A5006180881- Adsorption and biosorption for pollutant removal
- Anesthesia and Pain Management
- Chromium effects and bioremediation
- Neurological Disease Mechanisms and Treatments
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury and Neurovascular Disturbances
- Minerals Flotation and Separation Techniques
- RNA modifications and cancer
- Biochemical effects in animals
- Anesthesia and Neurotoxicity Research
- Cytomegalovirus and herpesvirus research
- Circular RNAs in diseases
- Autoimmune and Inflammatory Disorders Research
- Atherosclerosis and Cardiovascular Diseases
- Phytochemistry and Biological Activities
- Heavy metals in environment
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Natural product bioactivities and synthesis
- Bacteriophages and microbial interactions
- Analytical chemistry methods development
- Colorectal Cancer Surgical Treatments
Xiangya Hospital Central South University
2024-2025
Central South University
2024-2025
Zhejiang University
2021-2025
State Key Laboratory of Clean Energy Utilization
2023-2025
Clean Energy (United States)
2025
Weifang Medical University
2025
Shanxi Medical University
2014-2024
Shanxi Academy of Medical Sciences
2024
China University of Geosciences (Beijing)
2017-2022
China Academy of Engineering Physics
2022
Purpose: Long non-coding RNAs (lncRNAs) play key roles in human cancers. Here, FEZF1-AS1, a highly overexpressed lncRNA colorectal cancer, was identified by microarrays. We aimed to explore the and possible molecular mechanisms of FEZF1-AS1 cancer.Experimental Design: LncRNA expression cancer tissues measured microarray qRT-PCR. The functional were demonstrated series vitro vivo experiments. RNA pull-down, immunoprecipitation luciferase analyses used demonstrate potential FEZF1-AS1.Results:...
In this study, the adsorption capacities of peanut shell activated carbon samples prepared using three types as raw material were compared. The effects activation state, carbonization temperature, time, time during decolorization, and dosage on performance investigated. modified (activated carbon) decolorization reactive brilliant blue X-BR kinetics evaluated systematically. Among carbon, that was first by phosphoric acid then carbonized at 450°C for 3 h displayed best performance, with an...
The combination of ferroptosis inducers and immune checkpoint blockade can enhance antitumor effects. However, the efficacy in tumors with low immunogenicity requires further investigation. In this work, a water-in-oil Pickering emulsion gel is developed to deliver (1S, 3R)-RSL-3 (RSL-3), inducer dissolved iodized oil, programmed death-1 (PD-1) antibody, most commonly used inhibitor water, optimal characteristics (RSL-3 + PD-1@gel). Tumor lipase degrades continuous oil phase, which results...
Abstract The incidence and death rate of colorectal cancer ( CRC ) is very high, which brings great need to understand the early molecular events . These studies demonstrate that long noncoding RNA (lnc plays an important role in occurrence development human cancer. Small nucleolar host gene 15 SNHG 15) was recently identified as a cancer‐related lnc In this study, we aimed evaluate function mechanism expression detected by quantitative RT ‐ PCR qRT tissues matched noncancerous NCT s). CCK...
The transcription factor HNF4α (hepatocyte nuclear factor-4α) is required for increased β-cell proliferation during metabolic stress in vivo. We hypothesized that could induce of human β-cells. employed adenoviral-mediated overexpression an isoform (HNF4α8) alone, or combination with cyclin-dependent kinase (Cdk)6 and Cyclin D3, islets. Heightened HNF4α8 expression led to a 300-fold increase the number β-cells early S-phase. When we overexpressed together Cdk6 cycle entry was even further....
There has been no report on enzyme-controlled disassembly of self-quenched NIR fluorescent nanoparticles turning fluorescence for specific detection/imaging the enzyme's activity in vitro and vivo. Herein, we reported rational design new probe 1 whose signal was upon reduction-controlled condensation subsequent assembly its (i.e., 1-NPs). Then 1-NPs by furin turned on. Employing this enzymatic strategy, successfully applied detection imaging living cells. Moreover, also discriminative...
This study aimed to explore the clinical efficacy of Ginkgo biloba combined with Nicorandil in patients heart failure who have a mild decrease ejection fraction (HFmrEF).A total 316 HFmrEF were selected and randomly assigned either control group or combination group, each consisting 158 patients. The received standard secondary preventive treatment, while oral based on stable conventional treatment. Both groups treated continuously for six months. age, sex, body mass index (BMI), New York...
This study investigated the impact of lidocaine-induced neurotoxicity on microRNA (miRNA) expression in spinal cord rats. Sprague-Dawley rats underwent intrathecal catheterization and were randomly assigned to receive either 10% lidocaine or normal saline for three consecutive days. Post-treatment, paw withdrawal threshold significantly increased, accompanied by notable histopathological changes. Additionally, 470 miRNAs exhibited altered following treatment, with miR-155-5p, miR-3544,...
Nanoparticles (NPs) are promising tools in biomedical applications. Their unique physicochemical properties, such as controllable size, tunable shape and versatile surface functionality, provide significant advantages targeted delivery controlled release. Despite of the large progress, NP‐based drug systems still face a major challenge, i.e. NPs often demonstrate less therapeutic improvements than expectation. The disparity mainly arises from incomplete understanding NP behaviors complex...
A colorimetric sensor for nitrite ion with high selectivity and sensitivity by unmodified citrate-capped gold nanoparticles (Au NPs) is presented. Recognition of developed on the basis a highly specific diazo reaction between phenylenediamine (PDA). PDA caused Au NPs to aggregate owing strong covalent NH–Au bond, clear color change solution from red blue being visualized. In presence phosphoric acid nitrite, amines would readily be converted bonds, was observed after subsequent addition...
Colorectal cancer (CRC) is one of the most common cancers worldwide, whose morbidity and mortality gradually increased. Here, we aimed to identify access prognostic long non-coding RNAs (lncRNAs) associated with overall survival (OS) in CRC. Firstly, RNA expression profiles were obtained from The Cancer Genome Atlas (TCGA) database, 439 CRC patients enrolled as a training set. Univariate Cox analysis least absolute shrinkage selection operator (LASSO) performed lncRNAs. Multivariable...
Abnormal activation of pancreatic stellate cells (PSCs) plays a crucial role in the pathogenesis chronic pancreatitis (CP). Irisin, an exercise-induced hormone, has been shown to mitigate liver fibrosis by inhibiting hepatic cells. However, effect irisin CP not evaluated. This study aimed determine whether is protective CP. was induced 6 IP injections cerulein (50 μg/kg/body weight). HPSCs were treated with 5 ng/ml TGF-β1 as vitro experiment. Our results showed that repeated injection severe...
Hyperforin is a major active constituent of Hypericum perforatum L. extract, which widely used for the treatment depressive disorders. Recent studies have reported that hyperforin reduced inflammation in stroke and suppressed proliferation differentiation keratinocytes. Psoriasis chronic immune-mediated inflammatory skin disease IL-23/IL-17 axis plays an important role. To investigate underlying mechanisms response psoriasis, we use imiquimod (IMQ)-induced mice model, vitro cultured murine...
Joint therapy is a promising area of study in cancer treatment. In this paper, we prepared Mn–Zn ferrite (Mn0.5Zn0.5Fe2O4) magnetofluid using PEI as surfactant, and investigated the anticancer effect Mn0.5Zn0.5Fe2O4 magnetic fluid hyperthermia (MFH) combined with radiotherapy on hepatocellular carcinoma. Both vitro vivo results suggest that treatment MFH radiation has better therapeutic than either them alone. The apoptotic rate necrotic group was 38.80 25.20%, respectively. contrast, it...