A5073675400- Cancer-related molecular mechanisms research
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Advanced Image Fusion Techniques
- Esophageal Cancer Research and Treatment
- Remote-Sensing Image Classification
- Coronary Interventions and Diagnostics
- Image and Signal Denoising Methods
- Esophageal and GI Pathology
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- Cancer survivorship and care
- Testicular diseases and treatments
- Protease and Inhibitor Mechanisms
- Supramolecular Self-Assembly in Materials
- Radiomics and Machine Learning in Medical Imaging
- Sarcoidosis and Beryllium Toxicity Research
- Autophagy in Disease and Therapy
Jiangnan University
2015-2025
Dazhou Academy of Agricultural Sciences
2024
Wuxi Fourth People's Hospital
2014-2023
Wuxi No.2 People's Hospital
2018
The Fourth People's Hospital
2017
Soochow University
2010-2013
Affiliated Hospital of Nantong University
2011
Nantong University
2011
Piperlongumine (PL), a natural alkaloid present in the fruit of Long pepper, is known to exhibit notable anti-cancer effects. Nonetheless, anti-tumor effect PL lung cancer cells still remains unclear. In study, we reported chemotherapeutic effects using vitro and vivo models. We showed that displayed potent anti-neoplastic activity against A549 as well corresponding docetaxel-resistant A549/DTX cells. addition, found induced apoptosis both also autophagy Moreover, autophagy-specific...
The lack of cancer cell specificity and the occurrence multidrug resistance (MDR) are two major obstacles in treatment hepatocellular carcinoma (HCC). To tackle these challenges, a novel nanoparticle (NP)-based drug delivery system (DDS) with core/shell structure consisted d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-galactose (Gal)/polydopamine (PDA) is fabricated. NP loaded doxorubicin (DOX) nitric oxide (NO) donor
Abstract The incidence and death rate of colorectal cancer ( CRC ) is very high, which brings great need to understand the early molecular events . These studies demonstrate that long noncoding RNA (lnc plays an important role in occurrence development human cancer. Small nucleolar host gene 15 SNHG 15) was recently identified as a cancer‐related lnc In this study, we aimed evaluate function mechanism expression detected by quantitative RT ‐ PCR qRT tissues matched noncancerous NCT s). CCK...
The aorta contains numerous cell types that contribute to vascular inflammation and thus the progression of aortic diseases. However, heterogeneity cellular composition ascending in setting a high-fat diet (HFD) have not been fully assessed. We performed single-cell RNA sequencing on aortas from mice fed normal HFD. Unsupervised cluster analysis transcriptional profiles 24,001 cells identified 27 clusters representing 10 types: endothelial (ECs), fibroblasts, smooth muscle (SMCs), immune (B...
Although programmed death-ligand 1 (PD-L1) inhibitors have achieved efficacy in cancer therapy, their response rate is low. Differences the prognosis of patients with under anti-PD-L1 treatment are related to PD-L1 level tumors. Accurate detection can optimize accuracy tumor immunotherapy and avoid ineffective clinical diagnosis treatments.
ABSTRACT Lung adenocarcinoma (LADC) is the most common lung cancer and leading cause of cancer-related deaths globally. Accumulating evidence suggests that gut microbiota regulates host response to chemotherapeutic drugs can be targeted reduce toxicity current agents. However, effect Diaphorobacter nitroreducens synergized with oxaliplatin on their impact LADC have never been explored. This study aimed evaluate anti-cancer effects D. , oxaliplatin, combined treatment tumor growth in...
BACKGROUND Esophageal cancer (EC) is an aggressive malignancy with low survival (10%-30%). Nutritional problems are present throughout the perioperative period and key to prognosis. Home enteral nutrition appears improve nutritional status of patients EC. Few studies have addressed experience administering their own fluids managing feeding tubes at home. The aim this study was explore real-life self-management in home after EC surgery first 3 months discharge following surgery. AIM To tube...
Purpose: Long noncoding RNAs (lncRNAs) have recently received more attention for their roles in tumor progression.LINC00261 was studied this research to identify how it affects the progression of non-small cell lung cancer (NSCLC).Methods: Firstly, expression LINC00261 NSCLC cells and paired samples tissue detected by RT-qPCR.Then, associations between level clinicopathological characteristics were evaluated.Furthermore, functional assays proliferation, colony formation transwell, as well...
Matrices formed by self-assembly of amino acids and their derivatives are suitable for cell spreading, migration proliferation, widely used in tissue engineering organ regeneration, due to the biological endogenous molecules weak intermolecular forces. The process is not only affected dynamic thermodynamic factors, but also assembled space. In this work, capillary tubes with different diameters chosen mimic a confined environment effect space on behavior Fmoc-amino oil-water partition...
Although most studies proved that thoracic esophageal cancer surgery with supraclavicular lymph nodes (SCLNs) metastasis could benefit, less than 30% of the 5-year survival rate remained controversy on its surgical treatment. In this study, we aimed to analyze prognosis SCLNs different segments cancer, which will supply a reference for treatment disease.Retrospectively collected clinical data 163 patients squamous (ESCC) and compared effects in segments.Patients had worse negative group...
Abstract Background Little is known about noncoding oncogenes of lung adenocarcinoma (LUAD), and these potential drivers might provide novel therapeutic targets. Methods Since abnormally overexpression oncogenic induced by genomic variation, we here utilized genomic, transcriptomic, clinical prognosis data The Cancer Genome Atlas (TCGA) LUAD datasets to discover from long RNAs. We further used zebrafish models validate the biological function candidates in vivo. full length FAM83H‐AS1 was...
Purpose . To compare the differential diagnostic values of 18 F-Alfatide II PET/CT between tuberculosis and lung cancer patients in with sarcoidosis common inflammation. Methods Nine inflammation (4 tuberculosis, 3 sarcoidosis, 2 inflammation) 11 were included this study. All underwent F-FDG within weeks, followed by biopsy surgery. The maximized standard uptake value (SUVmax) mean (SUVmean) evaluated. Results active lesions showed a high accumulation F-FDG, but varying degrees II, including...
investigate the timing of assessing maturation arteriovenous fistula (AVF) and diagnostic efficacy two ultrasound assessment criteria in determining AVF.
Abstract False positive reduction is a key procedure of computer‐aided pulmonary nodule detection. The goal to recognize the true from plentiful candidates, which received first step candidate Convolutional networks can be used perform false reduction, but classification accuracy need further improved. Recently, residual network more and popular around world with its distinguished performance. A multicontext three‐dimensional convolutional neural (3D Res‐CNN) was proposed realize nodule....