Hyperbaric oxygen (HBO) therapy is an effective for ischemia/reperfusion (I/R) injury of the brain, small intestine, testes and liver. However, detailed molecular mechanisms underlying effect HBO remain undetermined. In current study, hypothesis that preconditioning rats with protects grafted skin flaps against subsequent I/R was investigated. addition, were characterized by analyzing roles following important inflammatory factors: High mobility group protein 1 (HMGB1) nuclear factor-κ B...

Background Amantadine is currently recommended for use in patients of post-traumatic brain injury with unresponsive wakefulness syndrome (UWS). However, the application amantadine UWS after cerebral hemorrhage has only been rarely reported. This allows a further exploration role treatment resulting from severe hemorrhage.Methods We observed changes seven intracerebral taking amantadine. also carried out detailed neurological examination patient disorders consciousness to include or exclude...

Accumulating studies have demonstrated that hyperbaric oxygen (HBO) treatment alleviates spinal cord injury (SCI). However, the underlying mechanism by which HBO SCI remains to be elucidated. In this study, we performed genome-wide transcriptional profiling of between mice and received high-throughput RNA sequencing at 1 week after SCI. We also compared profiles from sham-operated mice. found 76 differentially co-expressed genes in mice, HBO-treated Using Gene Ontology Kyoto Encyclopedia...

The clinical application of hyperbaric oxygen therapy (HBOT) in spinal cord injury (SCI) has been reported, however the mechanism underlying its therapeutic effects remains to be elucidated. In present study, SCI was modeled male Sprague‑Dawley rats. A total 120 rats were randomly divided into four groups: Sham‑operated group (SH); sham‑operated and (SH+HBO); treatment (SCI+HBO). each five smaller groups (12 h, 1, 3, 7 14 days after surgery). mRNA protein expression levels NACHT domain‑,...

The inflammatory response is an important source of secondary damage to neuronal tissue in the spinal cord following injury (SCI). Hyperbaric oxygen (HBO) therapy reduces inflammation and promotes restoration locomotor function SCI, however, mechanisms underlying this effect remain be determined. aim current study was investigate by which HBO recovery a rat model SCI measuring expression levels receptor for advanced glycation end products (RAGE) monocyte chemoattractant protein‑1 (MCP‑1)...

Study Design. Experimental animal study of treatment SCI. Objective. To explore whether HBO protects against secondary SCI by inhibiting the ER stress response. Summary Background Data. is a neurological disorder that can severely limit execution simplest day-to-day functions. plays an important role in induction neuronal apoptosis after alleviate injury and benefit recovery SCI, but effect on response yet to be characterized. Methods. The spinal cord rats was injured via T10 laminectomy....

Disruption of the intestinal epithelial barrier following spinal cord injury (SCI) seriously affect long-term quality life. Oxidative stress-induced cells' contributes to dysfunction. Hyperbaric oxygen (HBO) treatment has been proved alleviate SCI. However, it is unclear whether or not HBO affects function In this study, our purpose was explore impact on and underlying mechanisms An SCI model established in rats, rats received treatment. Intestinal injury, mucosal permeability, intercellular...

By observing the dynamic changes of extracellular histones H1, H2A, H4, and NF-κB expression in brain tissues after injury rats, we explore association among following traumatic (TBI), as well effect different atmospheres absolute hyperbaric oxygen (HBO) intervention on possible mechanisms. A total 120 SD rats were randomly divided into 4 groups: Sham-operated (SH), TBI (traumatic injury) group, treatment 1.6ATA (TBI + HBO1) treatment2.2ATA HBO2) with 30 each group. The group then five...

Background: The neurological defect caused by secondary damage following traumatic brain injury (TBI) is considered critical for the management of TBI. Microglia (MG) are a resident macrophage that could differentiate into M1 type or M2 in response to and repair. It known MG transition from phenotype anti-inflammatory might reduce So, TBI animal model was established we compared biomarkers M2MG between controls experimental animals receiving hyperbaric oxygen therapy (HBOT). This study aimed...

Intestinal barrier dysfunction is often observed clinically after spinal cord injury (SCI) and seriously affects long-term quality of life. Hyperbaric oxygen (HBO) treatment has been proved to promote function recovery injury, but the influence HBO on intestinal following SCI unclear. We aimed investigate effect mechanisms by measuring level tight junction (TJ) proteins Ras homolog (Rho)/Rho associated coiled-coil forming protein kinase (ROCK) signaling pathway. model was established in...

Objective: To investigate the effects of sequential nutritional support on status and immune regulation in patients with early severe traumatic brain injury (STBI). Patients methods: A total 62 diagnosed STBI enrolled from Chaoyang Hospital (Beijing, China) February 2015 to October 2016 were divided into two groups. The observational group (n=34) was given control (n=28) standard formula whole protein enteral preparations. energy supply for groups 30 kcal/kg/d 1.6 g/kg/d, respectively....

Hyperbaric oxygen (HBO) is known to increase the survival of skin flaps by promoting neovascularization; however, detailed mechanisms involved are not fully understood. In present study, we aimed characterize effects HBO treatment on neovascularization and flap survival. We also analyzed associated with expression angiogenic molecules, such as stromal cell derived factor-1 (SDF‑1) its specific receptor CXCR4, assess SDF-1 CXCR4 promotion in flaps. The epigastric pedicle model was established...

The gut microbiota is believed to be directly involved in the etiology and development of chronic liver diseases. However, holistic characterization bacteriome, mycobiome, virome patients with hepatitis B-related fibrosis (CHB-LF) remains unclear.

Basic science study investigating the potential molecular mechanisms of hyperbaric oxygen (HBO) therapy in mice with spinal cord injury (SCI).We aimed to explore intrinsic HBO for SCI through lens ferroptosis subacute phase.HBO has been observed facilitate restoration neurological function subsequent SCI. Ferroptosis is a distinct cellular death mechanism that can be distinguished from apoptosis, necrosis, and autophagy. However, precise relationship between these two phenomena remains...