A5067545135- Wnt/β-catenin signaling in development and cancer
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Nanoparticle-Based Drug Delivery
- Inhalation and Respiratory Drug Delivery
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- interferon and immune responses
University of Science and Technology of China
2020-2023
Abstract Colorectal cancer (CRC) is the second leading cause of mortality worldwide. However, molecular mechanisms underlying CRC progression remain to be further defined improve patient outcomes. In this study, we found that KCTD9, a member potassium channel tetramerization domain-containing ( KCTD ) gene family, was commonly downregulated in tissues and KCTD9 expression negatively correlated with clinical stage. Survival analysis showed patients whose tumors expressed low levels had poorer...
Abstract Interferon (IFN) exerts its effects through interferon-stimulated genes (ISGs), but efficacy is limited by interferon resistance, which can be caused the ubiquitination of key proteins. UBE2O was initially identified as a promising therapeutic target based on data from TCGA and iUUCD 2.0 databases. Through inhibition UBE2O, α/β signaling overall were activated. Integrating proteomic, mass spectrometry, survival analyses led to identification IFIT3, mediator signaling, substrate...