperfusion for 1, 3, 6 24 h. Three doses orally administered before ischemia. Liver evaluated biochemical histopathological examinations. malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO), inducible...
The saponins, as components of tea seed meal, are undesirable hemolytic and should be degraded for reducing their activity in order to used animal feed. In this study, β-glucuronidase was verified a potent hydrolase saponins reduce β-glucuronidase-producing Lactobacillus crustorum strain screened from raw bovine milk. Next, solid-state fermentation with the isolated L. Bacillus subtilis natto strain, which can produce cellulase hence improve performance carried out detoxification meal. 50%...
Introduction: The pathological progression of non-alcoholic fatty liver disease (NAFLD) is driven by multiple factors, and steatohepatitis (NASH) represents its progressive form. In our previous studies, we found that bicyclol had beneficial effects on NAFLD/ NASH. Here aim to investigate the underlying molecular mechanisms effect NAFLD/NASH induced high-fat diet (HFD) feeding. Methods: A mice model HFD-feeding for 8 weeks was used. As a pretreatment, (200 mg/kg) given oral gavage twice...
Liver fibrosis results from chronic liver injury in conjunction with the accumulation of extracellular matrix proteins. The present study was performed to estimate effect bicyclol on bovine serum albumin (BSA)-induced immunological rats. Bicyclol (1) (100, 200, and 300 mg/kg) given rats by oral administration once a day for 5 weeks fourth week intravenous injection BSA. Blood tissues were collected measurement hydroxyproline (Hyp), procollagen type III (PIIIP), hyaluronic acid (HA),...
Non-alcoholic fatty liver disease (NAFLD) is a manifestation of the metabolic syndrome in liver, and non-alcoholic steatohepatitis (NASH) represents its advanced stage. Bicyclol has protective activity against NAFLD mice; however, effect bicyclol on high-fat diet (HFD)-induced NASH underlying molecular mechanism remains unknown particularly anti-endoplasmic reticulum (ER) stress autophagic machinery potentials. Therefore, present study was performed to investigate mechanisms action...
Acid stress is a challenging condition that yeast cells must overcome during fermentation. Enhancing the inherent tolerance of industrial Saccharomyces cerevisiae to organic acid stresses crucial for increasing fermentation efficiency and reducing economic costs. In previous study, we constructed strain SWY85S with improved citric by modifying second PEP4-allele. Malic dominant in grapefruit, which forms acidic constituents wine mash finished products. We investigated malic comparison one...
Huo-Xue-Qu-Yu formula (HXQYF) is a prescription consisting of Ginkgo biloba leaf and Paeonia lactiflora Pall. for treating hyperlipidemia NAFLD in China. Here, we investigated the hepatic renal function, oxidative stress lipid metabolism, potential mechanisms HXQYF on nonalcoholic fatty liver disease (NAFLD) rat models. models were induced with high-fat diet (HFD) 10% fructose water 18 weeks orally administered or without simultaneously. The results showed that (22.5, 45, 90 mg/kg)...