A5045989814- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Blood properties and coagulation
- Lipid metabolism and disorders
- Metabolism, Diabetes, and Cancer
- Ion Transport and Channel Regulation
- Regulation of Appetite and Obesity
- Gout, Hyperuricemia, Uric Acid
- Diet and metabolism studies
- Peroxisome Proliferator-Activated Receptors
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Extracellular vesicles in disease
- Diabetes Management and Research
- Biomarkers in Disease Mechanisms
- Diet, Metabolism, and Disease
- Pharmacology and Obesity Treatment
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Alcohol Consumption and Health Effects
- Retinoids in leukemia and cellular processes
Kindai University
2023-2025
Osaka University
2015-2024
Suita Municipal Hospital
2012
Hyogo Medical University
2011
Tokyo Women's Medical University
2011
Daiichi-Sankyo (Japan)
2011
Sheba Medical Center
2006
Wolfson Medical Center
2006
Tel Aviv University
2006
Boston University
2006
Insulin resistance and its dreaded consequence, type 2 diabetes, are major causes of atherosclerosis. Adiponectin is an adipose-specific plasma protein that possesses anti-atherogenic properties, such as the suppression adhesion molecule expression in vascular endothelial cells cytokine production from macrophages. Plasma adiponectin concentrations decreased obese diabetic subjects with insulin resistance. A regimen normalizes or increases might prevent atherosclerosis patients In this...
Background— High-sensitive C-reactive protein (hs-CRP) is a well-known risk factor for coronary artery disease (CAD). Recently, we have demonstrated that adiponectin served as an antiatherogenic plasma which was secreted specifically from adipocytes. The present study investigated the association between and CRP in blood stream adipose tissue. Methods Results— We studied total of 101 male patients, 71 whom had angiographically documented atherosclerosis. As control group, 30 patients with...
Adiponectin, an adipose-specific secretory protein, exhibits antidiabetic and antiatherogenic properties. In the present study, we examined effects of sex hormones on regulation adiponectin production. Plasma concentrations were significantly lower in 442 men (age, 52.6 +/- 11.9 years [mean SD]) than 137 women (53.2 12.0 years) but not different between pre- postmenopausal women. mice, ovariectomy did alter plasma levels. contrast, high levels found castrated mice. Testosterone treatment...
Obesity is more linked to vascular disease, including atherosclerosis and restenotic change, after balloon angioplasty. The precise mechanism linking obesity disease still unclear. Previously we have demonstrated that the plasma levels of adiponectin, an adipose-derived hormone, decreases in obese subjects, hypoadiponectinemia associated ischemic heart disease. In current study, investigated vivo role adiponectin on neointimal thickening artery injury using adiponectin-deficient mice...
Adiponectin is a fat-derived hormone with antidiabetic and antiatherogenic properties. Hypoadiponectinemia seen in obesity associated insulin-resistant diabetes atherosclerosis. Thiazolidinediones, peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists, have been shown to increase plasma adiponectin levels by the transcriptional induction adipose tissues. However, precise mechanism of such action unknown. In this study, we identified functional PPAR-responsive element (PPRE) human...
Endothelial dysfunction is a crucial feature in the evolution of atherosclerosis. Adiponectin an adipocyte-specific plasma protein with antiatherogenic and antidiabetic properties. In present study, we investigated relation between adiponectin endothelium-dependent vasodilation. We analyzed endothelial function 202 hypertensive patients, including those who were not taking any medication. Forearm blood flow was measured by strain-gauge plethysmography. Plasma level highly correlated...
Background— Vascular inflammation and subsequent matrix degradation play an important role in the development of atherosclerosis. We previously reported that adiponectin, adipose-specific plasma protein, accumulated to injured artery attenuated vascular inflammatory response. Clinically, high adiponectin level was associated with low cardiovascular event rate patients chronic renal failure. The present study designed elucidate effects on metalloproteinases (MMPs) tissue inhibitor (TIMPs)...
Patients with obesity are susceptible to hypertension. We have reported that the plasma adiponectin levels decreased in and has many defensive properties against obesity-related diseases, such as type 2 diabetes coronary artery disease. The aim of this study was determine relationship between hypertension mice. measured blood pressure heart rate directly by a catheter carotid indirectly automatic sphygmomanometer at tail artery. Obese KKAy mice had significantly lower higher systolic than...
