A5062180456- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Dementia and Cognitive Impairment Research
- Metabolism, Diabetes, and Cancer
- Frailty in Older Adults
- Immunotherapy and Immune Responses
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Phagocytosis and Immune Regulation
- Respiratory Support and Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Pulmonary Hypertension Research and Treatments
- Diabetes Treatment and Management
- Health and Well-being Studies
- Adipose Tissue and Metabolism
- Ocular Infections and Treatments
- Muscle and Compartmental Disorders
- Abdominal vascular conditions and treatments
- Biliary and Gastrointestinal Fistulas
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Connective tissue disorders research
- Amoebic Infections and Treatments
- Otolaryngology and Infectious Diseases
Kobe University
2016-2025
Hyogo University of Health Sciences
2015-2024
Kobe University Hospital
2010-2016
Yale University
2003-2011
The diagnostic criteria for slowly progressive type 1 diabetes (slowly insulin-dependent mellitus; SPIDDM) have been revised by the Committee on Type Diabetes of Japan Society. All following three must be met 'a definitive diagnosis SPIDDM': (1) presence anti-islet autoantibodies at some point in time during disease course; (2) absence ketosis or ketoacidosis with no requirement insulin treatment to correct hyperglycemia immediately after principle; and (3) gradual decrease secretion over...
OBJECTIVE Components of insulin/IGF-1 receptor–mediated signaling pathways in pancreatic β-cells have been implicated the development diabetes, part through regulation β-cell mass vivo. Studies vitro shown that protein Ras homolog enriched brain (Rheb) plays a key role as positive upstream regulator mammalian target rapamycin complex 1 (mTORC1) pathway integrating inputs from nutrients and growth factors for cell growth. Our objective was to investigate mTORC1 RESEARCH DESIGN AND METHODS We...
Type 1 diabetes (T1D) is an organ-specific autoimmune disease caused by T cell-mediated pancreatic β cell destruction. To evaluate the effects of metformin on immune cells in diabetes, we administered intraperitoneally to two T1D mouse models and analyzed progression. In a cyclophosphamide (CY)-induced model male non-obese diabetic (NOD) mice, intraperitoneal administration significantly prevented diabetes. Treatment with showed decrease activated cells, CD44hiCD62Llo effector memory...
We herein report the case of a 63-year-old man who presented with 3-month history cutaneous nodular lesion his jaw, low grade fever, lethargy and progressive cognitive impairment. He had 30-year multiple sclerosis been treated fingolimod for previous 2 years. Laboratory data revealed CD4 lymphocytopenia tissue culture skin nodule was positive Cryptococcus neoformans. Cerebrospinal fluid serum cryptococcal antigen tests were also we diagnosed him to have disseminated cryptococcosis. This...
Local production of immunosuppressive cytokines will be one the most suitable therapeutic strategies against organ-specific autoimmune diabetes. To establish such a new therapy, we constructed recombinant adenoviral vectors with inserted mIL-12p40 (Ad.IL-12p40) and mIL-10 (Ad.IL-10). Sufficient amounts IL-12p40 IL-10 were secreted by relevant adenovirus-transfected nonobese diabetic (NOD) islets. Shortly after transfection, 400 NOD islets transfected Ad.IL-12p40 or Ad.IL-10 transplanted...
The first genome-wide association study of fulminant type 1 diabetes was performed in Japanese individuals. As previously reported using a candidate gene approach, strong observed with multiple single nucleotide polymorphisms (SNPs) the HLA region, and strongest rs9268853 class II DR region (P = 1.56 × 10−23, odds ratio [OR] 3.18). In addition, rs11170445 CSAD/lnc-ITGB7-1 on chromosome 12q13.13 showed an at significance level 7.58 10−9, OR 1.96). Fine mapping revealed that rs3782151 lowest P...
To investigate the differences in clinical significance and glutamic acid decarboxylase autoantibody (GADA) affinity between RIA (RIA-GADA) ELISA (ELISA-GADA) patients with type 1 diabetes.A total of 415 diabetes were enrolled, including 199 acute-onset diabetes, 168 slowly progressive (SPIDDM), 48 fulminant diabetes. GADA was measured by a competitive binding experiment using unlabeled recombinant human GAD65 protein, diagnostic performance both assays relationship decline fasting C-peptide...
Aims Glutamic acid decarboxylase autoantibodies (GADAb) differentiate slowly progressive insulin-dependent (type 1) diabetes mellitus (SPIDDM) from phenotypic type 2 diabetes, but many GADAb-positive patients with do not progress to insulin-requiring diabetes. To characterize adult-onset who require insulin therapy for >5 years (NIR-SPIDDM), we conducted a nationwide cross-sectional survey in Japan. Methods We collected 82 did (NIR-SPIDDM) and compared them 63 SPIDDM (IR-SPIDDM). Clinical...
A corpus of evidence suggests that T-helper type 1 (Th1)-dependent cellular immunity plays a pivotal role in the pathogenesis autoimmune diabetes. This study was intended to find ways prevent development NOD diabetes using neutralizing anti-interleukin (IL)-12 antibody (C17.8) inhibits Thl cell differentiation. When C17.8 administered from 5 30 weeks age, mice exhibited suppression both insulitis and However, when administration ceased at 15 8 13 recipients showed age. These results suggest...
Apoptosis via Fas/Fas ligand (FasL) interactions has been proposed to be a major T-cell-mediated effector mechanism in autoimmune diabetes. To elucidate the role of Fas/FasL NOD diabetes, effects neutralizing anti-FasL antibody on responses were evaluated. Islet-specific CD8+ and CD4+ T-cells expressed FasL upon activation mediated FasL-dependent cytotoxicity against Fas-expressing target cells vitro, although their islet was not blocked by antibody. Moreover, administration failed inhibit...
Peroxisome proliferators-activated receptor gamma (PPAR gamma) is a nuclear hormone that serves as master regulator of adipocytes-specific genes contributing to adipocytes differentiation, susceptibility obesity, and insulin sensitivity. The substitution proline alanine at codon 12 the PPAR gamma2 gene (Pro12Ala polymorphism) most frequently identified associations with diabetes, other clinical parameters have been reported discussed in several ethnic groups. Among native Javanese ethnicity,...
Abstract BACKGROUND The number of people with dementia is increasing in Japan, and establishing evidence for preventing necessary. METHODS This study was a randomized controlled trial cognitively normal community‐dwelling older adults aged 65 to 85 diabetes and/or hypertension. Participants were randomly assigned 1:1 ratio. intervention group underwent 90 min group‐based weekly physical exercise, cognitive training, nutritional counseling, vascular risk management 18 months. primary endpoint...
Diabet. Med. 29, 88–89 (2012) Abstract Background Fulminant Type 1 diabetes was originally reported as idiopathic diabetes. Involvement of viral infections in the pathogenesis fulminant T1D has been suggested, but development after influenza vaccination not reported. Case Report We report a case with thrombocytopenia following vaccination. A 54‐year‐old man admitted to hospital hyperglycaemia and diabetic ketosis. Seven days before admission, he received seasonal vaccine for prevention...
Pulmonary hypertension and exercise-induced oxygen desaturation (EID) influence acute exacerbation of COPD. Computed tomography (CT)-detected pulmonary artery (PA) enlargement is independently associated with COPD exacerbations. Associations between PA to aorta (PA:A) ratio EID in patients have not been reported. We hypothesized that the PA:A correlated results 6-minute walk test (6MWT) would be useful for predicting risk >1.We retrospectively measured lung function, 6MWT, emphysema area, on...