A5028613335- Laser-Plasma Interactions and Diagnostics
- Laser-induced spectroscopy and plasma
- High-pressure geophysics and materials
- Blood Coagulation and Thrombosis Mechanisms
- Laser Design and Applications
- Nuclear Physics and Applications
- Laser Material Processing Techniques
- Plasma Diagnostics and Applications
- Magnetic confinement fusion research
- Laser-Matter Interactions and Applications
- Complement system in diseases
- Blood properties and coagulation
- Lipoproteins and Cardiovascular Health
- Particle accelerators and beam dynamics
- Astro and Planetary Science
- Venous Thromboembolism Diagnosis and Management
- Protease and Inhibitor Mechanisms
- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Solar and Space Plasma Dynamics
- Bone and Joint Diseases
- Renal Diseases and Glomerulopathies
- Solid State Laser Technologies
- Fusion materials and technologies
Ehime Prefectural Central Hospital
2024
Tokai University
2013-2024
Graduate School for the Creation of New Photonics Industries
2014-2023
Osaka University
1982-2022
Fusion Academy
2022
Fusion (United States)
2022
Central Dermatology
2021
Toyota Motor Corporation (Switzerland)
2021
Nagasaki University Hospital
2018-2019
Shiga University of Medical Science
2016
Summary We examined 395 patients with disseminated intravascular coagulation (DIC) divided into two groups: non-leukemic and leukemic. In 58% of the as a whole, treatment DIC resulted in complete or partial remission, while exacerbation death occurred 31%. The efficacy group was less than that leukemic group, indicating outcome depended, part, on underlying disease. hemostatic indicators relation to score: prothrombin time (PT) ratio, FDP, platelet count, fibrinogen levels were found be...
BACKGROUND : Severe deficiency of vWF‐cleaving protease (vWF‐CPase) activity was recently found in patients with thrombotic thrombocytopenic purpura (TTP). Although the survival TTP has been dramatically improved plasma exchange (PE), there are still many who refractory to PE and immunosuppressive therapy. STUDY DESIGN AND METHODS The activities vWF‐CPase its inhibitor were measured 27 nonfamilial hemolytic‐uremic syndrome (HUS) examine relationship between clinical variables activity....
The major cause of death in patients with chronic kidney disease (CKD) is cardiovascular disease. Here, p-Cresyl sulfate (PCS), a uremic toxin, considered to be risk factor for CKD. However, our understanding the vascular toxicity induced by PCS and its mechanism incomplete. purpose this study was determine whether enhances production reactive oxygen species (ROS) endothelial smooth muscle cells, resulting cytotoxicity. exhibited pro-oxidant properties human umbilical vein cells (HUVEC)...
It has been reported that glucose responses during the oral tolerance test differ between healthy women and men. However, it remains unknown what factors contribute to these differences sexes. The present study analyzed insulin glucagon in 25 female 38 male young adults aged 22-30 years. plasma levels at 120 min were significantly higher than Insulin secretion was greater 30, 90 from baseline Glucagon suppression 30 men when determined by a sandwich enzyme-linked immunosorbent assay kit....
Abstract Hypercholesterolemia is associated with an increased incidence of vascular complications. To assess the actual degree activation coagulation systems and disorders in hypercholesterolemia, plasma levels endothelial cell markers, such as thrombomodulin (TM), tissue‐type plasminogen activator, activator inhibitor‐l (PAl‐l), von Willebrand factor, were measured 51 patients hypercholesterolemia. We also investigated effects Pravastatin, inhibitor 3‐hydroxy‐3‐methylglutaryl coenzyme A...
The ability to obtain high plasma densities with fractional ionization using readily available, low-cost components makes the helicon a candidate source for many applications, including rocket propulsion, fusion component testing, and materials processing. However, operation of can be sensitive function magnetic field strength geometry as well driving frequency, especially when light feedstock gases such hydrogen or helium. In this paper, results from coupled rf transport model are compared...
Abstract Early diagnosis is necessary for the treatment of disseminated intravascular coagulation (DIC), but criteria stage preceding DIC (pre‐DIC) have not yet been established. To clarify hemostatic abnormalities that occur before onset DIC, we performed studies in 117 patients within at least a week (pre‐DIC), 237 with and 50 without or pre‐DIC (non‐DIC). Levels FDP, PT, fibrinogen, platelet counts were significantly abnormal after before. Thrombin‐antithrombin III complex (TAT),...
Plasma-soluble fibrin monomer (SFM) level in patients with disseminated intravascular coagulation (DIC) was significantly higher than the pre-DIC or non-DIC patients, and that patients. There no significant difference plasma SFM levels among various diseases underlying DIC. Plasma good outcome decreased after treatment for The sensitivity of degradation products platelet number high DIC, but not pre-DIC. thrombin-antithrombin III complex, plasmin-plasmin inhibitor both DIC specificity these...
Various hemostatic and vascular endothelial cell markers were measured in patients with disseminated intravascular coagulation (DIC), non-DIC, or thrombotic thrombocytopenic purpura (TTP) healthy volunteers to examine the relationships between abnormalities injuries patients' outcomes. Although plasma levels of soluble fibrin monomer, thrombin-antithrombin complex, plasmin-plasmin inhibitor D-dimer significantly increased DIC patients, there no significant differences these who survived...