Obesity is often accompanied by hyperuricemia. However, purine metabolism in various tissues, especially regarding uric acid production, has not been fully elucidated. Here we report, using mouse models, that adipose tissue could produce and secrete through xanthine oxidoreductase (XOR) the production was enhanced obesity. Plasma elevated obese mice attenuated administration of XOR inhibitor febuxostat. Adipose one major organs had abundant expression activities XOR, tissues higher than...
Abstract Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It detectable in the peripheral blood, allowing low-invasive assessment early signs neurodegeneration. The level NfL gradually increases with age; however, what other factors affect it remains unclear. present study examined association between blood and renal function among healthy participants undergoing health check (n = 43, serum NfL) patients diabetes mellitus 188, plasma NfL). All were 60 years...
In adipocytes, hydrolysis of triglycerides results in the release free fatty acids and glycerol. Aquaporin 7 (AQP7), a member aquaglyceroporins, is known to permeabilize glycerol water. We recently generated Aqp7 -knockout (KO) mice demonstrated that such have low plasma levels impaired response β3-adrenergic agonist, suggesting AQP7 acts as gateway molecule adipocytes for efficient vivo . Although there was no difference body weight between WT KO until 10 weeks age, here we found developed...
Plasma glycerol is a major substrate for hepatic gluconeogenesis. Aquaporin adipose (AQPap/7), an adipose-specific channel, provides fat-derived into plasma. In the present study, we cloned coding and promoter regions of mouse aquaporin 9 (AQP9), liver-specific channel. Fasting refeeding mice increased decreased AQP9 mRNA levels, respectively. Insulin deficiency induced by streptozotocin resulted in mRNA. These changes were accompanied those gluconeogenic mRNAs plasma levels. cultured...
AimsIn obesity, chronic low-grade inflammation and overproduction of reactive oxygen species (ROS) in fat contribute to the development metabolic syndrome. Suppression ROS production may attenuate Activation mineralocorticoid receptor (MR) promotes heart, kidney, vasculature via generation. However, significance MR remains elusive. Here we investigated whether blockade attenuates obesity-related insulin resistance improves adipocyte dysfunction.
Obesity is a common risk factor in insulin resistance and cardiovascular diseases. Although hypoadiponectinemia associated with obesity-related metabolic vascular diseases, the role of adiponectin thrombosis remains elusive.We investigated platelet thrombus formation knockout (APN-KO) male mice (8 to 12 weeks old) fed on normal diet. There was no significant difference counts or coagulation parameters between wild-type (WT) APN-KO mice. However, showed an accelerated carotid arterial injury...
Objective— Obesity is recognized increasingly as a major risk factor for kidney disease. We reported previously that plasma adiponectin levels were decreased in obesity, and had defensive properties against type 2 diabetes hypertension. In this study, we investigated the role of disease subtotal nephrectomized mouse model. Methods Results— Subtotal (5/6) nephrectomy was performed adiponectin-knockout (APN-KO) wild-type (WT) mice. The procedure resulted significant accumulation glomeruli...
Objectives— Adiponectin is recognized as an antidiabetic, antiatherosclerotic, and anti-inflammatory protein derived from adipocytes. However, the role of adiponectin in cardiac fibrosis remains uncertain. We herein explore effects on induced by angiotensin II (Ang II). Methods Results— Wild-type (WT), knockout (Adipo-KO), PPAR-α (PPAR-α-KO) mice were infused with Ang at 1.2 mg/kg/d. Severe left ventricular dysfunction observed II–infused Adipo-KO compared to WT mice. Adenovirus-mediated...
Adipocytes hydrolyze triglycerides and secrete free fatty acids glycerol into the circulation. The molecular mechanism involved in transport from adipocytes has not been elucidated. Here, we investigated glucose metabolism mice lacking aquaporin 7 ( Aqp7 ), a member of aquaglyceroporins expressed adipose tissue, demonstrated that functions as gateway molecule vivo. -knockout (KO) had lower plasma levels compared with WT but normal acid levels. increase level response to β 3 -adrenergic...
Adiponectin, an adipocyte-derived circulating protein, accumulates in vasculature, heart, and skeletal muscles through interaction with a unique glycosylphosphatidylinositol-anchored cadherin, T-cadherin. Recent studies have demonstrated that such accumulation is essential for adiponectin-mediated cardiovascular protection. Here, we demonstrate the adiponectin/T-cadherin system enhances exosome biogenesis secretion, leading to decrease of cellular ceramides. Adiponectin accumulated inside...