A5101422276- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Phosphodiesterase function and regulation
- Cholinesterase and Neurodegenerative Diseases
- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Water resources management and optimization
- Ovarian cancer diagnosis and treatment
- Insect and Pesticide Research
- Cancer-related molecular mechanisms research
- Plant and animal studies
- CRISPR and Genetic Engineering
- Signaling Pathways in Disease
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Insect and Arachnid Ecology and Behavior
- Genetic factors in colorectal cancer
- Receptor Mechanisms and Signaling
- RNA Research and Splicing
- Tryptophan and brain disorders
- Plant Virus Research Studies
- PARP inhibition in cancer therapy
- Genomics and Rare Diseases
- Chemical synthesis and alkaloids
Ospedale Policlinico San Martino
2019-2023
The University of Texas Rio Grande Valley
2022
University of Genoa
2014-2017
High levels of amyloid-β peptide (Aβ) have been related to Alzheimer's disease pathogenesis. However, in the healthy brain, low physiologically relevant concentrations Aβ are necessary for long-term potentiation (LTP) and memory. Because cGMP plays a key role these processes, here we investigated whether cyclic nucleotide influences function during LTP We demonstrate that increase by phosphodiesterase-5 inhibitors sildenafil vardenafil induces parallel release due change approximation...
Cyclic adenosine monophosphate (cAMP) regulates long‐term potentiation (LTP) and ameliorates memory in healthy diseased brain. Increasing evidence shows that, under physiological conditions, low concentrations of amyloid β (Aβ) are necessary for LTP expression formation. Here, we report that cAMP controls precursor protein (APP) translation Aβ levels, the modulatory effects on occur through stimulation APP synthesis production. Ann Neurol 2014;75:602–607
A new series of 3-(cyclopentyloxy)-4-methoxyphenyl derivatives, structurally related to our hit GEBR-4a (1) and GEBR-7b (2), has been designed by changing length functionality the chain linking catecholic moiety terminal cycloamine portion. Among numerous molecules synthesized, compounds 8, 10a, 10b showed increased potency as PDE4D enzyme inhibitors with respect 2 a good selectivity against PDE4A4, PDE4B2, PDE4C2 enzymes, without both cytotoxic genotoxic effects. The ability enhance cAMP...
Aims Next Generation Sequencing (NGS)-based BRCA tumour tissue testing poses several challenges. As a first step of its implementation within regional health service network, an in-house validation study was compared with published recommendations. Methods Epithelial ovarian cancer (EOC) formalin-fixed paraffin-embedded specimens stored in the archives eight pathology units were selected from consecutive series patients known germline status. Two expert pathologists evaluated cell content...
Epithelial ovarian cancers (EOCs) harboring germline or somatic pathogenic variants in BRCA1 and BRCA2 genes show sensitivity to poly(ADP-ribose) polymerase inhibition. It has been suggested that promoter methylation is perhaps a better determinant of therapy response, because its intrinsic dynamic feature, with respect genomic scars gene mutation. Conflicting evidence was reported so far, the lack validated assay measure considered main confounding factor data interpretation. To contribute...
Endometrial cancer (EC) is the most frequent gynecological cancer. The ESGO/ESTRO/ESP 2020 guidelines identify prognostic groups based on morpho-molecular characteristics. This study aims to evaluate clinical applicability of NGS analysis define an appropriate risk class and improve diagnostic stratification ECs. Cases serous carcinoma (OHEC) high- (HGEC) low-grade (LGEC) endometrioid diagnosed with morphological immunohistochemical (IHC) protocols were considered. After a standardized...
Abstract Cyclic adenosine monophosphate (cAMP) modulates synaptic plasticity and memory manipulation of the cAMP/protein kinase A/cAMP responsive element binding protein pathway significantly affects cognitive functions. Notably, cAMP can increase expression amyloid precursor (APP), whose proteolytic processing gives rise to beta (Aβ) peptides. Despite playing a pathogenic role in Alzheimer's disease, physiological concentrations Aβ are necessary for cAMP‐mediated regulation long‐term...
Endometrial cancer (EC) is the most frequent gynaecological malignancy. The ESGO/ESTRO/ESP 2020 guidelines identify prognostic groups based on morpho-molecular characteristics. This study aims to evaluate clinical applicability of NGS analysis define an appropriate risk class and application for a better diagnostic stratification ECs. Cases serous carcinoma (OHEC), high (HGEC) low (LGEC) grade endometrioid diagnosed with morphological immunohistochemical (IHC) protocols were considered....
Harvester ants often selectively forage seeds, causing these to be viewed as pests in agricultural areas where they may on crop seeds. While little research has been done harvester ant preferences for cover grower observations the Lower Rio Grande Valley (LRGV) suggest that remove seeds before germination. We examined red (Pogonomyrmex barbatus F. Smith) (fescue, oat, sunn hemp, radish, vetch, and wheatgrass) effects of a commonly used bacterial seed inoculant. evaluated relative using...
Cyclic adenosine monophosphate (cAMP) regulates long-term potentiation (LTP) and ameliorates memory in healthy diseased brain. Increasing evidence also shows that, under physiological conditions, low concentrations of amyloid b (A b) are necessary for LTP expression formation. Based on these evidences, we tested the hypothesis a functional correlation between cAMP, A LTP, an attempt to reveal novel molecular mechanisms In neuronal cultured cells rat hippocampal slices, precursor protein...