A5055216214- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Photonic and Optical Devices
- Cardiac pacing and defibrillation studies
- Urinary Bladder and Prostate Research
- Semiconductor Quantum Structures and Devices
- Pelvic floor disorders treatments
- Gyrotron and Vacuum Electronics Research
- Particle accelerators and beam dynamics
- Semiconductor Lasers and Optical Devices
- Nonlinear Optical Materials Research
- Advanced MRI Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Optical Network Technologies
- Medical Imaging Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Congenital Heart Disease Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Urological Disorders and Treatments
- Ion Channels and Receptors
- Cardiovascular Function and Risk Factors
- Photorefractive and Nonlinear Optics
- Hepatocellular Carcinoma Treatment and Prognosis
- Venous Thromboembolism Diagnosis and Management
Shinshu University
1987-2024
Shinshu University Hospital
2019-2023
Mitsubishi Chemical (Japan)
2023
Ōtani University
2020-2022
Toho University
2016-2021
Toho University Ohashi Medical Center
2019-2021
University of Yamanashi
2008-2020
Nagano Municipal Hospital
2019
Nara Medical University
2018
National Hospital Organization
2017
Dysregulation of adipocyte-derived bioactive molecules plays an important role in the development atherosclerosis. We previously reported that adiponectin, adipocyte-specific plasma protein, accumulated injured artery from and suppressed endothelial inflammatory response vascular smooth muscle cell proliferation, as well macrophage-to-foam transformation vitro. The current study investigated whether increased adiponectin could actually reduce atherosclerosis vivo.Apolipoprotein E-deficient...
Background— High-sensitive C-reactive protein (hs-CRP) is a well-known risk factor for coronary artery disease (CAD). Recently, we have demonstrated that adiponectin served as an antiatherogenic plasma which was secreted specifically from adipocytes. The present study investigated the association between and CRP in blood stream adipose tissue. Methods Results— We studied total of 101 male patients, 71 whom had angiographically documented atherosclerosis. As control group, 30 patients with...
Adiponectin is an adipocyte-derived, antiatherogenic protein that present in serum as three isoforms. Total adiponectin levels are decreased obese or diabetic humans animal models. This study was designed to elucidate the relative isoform distribution of human disease states and identify active form toward vascular endothelial cells. The percentage high molecular weight (HMW) per total significantly lower patients with coronary artery than control subjects, whereas hexamer similar trimer...
Endothelial dysfunction is a crucial feature in the evolution of atherosclerosis. Adiponectin an adipocyte-specific plasma protein with antiatherogenic and antidiabetic properties. In present study, we investigated relation between adiponectin endothelium-dependent vasodilation. We analyzed endothelial function 202 hypertensive patients, including those who were not taking any medication. Forearm blood flow was measured by strain-gauge plethysmography. Plasma level highly correlated...
Background— Vascular inflammation and subsequent matrix degradation play an important role in the development of atherosclerosis. We previously reported that adiponectin, adipose-specific plasma protein, accumulated to injured artery attenuated vascular inflammatory response. Clinically, high adiponectin level was associated with low cardiovascular event rate patients chronic renal failure. The present study designed elucidate effects on metalloproteinases (MMPs) tissue inhibitor (TIMPs)...
The clinical application of human induced pluripotent stem cell-derived cardiomyocytes (CMs) for cardiac repair commenced with the epicardial delivery engineered tissue; however, feasibility direct CMs into muscle layer, which has reportedly electrical integration, is unclear because concerns about poor engraftment and posttransplant arrhythmias. Thus, in this study, we prepared purified spheroids (hiPSC-CSs) investigated whether their injection could regenerate infarcted nonhuman primate hearts.
Adiponectin is an antiatherogenic adipokine that inhibits inflammation by mechanisms are not completely understood. We explored the effect of adiponectin on endothelial synthesis interleukin-8 (IL-8), a pro-inflammatory chemokine plays role in atherogenesis. decreased secretion IL-8 from human aortic cells (HAEC) stimulated with tumor necrosis factor-alpha (TNF-alpha). also inhibited mRNA expression induced TNF-alpha. Phosphorylation IkappaB-alpha was adiponectin, but phosphorylation ERK,...
Third-order harmonic generation has been measured on highly oriented polydiacetylene (PDA) films prepared by the vacuum deposition method. Experimental values of third-order electric susceptibility χ(3) for pumping laser polarized parallel to polymer chain show a sharp three-photon resonance 1Bu exciton in PDA. Potential usefulness these PDA evaporated nonlinear optical applications is suggested.
