A5024009138- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- Cardiovascular and Diving-Related Complications
- Congenital Heart Disease Studies
- Pericarditis and Cardiac Tamponade
- Cardiac tumors and thrombi
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- Phonocardiography and Auscultation Techniques
- Helicobacter pylori-related gastroenterology studies
- Coronary Artery Anomalies
- Pulmonary Hypertension Research and Treatments
- Eosinophilic Disorders and Syndromes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Atrial Fibrillation Management and Outcomes
- Gastrointestinal motility and disorders
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Venous Thromboembolism Diagnosis and Management
- Nicotinic Acetylcholine Receptors Study
Kyoto Prefectural University of Medicine
2016-2025
Matsushita Memorial Hospital
2016-2025
Mitsubishi Corporation (Japan)
2020
Saiseikai Shigaken Hospital
2018
Kyoto first Red Cross hospital
2018
Memorial Hospital of South Bend
2007-2015
Kyoto Prefectural University
2011
Astellas Pharma (Japan)
2011
Jichi Medical University
1995
The possibility that 5-hydroxytryptamine (serotonin; 5-HT) mediates bowel dysfunction caused by stress was evaluated in rats and mice treated with 5-HT or thyrotropin-releasing hormone (TRH) injection subjected to stress. Restraint at room temperature (23 degrees C) significantly increased fecal pellet output without the formation of gastrointestinal mucosal lesions free-feeding rats, diarrhea 90 100% animals within 3 hr food-deprived rats. Oral YM060, ondansetron, granisetron, atropine...
Transthyretin (ATTR) cardiac amyloidosis has attracted clinical attention because of the development practical identification and effective treatment. Since one initial manifestations this condition is ventricular hypertrophy, differential diagnosis includes hypertrophic cardiomyopathy (HCM). Midventricular obstruction (MVO) accompanied by paradoxic jet flow (PJF), which an early diastolic from apex to base left ventricle, been observed almost exclusively in HCM. Here, we report a case ATTR...
Patent ductus arteriosus (PDA) is a congenital anomaly characterized by persistent connection between the descending aorta and pulmonary artery. While patients with PDA typically present continuous murmur, atypical cases, such as those systolic murmurs or no (although exact mechanism remains unclear), pose diagnostic challenges. We report case of 38-year-old woman alcoholic liver cirrhosis, referred for transplantation, in whom ejection murmur prompted further evaluation. Diagnostic imaging...
Two-dimensional speckle tracking helped determine whether the tumor adjacent to left ventricular apex had infiltrated pericardium. The peak strain value remains unaffected, although timing in area is delayed. Consequently, was determined not have
(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4- benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022) is an extremely potent and highly selective gastrin/cholecystokinin (CCK)-B receptor antagonist. We compared the gastrin/CCK-B receptor-blocking properties of this compound with those racemate (mixture YM022 its S-form), enantiomer (S-form), L-365, 260 Cl-988 in vitro vivo. replaced specific binding [125I]CCK-8 to rat brain receptors a stereoselective competitive manner. The Ki...
(R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride (YM060) is a structurally novel, extremely potent, and highly selective serotonin (5HT)3 receptor antagonist. Its 5HT3 blocking properties were compared with those of its enantiomer (S-form), granisetron ondansetron, in the isolated distal colon guinea pig. YM060 competitively antagonized 5HT- 2-methyl-5HT-induced contraction colon, pA2 values 8.71 +/- 0.09 (n = 12) 8.69 0.06 9), respectively. antagonistic...
We evaluated the effect of YM022 [(R)-1-[2,3-dihydro-1-(2'- methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3- (3-methylphenyl)urea], a potent and selective gastrin/cholecystokinin-B receptor antagonist, on gastric acid secretion duodenal lesions in rats. Oral (0.1-10 mumol/kg), famotidine (0.3-30 mumol/kg) omeprazole (3-100 dose-dependently suppressed pylorusligated rats with ED50 values 0.83, 1.63 10.9 mumol/kg, respectively. (1-10 mumol/kg p.o.), p.o.) (10-100 prevented...
YM060 [(R)-5-[(1-methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimida zol e hydrochloride], is structurally independent of other 5-HT3 receptor antagonists. We investigated in vivo blocking activity and compared results with those its enantiomer (S-form), ondansetron (GR38032F), granisetron (BRL43694), ICS205-930 [(3 alpha-tropanyl)-1H-indole-3-carboxylic acid ester], LY277359 [endo-5-chloro-2,3-dihydro-2,2-dimethyl-N-(8-methyl-8-azabicyclo[3.2.1]...
Coronavirus disease 2019 (COVID-19) and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are associated with cardiovascular complications. Here, we report a case of right-sided heart failure caused by constrictive pericarditis that developed after the administration messenger ribonucleic acid (mRNA) vaccine SARS-CoV-2. A 70-year-old woman presented body weight gain, peripheral edema, dyspnea on effort, which over period 1 week second dose vaccine. The jugular...
Patients with hypertrophic cardiomyopathy (HCM) sometimes develop myocardial fibrosis in association adverse cardiovascular events. Electrocardiography (ECG) could provide helpful information on HCM, as coronary artery disease.A total of 60 patients HCM without bundle branch block underwent cardiac magnetic resonance imaging (CMR). The extent or location late gadolinium enhancement (LGE) was examined relation to 12-lead ECG. A notch QRS defined at least 2 consecutive spikes the same polarity...
This study aimed to clarify the relationship between cardiovascular prognosis and left ventricular hypertrophy (LVH) in patients with severe aortic stenosis who underwent transcatheter valve replacement (TAVR) investigate cardiac sympathetic nerve (CSN) function these factors using
Female rats were treated orally for 13 wk with YM022 (300 mumol.kg-1.day-1) and omeprazole (400 or famotidine (900 without YM022. At 2 h after the last dose, markedly inhibited basal pentagastrin-induced acid secretion. Famotidine was less potent than against both secretions. The degree of increase in plasma gastrin level three groups parallel to antisecretory potencies drugs. 14 days cessation treatment, secretory response pentagastrin increased above that control. This hyperresponse lasted...
An atrial septal defect (ASD) may be detected later in life due to its asymptomatic status. We report a case of superior sinus venosus ASD, rare type which bedside physical examination was useful for the diagnosis. A 72-year-old male referred cardiology during treatment cerebral infarction. On examination, right ventricular heave, split-second heart sound with an increased pulmonary component, and systolic ejection murmur region were noted. Transthoracic echocardiography showed artery...
Limited data are available regarding Holter monitoring for cardiovascular events except ventricular tachycardia as a risk marker sudden death in hypertrophic cardiomyopathy (HCM). We aimed to examine findings relation the long-term prognosis patients with HCM.Ambulatory was performed 106 HCM sinus rhythm. All were prospectively followed composite endpoint of death, and hospitalization heart failure or stroke associated atrial fibrillation.Cardiovascular occurred 19 during mean follow-up 10.1...
We evaluated the effects of a potent cholecystokinin (CCK)-B/gastrin receptor antagonist, L-365,260 (3R(+)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin - 3-yl)-N'-( 3-methylphenyl) urea); selective CCK-A devazepide (L-364,718); and cimetidine on gastric acid secretion induced by pentagastrin, histamine bethanechol in anesthetized rats. also pylorus-ligated Intravenous administration L-365,260, L-364,718 dose-dependently reduced pentagastrin (20 nmol/kg/hr), with ED50 values...