A5059850153- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Pancreatic and Hepatic Oncology Research
- Hormonal Regulation and Hypertension
- Pancreatitis Pathology and Treatment
- Nutrition and Health in Aging
- Dermatology and Skin Diseases
- Ion channel regulation and function
- T-cell and B-cell Immunology
- Cancer, Hypoxia, and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Thyroid Disorders and Treatments
- Genetic Associations and Epidemiology
- Neuroendocrine Tumor Research Advances
- Hair Growth and Disorders
- Clinical Nutrition and Gastroenterology
- Neuroscience of respiration and sleep
- Molecular Biology Techniques and Applications
Kindai University
2016-2024
Abstract Aims/Introduction Differences in the efficacy and safety of antidiabetic drugs among different ethnic groups are well documented. Metformin is widely used treatment type 2 diabetes Western countries, but high doses metformin have been approved only recently for clinical use Japan. The aim present study was to investigate effects dosage dosing frequency on high‐dose Japanese patients. Materials Methods A total 71 patients with were prospectively studied during hospitalization. Dose...
Abstract The targets for continuous glucose monitoring (CGM)-derived metrics were recently set; however, studies on CGM data over a long period with stable glycemic control are limited. We analyzed 194,279 values obtained from 19 adult Japanese patients type 1 diabetes. during four months analyzed. CGM-related of different durations “within 120, 90, 60, 30, and 7 days” calculated baseline. Time in range (TIR; 70–180 mg/dL), time above (TAR; ≥ 181 average levels, but not below (TBR; ≤ 69...
Abstract Aims/Introduction Patients with a total pancreatectomy and type 1 diabetes are similar in regard to absolute insulin deficiency, but different glucagon, providing unique opportunity study the contribution of glucagon glucose metabolism an insulin‐dependent state. The aim present was investigate homeostasis complete deficiency vivo . Methods A 38 individuals lack endogenous (fasting C‐peptide <0.0066 nmol/L) whose glycemic control optimized pump during hospitalization were...
Abstract Context Glucose tolerance worsens after distal pancreatectomy (DP); however, the long-term incidence and factors affecting interindividual variation in this worsening are unclear. Objective To investigate changes diabetes-related traits before DP to clarify of diabetes its predictors. Methods Among 493 registered patients, 117 underwent DP. these, 56 patients without surgery were included study. endocrine function prospectively assessed using a 75-g oral glucose test preoperatively,...
The rate of glucose metabolism changes drastically after partial pancreatectomy.This work aims to analyze in patients' and endocrine exocrine function before pancreatectomy relative different resection types (Kindai Prospective Study on Metabolism Endocrinology Pancreatectomy: KIP-MEP study).A series 278 consecutive patients with scheduled were enrolled into our prospective study. Of them, 109 individuals without diabetes, who underwent pancreatectomy, investigated. Data compared between...
A flash glucose monitoring (FGM) system has become available. To clarify the relationship between FGM and self-monitoring blood (SMBG) values, we compared two values after simultaneous measurement in Japanese patients with type 1 diabetes, under daily life settings.
Abstract Continuous glucose monitoring (CGM) values obtained from CGM systems using the same sensor but with different internal algorithms (the first- and third-generation FreeStyle Libre (1st-gen-libre 3rd-gen-libre, respectively)) were compared. We used 19,819 paired simultaneously measured of 13 patients diabetes. The average value was significantly higher ( P < 0.0001) time below range (CGM 70 mg/dL) lower 3rd-gen-libre than 1st-gen-libre. There a significant correlation between...
Abstract Context and Objectives Thyrotoxic periodic paralysis (TPP) is an acute complication of thyrotoxicosis that can be lethal. TPP rare in Caucasians but often affects young men East Asian populations. This study aimed to clarify the contribution KCNJ18 susceptibility Participants Methods The comprised 635 participants including 13 Japanese patients with TPP, 208 Graves disease without 414 healthy control subjects from (n = 208), Korean 111), Caucasian populations 95). DNA samples 29 (13...
Several genetic loci related to lean mass have been identified in healthy individuals by genome-wide association studies; however, the contribution of these body composition type 2 diabetes remains be investigated. Here, we aimed clarify determinants with diabetes.A total 176 Japanese outpatients (70 women and 106 men) were studied using a cross-sectional design. Body was measured bioimpedance analysis commercially available device (InBody770). Single-nucleotide polymorphisms IRS1...
ABSTRACT Aims/Introduction In the development of type 1 diabetes, metabolites are significantly altered and might be involved in β‐cell destruction protection. We aimed to identify new metabolic markers diabetes patients. Materials Methods A total 33 participants were recruited for this cross‐sectional observational study: 23 with seven 2 three healthy controls. Those further subdivided into groups: new‐onset, microsecretors complete lack endogenous insulin diabetes. Results Metabolomic...
Abstract Context The glucose tolerance of patients changes considerably from before to after pancreaticoduodenectomy wherein approximately half the pancreas is resected. Objective aim this prospective study was investigate incidence and risk factors for diabetes pancreaticoduodenectomy. Methods This a part an ongoing study, Kindai Prospective Study on Metabolism Endocrinology Pancreatectomy (KIP-MEP) study. Of 457 enrolled date, 96 without who underwent were investigated in Preoperatively, 1...
Characterization of adrenocortical disorders is challenging because varying origins, laterality, the presence or absence hormone production, and unclarity about benign malignant nature lesion. Histopathological examination in conjunction with immunohistochemistry generally considered mandatory this characterization. We report a rare case bilateral adenomas associated unilateral adrenal endothelial cysts 65-year-old woman whose condition was not diagnosed before surgery. Detailed histological...
Abstract Mixed corticomedullary tumors (MCMTs) are rare and comprise medullary cortical cells in a single adrenal tumor. The mechanisms underlying their development have not been fully elucidated. Here, we report case of MCMT 42-year-old woman. Based on the preoperative clinical findings, patient was diagnosed as having pheochromocytoma with subclinical Cushing syndrome. Postoperative pathological diagnosis revealed that tumor demonstrated morphologically distinct components, which produced...
Abstract Adrenocortical carcinoma (ACC) is a rare tumor, and some histological variants (oncocytic, myxoid, sarcomatoid ACCs) have been reported in addition to the conventional ACC. Among these subtypes, oncocytic ACC histologically characterized by presence of abundant eosinophilic granular cytoplasm cells owing accumulation mitochondria, which generally yields high 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET). Herein, we report case 21-year-old woman with low...
We herein report a 52-year-old woman with rare combination of short bowel syndrome due to massive resection the small intestine and complete loss endogenous insulin type 1 diabetes. To provide nutritional support, she was treated total parenteral nutrition co-administration insulin, requiring careful matching glucose levels. This case provides insights on glycemic excursion action in diabetes, even when both are administered directly into circulation, usual obstacles caused by subcutaneous...