Although the mechanism of fentanyl-induced cough is unclear, several lines evidence suggest that allergic mediators, such as histamine, may play a role in production coughs. The aim this study was to explore effects fentanyl on sensitivity inhaled citric acid and histamine release BALF mice.The reflex induced by inhalation acid. Male ICR mice were exposed nebulized solution at concentration 0.1 M under conscious identical conditions using body plethysmograph. number coughs produced per 3-min...

Coronavirus disease 2019 (COVID-19) and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are associated with cardiovascular complications. Here, we report a case of right-sided heart failure caused by constrictive pericarditis that developed after the administration messenger ribonucleic acid (mRNA) vaccine SARS-CoV-2. A 70-year-old woman presented body weight gain, peripheral edema, dyspnea on effort, which over period 1 week second dose vaccine. The jugular...

Background: Previous studies have demonstrated that intrathecal administration of the substance P amino-terminal metabolite 1-7 (SP ) and its C-terminal amidated congener induced antihyperalgesic effects in diabetic mice. In this study, we studied a small synthetic dipeptide related to SP endomorphin-2, i.e. Phe-Phe amide, using tail-flick test von Frey filament non-diabetic Results: Intrathecal treatment with increased latency both This effect amide was significantly greater mice than The...

A 48-year-old Japanese man treated with oral prednisolone, cyclosporine, and everolimus after renal transplantation presented worsening bilateral leg pain over the previous 3 days.Oral levofloxacin had been prescribed 10 days prior by another practitioner for a high-grade fever.Bilateral Achilles tendon swelling right predominance was observed (Picture A).Ultrasonography demonstrated inflammation of sheath B).The condition improved discontinuing C).Drug-induced tendinitis is commonly...

Peripheral neuropathy is the major side effect caused by paclitaxel, a microtubule-binding antineoplastic drug. Paclitaxel-induced peripheral causes long-term negative impact on patient's quality of life. However, mechanism underlying paclitaxel-induced still unknown, and there no established treatment. Ghrelin known to attenuate thermal hyperalgesia mechanical allodynia in chronic constriction injury sciatic nerve, inhibit activation nuclear factor kappa B (NFκB) spinal dorsal horn....

Goal: In the following, we will present a newly developed X-ray calibration phantom and its integration for 2-D/3-D pelvis reconstruction subsequent automatic cup planning. Two different planning strategies were applied evaluated with clinical data. Methods: methods investigated: The first strategy is based on combined statistical atlas. Thereby, part of atlas matched to reconstructed model, resulting in an optimized second analyzes morphology model determine best fitting implant. Results:...

Most cases of cavernosal abscesses result from the progression sexually transmitted diseases (STDs) commonly caused by Neisseria gonorrhoeae; however, without STDs are rare events. Herein, we describe first case report a Lactobacillus paragasseri abscess. A 63-year-old man with diabetes and history foreign object insertion into urethra one year prior presented high-grade fever slight local pain. The patient was diagnosed L. abscess based on computed tomography microbial biochemical...

Massive hemoptysis may originate from injured pulmonary arteries, such as artery pseudoaneurysms (PAPs). A 93-year-old man, diagnosed with pneumonia, was hospitalized; he later developed a lung abscess (controlled intravenous antibiotics). On post-hospitalization day 29, suddenly hemoptysis. Multi-detector computed tomography angiography (MDCTA) showed an enhanced nodule, PAP, inside the abscess. The resolved, without recurrence, following transcatheter arterial embolization (TAE) of PAP and...

Abstract Background Cutibacterium modestum is one of the five species genus . While C. acnes has been reported as an important pathogen in bone and joint infections, clinical characteristics infections remain unclear Moreover, thus far, there no case report regarding infections. Case presentation An 82-year-old man with a history repeated trigger point injections for lumbago at L4 level presented fever exacerbation lumbago. Physical examination indicated knocking pain L4–L5 levels; magnetic...

Abstract The distribution of pustular erythema, characteristic clinical course, and pathological findings can help diagnose acute generalized exanthematous pustulosis. Clinical management should include discontinuation the suspected drug, hydrocortisone administration, careful follow‐up examination.

Most cases of mediastinal abscess occur as a postoperative complication thoracic surgical procedure or following trauma. The most common causative microorganism is Staphylococcus aureus, but it can be rarely caused by unusual microorganisms, such Gemella species. These are relatively difficult-to-identify commensal microorganisms the upper respiratory and gastrointestinal tracts may cause several infections. A 66-year-old man was diagnosed with bergeri molecular detection bacterial genes. He...

Infected aneurysms caused by Listeria monocytogenes are extremely rare. Therefore, there is no standard procedure for their diagnosis and treatment. A 76-year-old Japanese man with diabetes hypertension was diagnosed a left common iliac aneurysm L. monocytogenes, using multidetector computed tomographic angiography rapid diagnostic testing of the positive blood culture. He successfully treated combination ampicillin administration, timely surgical debridement, in-situ Y-graft placement...

Abstract Negative blood culture and pathological findings are helpful to diagnose non‐bacterial thrombotic endocarditis. The treatment strategy, including lifelong anticoagulation or surgery, should be individualized based on patients' underlying diseases.

A previously healthy 50-year-old woman presented to the emergency department with neck pain, odynophagia, and fever. Physical examination revealed range of motion limitations left right, worsened pain. Laboratory investigations showed an elevated WBC count C-reactive protein level. Intravenous contrast-enhanced computed tomography (CT) retropharyngeal fluid collection (Figure 1). radiologist otolaryngologist were consulted for suspected abscess. Antibiotics initiated incisional drainage was...

To confirm the usefulness of zebrafish for evaluating teratogenic potential drug candidates, effect O-ethylhydroxylamine hydrochloride (OHY), which induces mutagenesis by methylation, was evaluated in teratogenicity studies rats and zebrafish. In rat study, OHY-induced cardiovascular malformations such as increased abnormal vascular structures ventricular septal defects. study using zebrafish-injected microspheres green fluorescent protein-expressing Tg (flk1:EGFP), OHY exposure associated...

Ovarian abscesses infected with Salmonella species are a rare clinical occurrence. A 26-year-old woman at 36 weeks gestation presented high fever, left lower abdominal pain, and diarrhea; she was referred to our hospital 5 days after vaginal delivery. She diagnosed ovarian abscess underwent enucleation. According the stool findings, we speculated that species; appropriate antibiotics were administered positive identification of stanley. This case highlights importance treating infections in...