A5100378402- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Hemoglobin structure and function
- Pancreatic function and diabetes
- Muscle metabolism and nutrition
- RNA regulation and disease
- Liver Disease Diagnosis and Treatment
- Plant Virus Research Studies
- Machine Learning and Algorithms
- Neurological Disease Mechanisms and Treatments
- Axon Guidance and Neuronal Signaling
- Viral gastroenteritis research and epidemiology
- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Cancer-related gene regulation
- Barrier Structure and Function Studies
- Aortic aneurysm repair treatments
- Text and Document Classification Technologies
- Hepatitis C virus research
- Neonatal Health and Biochemistry
- Cancer Immunotherapy and Biomarkers
- Erythrocyte Function and Pathophysiology
- Cellular transport and secretion
- Transgenic Plants and Applications
Shandong University of Finance and Economics
2024
Chongqing Academy of Animal Science
2024
Denali Therapeutics (United States)
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Sir Run Run Shaw Hospital
2022-2023
Zhejiang University
2010-2023
East China Normal University
2022
Chinese Academy of Agricultural Sciences
2022
Zhengzhou University
2022
Ningbo University Affiliated Hospital
2022
The rapid developments in nanotechnology have brought with them a deep concern over the safety of nanomaterials. Investigating molecular mechanisms underlying their toxicity different cell lines will help us better understand and apply nanomaterials appropriately. Poly(ethylene glycol)-phosphoethanolamine (PEG-PE) is an FDA-approved nonionic diblock copolymer widely used drug delivery systems. Here, we find that PEG-PE accumulates endoplasmic reticulum (ER) induces ER stress cancer cells...
Bioactive protein hydrolysates and peptides are believed to help counteract ameliorate physical fatigue. Fermented soybean (FSPPs) were prepared by protease hydrolysis microbial fermentation. The present study aimed evaluate the anti-fatigue properties of FSPPs.The forced swimming time in FSPP group was 35.78% longer than control group, oxygen-resistant survival significantly prolonged prolongation rate 31.00%. In addition, FSPPs decreased lactic acid (LD), blood urea nitrogen (BUN) creatine...
Due to the high morbidity and mortality of fulminant hepatitis, early diagnosis followed by effective treatment is key for prognosis improvement. So far, little known about gene expression changes in stage this serious illness. Identification genes related very hepatitis development may provide precise clues diagnosis. Balb/C mice were used ConA injection induce that was confirmed pathological biochemical examination. After a chip-based screening, data liver, further dissected ANOVA...
Objective: Metastasis and therapeutic resistance are the major determinants of lung cancer progression high mortality. Epithelial-mesenchymal transition (EMT) plays a key role in metastasis resistance. Highly expressed glucose-regulated protein 78 (GRP78) is poor prognostic factor possibly correlated with EMT. This study aims to examine whether up-regulation GRP78 involved EMT adenocarcinoma explore underlying downstream molecular pathways. Study Design: was assessed by analysis cell...
The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that activated to multiple sources of cellular stress. Although acute activation this restores homeostasis, intense or prolonged ISR perturbs cell function and may contribute neurodegeneration. DNL343 an investigational CNS-penetrant small molecule inhibitor designed activate the initiation factor 2B (eIF2B) suppress aberrant activation. reduced CNS activity neurodegeneration dose-dependent manner two established...
Diabetic cardiomyopathy is a common complication of diabetes, in which endoplasmic reticulum stress (ERS) serves an important role. Rutin can treat the myocardial dysfunction diabetic rats. However, to best our knowledge, studies on effects injury caused by diabetes from perspective ERS have not previously been reported. In present study, role rutin regulation was assessed. Different high glucose concentrations were used H9C2 myoblast cells establish damage model. A cell counting kit-8 assay...
