A5025177611- Nutrition and Health in Aging
- Breast Cancer Treatment Studies
- Dialysis and Renal Disease Management
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Diet and metabolism studies
- Nutritional Studies and Diet
- Eicosanoids and Hypertension Pharmacology
- Body Composition Measurement Techniques
- GDF15 and Related Biomarkers
- Adipose Tissue and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Fatty Acid Research and Health
- Reconstructive Surgery and Microvascular Techniques
- MicroRNA in disease regulation
- Chronic Kidney Disease and Diabetes
- Mesenchymal stem cell research
- Multiple and Secondary Primary Cancers
- Body Contouring and Surgery
- Clinical Nutrition and Gastroenterology
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Muscle and Compartmental Disorders
- Muscle Physiology and Disorders
- Cancer and Skin Lesions
Sapienza University of Rome
2015-2024
University of Perugia
2022
Policlinico Umberto I
2006-2016
In 2010, the definition of cachexia was jointly developed by European Society for Clinical Nutrition and Metabolism (ESPEN) Special Interest Groups (SIG) "Cachexia-anorexia in chronic wasting diseases" "Nutrition geriatrics". Cachexia considered as a synonym disease-related malnutrition (DRM) with inflammation ESPEN guidelines on definitions terminology clinical nutrition. Starting from these concepts taking into account available evidence SIG conducted several meetings throughout 2020-2022...
The pathophysiology of cancer anorexia is complex and serum biomarkers, including growth differentiation factor(s) (GDF), may be modulated. We explored the association(s) between GDF-15 levels and, secondarily, with low muscle mass body weight loss in patients. considered gastrointestinal lung patients (CP) healthy BMI-matched controls. FAACT-questionnaire was administered to diagnose we calculated L3-SMI by CT scan assess muscularity, setting their cutoff values at lowest tertile. were...
Abstract Background Adipose tissue metabolism may be impaired in patients with cancer. In particular, increased lipolysis was described cancer-promoting adipose atrophy. For this reason, we assessed the expression of lipolysis-associated genes and proteins subcutaneous (SAT) gastrointestinal (GI) cancer compared to controls verify their involvement cancer, among different types GI cancers, cachexia. Methods We considered (gastric, pancreatic, colorectal) at first diagnosis, with/without...
Small non-coding (snc)RNAs, including microRNAs and P-element induced wimpy testis (PIWI)-interacting-RNAs (piRNAs), crucially regulate gene expression in both physiological pathological conditions. In particular, some muscle-specific (myomiRs) have been involved the pathogenesis of cancer-induced muscle wasting. The aims present study were (i) to profile sncRNAs skeletal plasma gastrointestinal cancer patients (ii) investigate association among differentially expressed level muscularity at...
A relationship between dysbiotic gut microbiome and chronic kidney disease (CKD) has been recently documented; it contributes to CKD-related complications, including cardiovascular disease. Aim: We tested how a low-protein diet (LPD)-with or without oral inulin supplementation as prebiotic-modulates some inflammatory, atherosclerosis endothelial dysfunction indices nutritional markers, well psychocognitive functions in CKD patients. conducted prospective, case-control study on patients...
We assessed the molecular phenotype of browning white adipose tissue in newly diagnosed cancer patients and controls undergoing surgery for gastrointestinal tumors non-malignant diseases, respectively. collected subcutaneous (SAT) samples using RT-PCR, we analyzed expression markers Western blot protein levels UCP1 PGC1α. The Ucp1 mRNA were lower vs. (p = 0.01), whereas Cidea Tmem26 higher patients. found PGC1α controls, while no differences seen UCP1. was cachectic non-cachectic controls....
Adipose tissue (AT) wasting in cancer is an early catabolic event with negative impact on outcomes. Circulating miRNAs may promote body weight loss and cachexia. We measured circulating linked to AT alterations compared their levels between i) gastrointestinal (GI) patients controls, ii) cachectic non-cachectic patients, iii) according adiposity level its distribution.