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Daisuke Nijoukubo

ORCID: 0000-0002-6774-8430
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About
Contact & Profiles
A5082908819
Research Areas
  • Zebrafish Biomedical Research Applications
  • Environmental Toxicology and Ecotoxicology
  • Immune Response and Inflammation
  • Liver Disease and Transplantation
  • Birth, Development, and Health
  • Liver Disease Diagnosis and Treatment
  • Nitric Oxide and Endothelin Effects
  • Epigenetics and DNA Methylation
  • Adipose Tissue and Metabolism
  • Toxic Organic Pollutants Impact
  • Congenital heart defects research

Rakuno Gakuen University
 2014-2020

 Involvement of COX2–thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish
OPENALEX - Publications 
Hiroki Teraoka Yuki Okuno Daisuke Nijoukubo Ayumi Yamakoshi Richard E. Peterson and 4 more John J. Stegeman Takio Kitazawa Takeo Hiraga Akira Kubota

10.1016/j.aquatox.2014.04.025 article EN Aquatic Toxicology 2014-05-02
 Protective effect of prostacyclin against pre-cardiac edema caused by 2,3,7,8-tetrachlorodibenzo- p -dioxin and a thromboxane receptor agonist in developing zebrafish
OPENALEX - Publications 
Daisuke Nijoukubo Yasuaki Tanaka Yuki Okuno Guojun Yin Takio Kitazawa and 3 more Richard E. Peterson Akira Kubota Hiroki Teraoka

10.1016/j.chemosphere.2016.04.107 article EN Chemosphere 2016-05-10
 Blood vessels are primary targets for 2,3,7,8-tetrachlorodibenzo-p-dioxin in pre-cardiac edema formation in larval zebrafish
OPENALEX - Publications 
Daisuke Nijoukubo Hikaru Adachi Takio Kitazawa Hiroki Teraoka

10.1016/j.chemosphere.2020.126808 article EN Chemosphere 2020-04-18
 Usefulness of zebrafish in evaluating drug-induced teratogenicity in cardiovascular system
OPENALEX - Publications 
Ryo Watanabe Yuki Nakanishi Daisuke Nijoukubo Hiroki Teraoka H. Ogasawara and 1 more Kazuhiko Mori

To confirm the usefulness of zebrafish for evaluating teratogenic potential drug candidates, effect O-ethylhydroxylamine hydrochloride (OHY), which induces mutagenesis by methylation, was evaluated in teratogenicity studies rats and zebrafish. In rat study, OHY-induced cardiovascular malformations such as increased abnormal vascular structures ventricular septal defects. study using zebrafish-injected microspheres green fluorescent protein-expressing Tg (flk1:EGFP), OHY exposure associated...

10.1080/01480545.2018.1485686 article EN Drug and Chemical Toxicology 2018-07-20
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