A5069879730- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Silk-based biomaterials and applications
- Alcohol Consumption and Health Effects
- Radar Systems and Signal Processing
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Pesticide Residue Analysis and Safety
- Synthesis and biological activity
- Neurological Disease Mechanisms and Treatments
- Synthesis and Reactivity of Heterocycles
- Autophagy in Disease and Therapy
- Biochemical effects in animals
- Antenna Design and Optimization
- Analytical Chemistry and Chromatography
- Diet, Metabolism, and Disease
- X-ray Diffraction in Crystallography
- Multicomponent Synthesis of Heterocycles
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Direction-of-Arrival Estimation Techniques
- RNA Interference and Gene Delivery
Zhejiang Pharmaceutical College
2020-2023
Ningbo University
2022
Guangdong Pharmaceutical University
2019
Xuzhou Medical College
2017
Dalian University
2016
Beijing Institute of Radio Metrology and Measurement
2016
Putian University
2016
Dalian University of Technology
2014
Hepatocellular carcinoma (HCC) has a high incidence and poor prognosis. Cuproptosis is novel type of cell death, which differs from previously reported types death such as apoptosis, autophagy, proptosis, ferroptosis, necroptosis, etc. Long non-coding RNAs (lncRNAs) play multiple roles in HCC.
Abstract Objective The purpose of this study was to evaluate the effect astaxanthin (AST) on cognition function, inflammatory response and oxidative stress in vascular dementia (VD) mice. Method VD mice model established by left unilateral common carotid arteries occlusion (LUCCAO). Following LUCCAO, AST intragastrically administered for 30 days. Object recognition test morris water maze were used cognitive function. Hematoxylin eosin staining performed observe hippocampal neuron structure....
Introduction: The pathological progression of non-alcoholic fatty liver disease (NAFLD) is driven by multiple factors, and steatohepatitis (NASH) represents its progressive form. In our previous studies, we found that bicyclol had beneficial effects on NAFLD/ NASH. Here aim to investigate the underlying molecular mechanisms effect NAFLD/NASH induced high-fat diet (HFD) feeding. Methods: A mice model HFD-feeding for 8 weeks was used. As a pretreatment, (200 mg/kg) given oral gavage twice...
A highly regioselective acid-catalyzed three-component reaction of 2-aminopyridine and 3-phenylpropiolaldehyde for the construction imidazo[1,2-a]pyridine has been developed. This strategy provides a broad range substrates represents an efficient approach to give various 2-aminopyridine-decorated in good yields.
Non-alcoholic fatty liver disease (NAFLD) is a manifestation of the metabolic syndrome in liver, and non-alcoholic steatohepatitis (NASH) represents its advanced stage. Bicyclol has protective activity against NAFLD mice; however, effect bicyclol on high-fat diet (HFD)-induced NASH underlying molecular mechanism remains unknown particularly anti-endoplasmic reticulum (ER) stress autophagic machinery potentials. Therefore, present study was performed to investigate mechanisms action...
To investigate the underlying mechanism of hepatic sinusoidal obstruction syndrome (HSOS) induced by Gynura segetum measuring autophagy in mouse models.The model group was administered G. (30 g/kg/d) gavage, while normal control an equal volume saline daily for five weeks. Serum alanine aminotransferase (ALT), aspartate (AST), histopathological examinations, and Masson staining were performed to evaluate liver injury. Liver intercellular adhesion molecule-1 (ICAM-1) P-selectin evaluated...
Hepatitis B virus (HBV) DNA polymerase transactivated protein 1 (HBVDNAPTP1) is a novel upregulated by HBV polymerase, which has been screened suppression subtractive hybridization technique (SSH) (GenBank Acc.No. AY450389).A vector pcDNA3.1 (-)/myc-His A-HBVDNAPTP1 was constructed and used to transfect acute monocytic leukemia cell line THP-1.HBVDNAPTP1 expression detected Western blot analysis in the cells.A cDNA library of genes downregulated HBVDNAPTP1 THP-1 cells made pGEM-T Easy using...
Abstract Background: Hepatocellular carcinoma (HCC) has a high incidence and poor prognosis. Cuproptosis is novel type of cell death, which differs from previously reported types death such as apoptosis, autophagy, proptosis, ferroptosis, necroptosis, etc. Long non-coding RNAs (lncRNAs) play multiple roles in HCC. To improve the prognosis HCC, it necessary to construct signature using cuproptosis-related lncRNAs. Methods: We downloaded information including RNA-seq transcriptome, clinical...
The purpose of this study is to establish a new method for detecting nicotinamide concentration in plasma. In the experiment, high performance liquid chromatography (HPLC) was used, with fluorescence detector. plasma first converted N1- methylnicotinamide, then reacted acetophenone under certain conditions produce fluorescent derivatives testing. kind highly sensitive detection, which lower limit 10 ng/mL, recovery rate between 92.75% and 105.13%, relative standard deviation (RSD) 3.76%...
Objective By observing the effect of artesunate(ART) on airway remodeling in asthmatic rats, and to investigate its relationship with TGF-β1-smad2/3 signaling pathway. Methods Clean level 32 male SD rats were randomly divided into control group, asthma dexamethasone ART 8 each way using excitation atomization inhalation model was established, treated drug.To observe pathological changes lung tissue Image-Pro plus 6 image analysis software measure thickness bronchial wall smooth muscle...