A5072141801- Blood Coagulation and Thrombosis Mechanisms
- Streptococcal Infections and Treatments
- Complement system in diseases
- Otolaryngology and Infectious Diseases
- Lung Cancer Treatments and Mutations
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Infectious Diseases and Tuberculosis
- T-cell and Retrovirus Studies
- Tracheal and airway disorders
- Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematological disorders and diagnostics
- Infective Endocarditis Diagnosis and Management
- Blood groups and transfusion
- Medical Imaging and Pathology Studies
- Antifungal resistance and susceptibility
- Infectious Diseases and Mycology
- Animal Disease Management and Epidemiology
- Acute Myocardial Infarction Research
- Aerospace Engineering and Energy Systems
- Inflammation biomarkers and pathways
- Lipoproteins and Cardiovascular Health
- Diagnosis and treatment of tuberculosis
Ise Red Cross Hospital
2015-2024
Weatherford College
2023
Nakanishi (Japan)
2023
National Center for Global Health and Medicine
2020
Kyushu Institute of Technology
2010-2012
Yamaguchi Red Cross Hospital
1994-2009
Red Cross Hospital
2003
Mie University
1990-1995
Tokushima University
1992
Plasma thrombomodulin (TM) levels were significantly elevated at disease onset in patients with thrombotic thrombocytopenic purpura (TTP) and disseminated intravascular coagulation (DIC), but was not those essential thrombocythemia idiopathic purpura. However, TTP DIC, TM decreased after they achieved complete remission. In both DIC patients, plasma poor prognosis higher than that good prognosis. Among the level organ failure without, there no differences among various underlying diseases...
Abstract Background Immune checkpoint inhibitors have recently become the standard of care in first‐line treatment extensive‐stage small cell lung cancer. Although immune‐related adverse events been reported to influence prognosis non‐small cancer patients, few studies investigated prognostic value patients. In this study, we evaluated patients who developed after with immune inhibitor‐based chemotherapy for Methods We enrolled 90 received as from September 2019 December 2022 six hospitals...
Abstract Hypercholesterolemia is associated with an increased incidence of vascular complications. To assess the actual degree activation coagulation systems and disorders in hypercholesterolemia, plasma levels endothelial cell markers, such as thrombomodulin (TM), tissue‐type plasminogen activator, activator inhibitor‐l (PAl‐l), von Willebrand factor, were measured 51 patients hypercholesterolemia. We also investigated effects Pravastatin, inhibitor 3‐hydroxy‐3‐methylglutaryl coenzyme A...
Abstract We found that patients with thrombotic thrombocytopenic purpura (TTP) have significantly elevated plasma thrombin antithrombin III complex (TAT) and FDP‐D‐dimer levels, while the plasmin‐α2 plasmin inhibitor (PIC) level was only slightly increased. The tissue‐type plasminogen activator (t‐PA) increased, but it well correlated inhibitor‐1 (PAl‐l) level. These findings suggest hypercoagulable hypofibrinolytic states coexist in these patients, contrast to disseminated intravascular...
Abstract Plasma cytokine levels were examined in 13 patients with thrombotic thrombocytopenic purpura (TTP). Auto‐antibodies, platelet‐associated immunoglobulin G, and platelet aggregating factor detected many of these high‐molecular‐weight bands von Willebrand multimers reduced 9 10 examined. Complete remission (CR) was attained 7 the patients, but 6 died. Tumor necrosis (TNF), Interleukin (IL)‐1β, IL‐6, soluble IL‐2 receptor showed marked increases at onset decreased CR. The prognosis...
Abstract The plasma level of tumor necrosis factor (TNF) was determined in 20 normal individuals, 52 patients with disseminated intravascular coagulation (DIC), 22 pre‐DIC patients, and 39 non‐DIC patients. TNF not detected the subjects, very low However, significantly elevated DIC it moderately increased shortly before onset DIC. This increase circulating may be associated higher solid cancer than leukemia or sepsis. mildly correlated score, poor prognosis. organ failure different from...
We examined hemostatic abnormalities in 23 patients with acute myocardial infarction (AMI), 10 pulmonary embolism (PE), and deep vein thrombosis (DVT). At the onset of AMI, plasma levels tissue-type plasminogen activator (t-PA), PA inhibitor-I (PAI-I), fibrin-D-dimer, thrombin-antithrombin complex (TAT), plasmin-plasmin inhibitor (PPIC) were significantly increased. Both total TFPI free-TFPI AMI higher than those healthy volunteers, PE patients, DVT patients. There was no significant...
Summary The plasma level of interleukin-1β (IL-1β) was determined in normal individuals, patients with disseminated intravascular coagulation (DIC), the pre-DIC period (within 7 days before onset DIC), and non-DIC to examine relationship between DIC ILlp level. IL-1β 0-0.085 ng/ml little difference being seen according related age. It significantly higher group (0.19 ± 0.19 ng/ml) than (0.05 0.08 or (0.09 0.01 ng/ml). not markedly elevated leukemia patients, even group, but it increased...