Vascular cells contribute to organogenesis and tumorigenesis by producing unknown factors. Primary endothelial (PECs) provide an instructive platform for identifying factors that support stem cell tumor homeostasis. However, long-term maintenance of PECs requires stimulation with cytokines serum, resulting in loss their angiogenic properties. To circumvent this hurdle, we have discovered the adenoviral E4ORF1 gene product maintains survival facilitates organ-specific purification PECs, while...
Recombination radiation below the lowest confined particle transition energy observed in GaAs/AlGaAs multi-quantum-well heterostructure lasers was studied comparison with that conventional GaAs double-heterostructure lasers. The spontaneous emission shows lower-energy-side broadening proportion to 1/2.6 power of injected carrier density for both MQW structures and DHs. This dependence suggests low-energy-side is due carrier-induced energy-gap shrinkage. gap shrinkage considered theoretically...
Abstract Third-order optical nonlinearities have been evaluated for organic materials in powder, solution, and film forms, by third-harmonic generation (THG) measurement. Considerations of the effects THG interference between sample substrate, effect air, are made an accurate x(3) evaluation. Several types monomeric polymeric examined this method.
A gyrotron with an axis-encircling electron beam is capable of high-frequency operation, because the high-beam efficiency kept even at high harmonics cyclotron frequency. We have designed and constructed such a permanent magnet. The has already operated successfully third, fourth, fifth harmonics. frequencies are 89.3, 112.7, 138 GHz, respectively, corresponding cavity modes TE/sub 311/, 411/, 511/. magnet system quite novel consists many elements made NbFeB additional coils for controlling...
The polarisation-dependent gain spectra were measured for multi-quantum-well laser diodes. Differences in the gain-current relationship and peak wavelength between TE TM polarisations are explained by a newly developed model.
To investigate the expressions and sex differences of acid-sensitive ion channels (i.e. ASIC transient receptor potential channel V1, TRPV1; both key receptors for extracellular protons that might underlie acid-evoked pain perception) other nociceptive in mouse bladder.Mucosa muscle layers urinary bladder were separately taken from male female mice. The gene subunits, TRPV1, TRPA1 TRPM8 quantified using real-time reverse transcriptase-polymerase chain reaction. localization protein was...
Abstract Accumulating evidence suggests that human pluripotent stem cell-derived cardiomyocytes can affect “heart regeneration”, replacing injured cardiac scar tissue with concomitant electrical integration. However, electrically coupled graft were found to innately induce transient post-transplant ventricular tachycardia in recent large animal model transplantation studies. We hypothesised these phenomena derived from alterations the grafted cardiomyocyte characteristics. In vitro...
Third-order nonlinear optical properties of As2S3 chalcogenide bulk glass are studied experimentally. Third-harmonic generation (THG) measurement shows the value third-order susceptibility χ(3) to be 5.6×10−19 m2/V2 (1.0×10−11 esu) at funda- mental-light wavelength 2.1 μm. This is more than 300 times that for a silica glass. The dependence THG on has been measured, which indicates enhancement effect due three-photon resonance. Optical Kerr shutter operation also achieved using refractive...
In order to assess the usefulness of Gd-DTPA in evaluation myocardial infarction, 17 patients were examined with gated MR imaging. Scans made by using a spin-echo pulse sequence before and after IV administration 0.15 mmol/kg Gd-DTPA. The images at four intervals (average 5, 12, 30, 90 days) onset infarction. uptake infarcted area was graded as marked, moderate, or no increase signal intensity visual inspection. At these time intervals, an increased myocardium detected on T1-weighted 14...
Optical absorption spectra of MBE grown GaAs–AlAs superlattices with various thickness the potential-well layer were measured in temperature range up to 500 K. The excitonic peak is observed even at a K or higher. broadening parameter \varGamma for exciton was determined by curve fitting. This determines limit below which double peaks due heavy and light hole are observed.
Third-harmonic generation measurements have been made on poly(2,5-thienylene vinylene) (PTV) thin films. The third-order optical susceptibility χ(3) was evaluated to be 3.2×10−11 esu at 1.85 μm wavelength. It also revealed that in weakly iodine-doped PTV films, almost the same value as of nondoped a shorter wavelength region expected much higher than obtained this work due resonant effect.
Spontaneous and stimulated emission spectrum the different characteristics between TE TM polarizations were investigated on a GaAs–AlGaAs multi-quantum-well (MQW) laser diode grown by molecular beam epitaxy. The MQW lases at 38 meV below photoluminescence peak energy corresponding to lowest confined electron heavy hole recombination E1h, calculated using Kronig–Penney model. However, this separation cannot be interpreted in terms of LO-phonon assisted which is usually accepted. model can...