A5021892524- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Blood Pressure and Hypertension Studies
- Gastrointestinal disorders and treatments
- Receptor Mechanisms and Signaling
- Amphibian and Reptile Biology
- Adipose Tissue and Metabolism
- Insect and Pesticide Research
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Genetic diversity and population structure
- Insect-Plant Interactions and Control
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Insect Utilization and Effects
- Plant and animal studies
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Health and Disease Prevention
- Pancreatic and Hepatic Oncology Research
Kyoto University
2019-2025
Broad Institute
2025
Foundation Center
2025
Novo Nordisk (United States)
2025
Allen Institute
2025
Massachusetts Institute of Technology
2025
Oita University
2015-2023
Futaba clinic
2023
Fukuda Denshi (Japan)
2023
Saiseikai Wakakusa Hospital
2018
Epigenetic reprogramming resets parental epigenetic memories and differentiates primordial germ cells (PGCs) into mitotic pro-spermatogonia or oogonia. This process ensures sexually dimorphic cell development for totipotency
Endothelial function is known to be impaired in essential hypertensive patients. In this study, we examined whether antihypertensive drugs improve forearm vasodilatory response reactive hyperemia 26 patients with hypertension (62 +/- 2 years) without diabetes mellitus, hyperlipidemia, coronary heart disease, or cerebrovascular disease. Antihypertensive were never given discontinued for at least 4 weeks before the study. Patients treated monotherapy of either temocapril (2 mg, n = 15)...
Angiotensin II (Ang II) has been shown to induce proliferation of cardiac myocytes. To examine the role Ang in left ventricular (LV) hypertrophy, isoproterenol was infused subcutaneously into 9-week-old male Wistar rats at 4.2 mg/kg/day for 7 days. Infusion increased LV weight and concentrations plasma tissue. In anephric rats, tissue were similarly, but not changed by isoproterenol. Concomitant oral administration trandolapril prevented increases both weight. Treatment with hydralazine...
To examine the role of tissue renin–angiotensin system in left ventricular hypertrophy, converting enzyme inhibitors were administered orally to 12-week-old male spontaneously hypertensive rats (SHR) for 4 weeks, and cardiac angiotensin II was measured. Treatment with enalapril (10mg/kg per day) trandolapril (1 mg/kg lowered systolic blood pressure, weight content. Plasma concentration increased by treatment whereas did not cause any change. There significantly positive correlation between...
Abstract Game theoretical models predict that when one parent reduces its care, the mate should adjust care facultatively to compensate partially. To test these models, mate‐removal and mate‐handicapping techniques have been used. However, there few experimental studies comparing results from removal handicapping, has no study on insects employing handicapping. Male female burying beetles both maintain nest regurgitate young. We examined how beetle parents their level of mates are removed or...
Cohesin, transcription factors (TFs), and mediator complex components regulate gene expression partly by regulating enhancer-promoter (E-P) communication. A new study combined E-P distance-controlled reporter screens with the inhibition or degradation of regulatory proteins uncovered a distance-dependent effect across cohesin, TFs, components.
Recent studies suggest the linkage of hypertension and insulin resistance. High fructose diet is known to induce hyperinsulinemia in rats. In a previous study, however, high (66%) failed elevate blood pressure but increased left ventricular weight Sprague-Dawley present we investigated precise mechanism diet-induced changes cardiovascular system Intake fructose-enriched for 2 weeks serum plasma angiotensin II levels. Urinary excretion sodium norepinephrine was not changed. Blood measured...
Abstract To investigate the pathophysiology of cardiac free wall rupture (cardiac rupture) following acute myocardial infarction (AMI), and to clarify whether reperfusion therapy prevents rupture, 1,329 cases AMI (conventional group: 807 533 cases) were studied retrospectively. The overall incidence was 2.3% (2.7% in conventional group vs. 1.7% group). Patients with divided into two subgroups according time interval from onset (early ≤72 h late ≥4 days). indices initial evolution a...
To study the effects of age and hypertension on autonomic nervous function with passive postural change, we examined 31 normotensive subjects (25 to 85 years old) hypertensive patients (21 71 without any cardiac disease, diabetes mellitus, or neurological disorders. Subjects were passively placed in a 60 degrees head-up tilting position after 15 minutes supine position. Autonomic was evaluated by frequency domain analysis heart rate autoregressive method. Using low-frequency (0.1 Hz)...
We examine the phylogenetic structure and morphological differentiation within Hynobius kimurae-H. boulengeri species complex-a widely-distributed group of stream-breeding hynobiid salamanders, inhabiting montane areas western, central eastern parts Honshu Island, Japan. Phylogenetic relationships were assessed based on analyses mitochondrial (mtDNA) nuclear (nuDNA) gene fragments for a total 51 samples representing 23 localities covering entire range complex. Morphological study included...
Hyperinsulinemia or insulin resistance is suggested to play a role in the pathogenesis of hypertension and its target organ diseases. We designed this study evaluate cardiac function, hypertrophy, wall thickness common carotid artery, endothelial function brachial artery essential hypertensive patients without diabetes mellitus. Insulin was evaluated by constant glucose infusion rate (M value) during euglycemic-hyperinsulinemic clamp test. In correlation analysis for several indices...
Molecular cloning of cytochrome P450(11 beta) cDNAs from the adrenal glands Dahl's salt-sensitive hypertensive (DS) and salt-resistant normotensive (DR) rats was performed using a combined technique first strand cDNA synthesis by reverse transcriptase followed polymerase chain reaction. The sequence beta)-DS identical to that wild type beta). In contrast, clone obtained DR rat contained six nucleotide substitutions causing five amino acid alterations (Arg-127-->Cys, Val-351-->Ala,...