Neuroglobin (NGB) is a recently identified protein, which localized in the neurons and retinal cells of central peripheral nervous systems vertebrates. It hypothesized to function as scavenger for reactive oxygen species, or stress‑responsive sensor signal transduction hypoxic‑ischemic brain insults. However, mechanism underlying physiological this protein remains be elucidated. In present study, profiling changes serum redox index morphological features hippocampus cortex, expression NGB...
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Secretory leukocyte protease inhibitor (SLPI) has been reported to function as a regulatory factor in several cancers. However, its biological functions and underlying mechanisms HCC remain be uncovered. Here, we aimed explore effect SLPI HCC. In our study, found that mRNA protein expression levels were significantly down-regulated tissues hepatoma cell lines low level predicted worse survival cohorts. term...
Non-alcoholic fatty liver disease (NAFLD) is a manifestation of the metabolic syndrome in liver, and non-alcoholic steatohepatitis (NASH) represents its advanced stage. Bicyclol has protective activity against NAFLD mice; however, effect bicyclol on high-fat diet (HFD)-induced NASH underlying molecular mechanism remains unknown particularly anti-endoplasmic reticulum (ER) stress autophagic machinery potentials. Therefore, present study was performed to investigate mechanisms action...
AIM:To study the effects of QHF-cisplatin on H22 hepatocellular carcinoma (HCC) and their mechanisms action. METHODS:Sixty BALB/c mice were randomly divided into a model group (n = 48) normal control 12).An HCC xenograft tumor was created by injecting cells directly liver parenchyma mice.The 48 in four groups: QHF, DDP (cisplatin), QHF plus DDP, control.The inhibitory these drugs growth evaluated calculating rate inhibition.The examined observing general condition, body weight survival...
Alzheimer's disease (AD) is a neurological disorder characterized by neuronal cell death, tau pathology, and excessive inflammatory responses. Several vascular risk factors contribute to damage of the blood-brain barrier (BBB), secondary leak-out blood vessels, infiltration cells, which aggravate functional disability pathological changes in AD. Growth factor angiopoietin-1 (Ang-1) can stabilize endothelium reduce endothelial permeability binding receptor tyrosine kinase 2 (Tie2). C16...
Abstract Background Resolvin D1 (RvD1), a specialized pro-resolving lipid mediator (SPM), is derived from docosahexaenoic acid (DHA). It plays key role in actively resolving inflammatory responses, which further reduces small intestinal damage. However, its regulation of the apoptosis triggered by endoplasmic reticulum (ER) stress epithelial cells still poorly understood. The porcine (IPEC-J2) were stimulated with tunicamycin to screen an optimal stimulation time and concentration establish...
Liver transthyretin (TTR) synthesis and release are exacerbated in insulin-resistant states but decreased by exercise training, relation to the insulin-sensitizing effects of exercise. We hypothesized that TTR knockdown (TTR-KD) may mimic this exercise-induced metabolic improvement skeletal muscle remodeling. Adeno-associated virus-mediated TTR-KD control mice were trained for 8 weeks on treadmills. Their metabolism status capacity investigated then compared with sedentary controls. After...
Neuroglobin (Ngb) is a globin with high affinity to oxygen and specifically expressed in the brain of vertebrates. Many studies show that Ngb's expressions change it may have protective effects nervous system injury, such as ischemia/hypoxia. Mechanisms role include free radicals scavenging, anti-oxidative stress, well anti-apoptosis. Ngb can also play transduction signal increase downstream phosphatidylinositol-3-kinase/protein serine threonine kinase (PI3K/AKT) activities. Arsenic exposure...
Objective To investigate the mechanism of microRNA (miRNA, miR)-29b regulation tribbles pseudokinase 2 (TRIB2) in colorectal tumors. Methods The online database was used to analyze miRNAs that bind 3’Untranslated Region (UTR) TRIB2, and highest scored miR-29b selected for study. The eukaryotic cell transfection technique interfere with expression tumor cells; Western blotting real-time quantitative polymerase chain reaction (Real-time PCR) detect difference protein mRNA TRIB2;...