Plasma interleukin-6 (IL-6) was higher in patients with disseminated intravascular coagulation (DIC) than those without DIC. Levels of IL-1β and TNFα were also significantly IL-6 highest underlying sepsis high advanced solid cancer. some acute promyelocytic leukaemia organ failure this complication. DIC showing a poor response to therapy good response. Incubation caused significant increases tissue factor activity mononuclear cells release plasminogen activator-1 antigen from human umbilical...
Abstract We examined red cell fragmentation syndrome (RCFS) induced by mitomycin C (MMC) (13 patients), thrombotic thrombocytopenic purpura (TTP) (17 and disseminated intravascular coagulation (DIC) (15 patients). Plasma cytokine levels were increased in the TTP DIC patients, but not those whose RCFS was MMC, suggesting that activation of immune system plays an important role pathogenesis due to did MMC. thrombomodulin, tissue type plasminogen activator, activator inhibitor‐I all RCFS,...
Plasma thrombin-antithrombin III complex (TAT), FDP-D-dimer, activated protein C (APC)-protein inhibitor (PCI) complex, and tissue type plasminogen activator (t-PA), PA inhibitor-1 (PAI-I) were significantly increased in patients with acute myocardial infarction (AMI) at onset. These exhibited a hypercoagulable state activation The plasma PCI level onset of AMI was within the normal range, but decreased after percutaneous transluminal coronary angioplasty (PTCA). After PTCA, t-PA,...
A 48-year-old Japanese man treated with oral prednisolone, cyclosporine, and everolimus after renal transplantation presented worsening bilateral leg pain over the previous 3 days.Oral levofloxacin had been prescribed 10 days prior by another practitioner for a high-grade fever.Bilateral Achilles tendon swelling right predominance was observed (Picture A).Ultrasonography demonstrated inflammation of sheath B).The condition improved discontinuing C).Drug-induced tendinitis is commonly...
Abstract Background and Objective The relative effectiveness of initial non‐invasive respiratory strategies for acute failure using continuous positive airway pressure (CPAP) or high‐flow nasal cannula (HFNC) is unclear. Methods We conducted a multicenter, open‐label, parallel‐group randomized controlled trial to compare the efficacy CPAP HFNC on reducing risk meeting prespecified criteria intubation improving clinical outcomes hypoxemic failure. primary endpoint was time taken meet within...
Most cases of cavernosal abscesses result from the progression sexually transmitted diseases (STDs) commonly caused by Neisseria gonorrhoeae; however, without STDs are rare events. Herein, we describe first case report a Lactobacillus paragasseri abscess. A 63-year-old man with diabetes and history foreign object insertion into urethra one year prior presented high-grade fever slight local pain. The patient was diagnosed L. abscess based on computed tomography microbial biochemical...
Adding an immune checkpoint inhibitor to chemotherapy treat extensive-stage small cell lung cancer is effective. However, there are no reports of effective second-line treatment in patients previously treated with and inhibitors as a first-line treatment. Here, we assessed the efficacy safety amrubicin for after combination therapy. The study enrolled 150 cancer. incidence adverse events were compared between without previous One hundred twenty-three eligible. There was difference objective...
As cases of magnesium oxide pill aspiration are rare, the associated airway proinflammatory properties and appropriate analytic strategies remain unclear. An 81-year-old woman presenting with dyspnea was diagnosed aspiration. Computed tomography, a "mixing test" levodopa, content analysis revealed similar density between foreign body her prescribed pill. The patient recovered without complications after removal. Clinicians should be aware tablets as potential bronchial bodies in elderly...
Lung abscess has been considered to be a rare complication of pneumococcal infection, and most cases are reported Streptococcus pneumoniae serotype 3. A 67-year-old man presented with fever was diagnosed have lung caused by S. 6B. The minimal inhibitory concentration (MIC) penicillin for the isolate 1 μg/mL. He treated high-dose intravenous sulbactam/ampicillin as definitive therapy based on susceptibility testing recovered successfully without surgical intervention. 6B can cause abscess.
Chronic pulmonary aspergillosis, which features nodular lesions known as Aspergillus nodules, is a relatively uncommon disorder. We herein report case of slowly progressing chronic multiple aspergillosis in 59-year-old man with rheumatoid arthritis, dyspnea, and fatigue. One nodule was surgically resected. The surgical specimen featured central necrosis located adjacent to respiratory bronchiole artery, without parenchymal invasion. Branching septate hyphae, compatible Aspergillus, were seen...
Massive hemoptysis may originate from injured pulmonary arteries, such as artery pseudoaneurysms (PAPs). A 93-year-old man, diagnosed with pneumonia, was hospitalized; he later developed a lung abscess (controlled intravenous antibiotics). On post-hospitalization day 29, suddenly hemoptysis. Multi-detector computed tomography angiography (MDCTA) showed an enhanced nodule, PAP, inside the abscess. The resolved, without recurrence, following transcatheter arterial embolization (TAE) of PAP and...