We measured the plasma level of fibrinogen in 560 patients with disseminated intravascular coagulation (DIC) and evaluated its relationship outcome other hemostatic markers. Forty-seven percent had >200 mg/dL 24% <100 mg/dl fibrinogen, suggesting that is not a sensitive marker for DIC. In our analysis levels, rate death was high leukemia/lymphoma concentration, but no significant difference observed relation to concentration non-leukemia/lymphoma Among leukemia/lymphoma, frequency organ...
A novel direct core heating fusion process is introduced, in which a preimploded predominantly heated by energetic ions driven LFEX, an extremely ultrashort pulse laser. Consequently, we have observed the D(d,n)^{3}He-reacted neutrons (DD beam-fusion neutrons) with yield of 5×10^{8} n/4π sr. Examination verified that directly collide plasma. While hot electrons heat whole volume, deposit their energies locally core, forming spots for fuel ignition. As evidenced spectrum, simultaneously...
A tailored-pulse-imploded core with a diameter of $70\text{ }\text{ }\ensuremath{\mu}\mathrm{m}$ is flashed by counterirradiating 110 fs, 7 TW laser pulses. Photon emission ($>40\text{ }\mathrm{eV}$) from the exceeds imploded 6 times, even though heating pulse energies are only one seventh implosion energy. The coupling efficiency to using counterirradiation 14% enhancement photon emission. Neutrons also produced counterpropagating fast deuterons accelerated pressure collisional...
Abstract The plasma level of tumor necrosis factor (TNF) was determined in 20 normal individuals, 52 patients with disseminated intravascular coagulation (DIC), 22 pre‐DIC patients, and 39 non‐DIC patients. TNF not detected the subjects, very low However, significantly elevated DIC it moderately increased shortly before onset DIC. This increase circulating may be associated higher solid cancer than leukemia or sepsis. mildly correlated score, poor prognosis. organ failure different from...
Summary The plasma level of interleukin-1β (IL-1β) was determined in normal individuals, patients with disseminated intravascular coagulation (DIC), the pre-DIC period (within 7 days before onset DIC), and non-DIC to examine relationship between DIC ILlp level. IL-1β 0-0.085 ng/ml little difference being seen according related age. It significantly higher group (0.19 ± 0.19 ng/ml) than (0.05 0.08 or (0.09 0.01 ng/ml). not markedly elevated leukemia patients, even group, but it increased...
A high density (1019 m−3) hydrogen plasma has been sustained successfully in axially non-uniform static magnetic field configurations for frequencies both above and below the limit of lower hybrid resonance frequency (LH-HD). Wave measurements suggest several modes are coupling to generate these helicon plasmas. The dependence on strength a fixed geometry can be explained by waves, with wavelength close antenna length, that couple fundamental radial mode LH-HD second frequency.
The first report on a model experiment of cosmic ray acceleration by using intense laser pulses is presented. Large amplitude light waves are considered to be excited in the upstream regions relativistic astrophysical shocks and wakefield rays can take place. By substituting an pulse for large waves, such shock environments were modeled laboratory plasma. A plasma tube, which created imploding hollow polystyrene cylinder, was irradiated pulse. Nonthermal electrons generated energy...
Pellet injection and repetitive laser illumination are key technologies for realizing inertial fusion energy. Numerous studies have been conducted on target suppliers, injectors, tracking systems flying pellet engagement. Here we the first time demonstrate injection, counter beams' engagement neutron generation. Deuterated polystyrene (CD) bead pellets, after free-falling a distance of 18 cm at 1 Hz, successfully engaged by two beams from diode-pumped, ultra-intense HAMA. The energy, pulse...
A Ti : sapphire laser HAMA pumped by a diode-pumped solid-state (DPSSL) is developed to enable high-repetitive inertial confinement fusion (ICF) experiment be conducted. To demonstrate counter-irradiation fast-heating scheme, 3.8 J, 0.4 ns amplified chirped pulse divided into four beams: two counter-irradiate target with intensities of 6 × 1013 W cm−2, and the remaining are pulse-compressed 110 fs for heating imploded 2 1017 cm−2. contributed first demonstration showing that 10 J class DPSSL...
The first use of a high-repetition-rate laser-diode (LD)-pumped laser in fusion target experiment is demonstrated. An LD-pumped Nd-solid state laser's output coupled to Ti:sapphire laser, enabling the resulting HAMA generate 2-J, 815-nm-wavelength with pulse width 150 fs and repetition rate 10 Hz. A photon-to-photon efficiency 1.25% (electric-to-photonic 0.7%) achieved, which an order magnitude higher than that current flash-lamp lasers. Irradiation 500-µm-thick deuterated polystyrene film...
Inverse Compton X-rays from laser-accelerated multiple electron bunches are observed. A Ti:sapphire laser (pulse energy: 500 mJ; pulse width: 150 fs) beam is divided into two beams. The main focused onto an edge of a helium gas jet to accelerate electrons energies 14 and 23 MeV, which inversely scattered the head-on colliding secondary 6 12 keV X-rays; this agrees well with that calculated spectra obtained. This demonstrates first on-axis inverse scattering X-ray energy detection beyond 10...
The role of glucagon abnormality has recently been reported in type 2 diabetes; however, its gestational diabetes mellitus (GDM) is still unknown. glucose intolerance GDM heterogeneous, and not all patients require insulin treatment during pregnancy. Here, we investigated whether associated with the requirement for