A5027966081- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Vitamin D Research Studies
- Bone health and treatments
- Magnesium in Health and Disease
- Vitamin K Research Studies
- Pharmacological Effects and Toxicity Studies
- Medical Imaging and Pathology Studies
- Cardiovascular Function and Risk Factors
- Potassium and Related Disorders
- Electrolyte and hormonal disorders
- Heart Failure Treatment and Management
- Bone health and osteoporosis research
- Bone and Joint Diseases
- Cardiac Valve Diseases and Treatments
- Fibroblast Growth Factor Research
- Erythropoietin and Anemia Treatment
- Pancreatitis Pathology and Treatment
- Biomedical Research and Pathophysiology
- Chronic Kidney Disease and Diabetes
- Iron Metabolism and Disorders
- Trace Elements in Health
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatological and Skeletal Disorders
- Atrial Fibrillation Management and Outcomes
Klinikum Rheine
2018-2024
Sana Klinikum
2021-2023
Universitätsklinikum Aachen
2011-2022
RWTH Aachen University
2011-2020
RELX Group (United States)
2017-2020
International Society of Nephrology
2020
Klinikum Ludwigsburg
2020
Cedars-Sinai Medical Center
2018
Massachusetts General Hospital
2018
Maastricht University Medical Centre
2007-2017
AimsDialysis patients experience an excess mortality, predominantly of sudden cardiac death (SCD). Accumulating evidence suggests a role vitamin D for myocardial and overall health. This study investigated the impact status on cardiovascular outcomes fatal infections in haemodialysis patients.
The mechanisms for vascular calcification and its associated cardiovascular mortality in patients with ESRD are not completely understood. Dialysis exhibit profound vitamin K deficiency, which may impair carboxylation of the inhibitor matrix gla protein (MGP). Here, we tested whether distinct circulating inactive K–dependent proteins associate all-cause or mortality. We observed higher levels both desphospho-uncarboxylated MGP (dp-ucMGP) desphospho-carboxylated (dp-cMGP) among 188...
Cardiovascular calcification is both a risk factor and contributor to morbidity mortality. Patients with chronic kidney disease (and/or diabetes) exhibit accelerated of the intima, media, heart valves likely myocardium as well rare condition calcific uraemic arteriolopathy (calciphylaxis). Pathomechanistically, an imbalance promoters (e.g. calcium phosphate) inhibitors fetuin-A matrix Gla protein) central in development calcification. Next biochemical proteinacous alterations, cellular...
Fetuin-A is a multifunctional hepatic secretory protein that inhibits the action of insulin in experimental animals. We evaluated association between human serum fetuin-A and metabolic syndrome (MetS) cohort persons with coronary artery disease.We defined MetS by National Cholesterol Education Program criteria among 711 nondiabetic outpatients disease. The mean age was 67 years, 82% were male. divided participants into quartiles concentrations. A total 45% (80 177) highest quartile had...
<i>Objective:</i> Matrix γ-carboxyglutamate (Gla) protein (MGP) is a vitamin K-dependent and strong inhibitor of vascular calcification. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites arterial We hypothesized that as result ucMGP deposition around calcification, the circulating fraction decreased. Here we report on development an assay potential diagnostic utility monitoring serum levels. <i>Methods Results:</i> An...
Accelerated intimal and medial calcification sclerosis accompany the increased cardiovascular mortality of dialysis patients, but pathomechanisms initiating microcalcifications media are largely unknown. In this study, we systematically investigated ultrastructural properties calcifications from patients with uremia. We collected iliac artery segments 30 before kidney transplantation studied them by radiography, microcomputed tomography, light microscopy, transmission electron microscopy...
Background. Calcific uraemic arteriolopathy (CUA, calciphylaxis) is a rare disease predominantly in dialysis patients and associated with high mortality. Painful skin ulcerations calcification of cutaneous arterioles characterize calciphylaxis. Methods. We established an observational, Internet-based registry allowing online notification for all German CUA cases. The recorded data about patient characteristics, biochemistry therapies. Blood samples were stored central biobank. Results....
Background— Fetuin-A is a multifunctional hepatic secretory protein that inhibits dystrophic vascular and valvular calcification. Lower serum fetuin-A concentrations are associated with calcification in persons end-stage renal disease. Whether other patient populations unknown. Methods Results— We evaluated the associations among concentrations, mitral annular calcification, aortic stenosis 970 ambulatory coronary heart disease without severe kidney The presence or absence of was determined...
Sclerostin is a Wnt pathway antagonist regulating osteoblast activity and bone turnover. Here, we assessed the potential association of sclerostin with development coronary artery (CAC) aortic valve calcifications (AVC) in haemodialysis (HD) patients.We conducted cross-sectional multi-slice computed tomography (MS-CT) scanning study 67 chronic HD patients (59.4 ± 14.8 yrs) for measurement CAC AVC. We tested established biomarkers as well serum (ELISA) regarding their to presence...
Background. Previous studies have shown that simple imaging methods may be useful for detection of vascular calcifications in dialysis patients. Based on annual, plain chest X-rays during follow-up dialysis, we studied the associations mineral metabolism with presence and progression aortic calcification. In addition, assessed impact calcification mortality. Methods. Three hundred eighty-four patients who started haemodialysis or peritoneal between 1997 2007 were included (age 61 ± 15 years,...
Derangements in bone metabolism and vascular calcification (VC) substantially contribute to the accelerated cardiovascular morbidity mortality chronic kidney disease (CKD). The Wnt signalling pathway is increasingly recognized play an important role homeostasis VC. Circulating levels of inhibitor sclerostin are elevated CKD patients. present study investigated whether circulating associated with all-cause haemodialysis (HD) patients.We performed a post-hoc survival analysis 100 prevalent HD...
Cardiovascular mortality is high in ESRD, partly driven by sudden cardiac death and recurrent heart failure due to uremic cardiomyopathy. We investigated whether speckle-tracking echocardiography superior routine early detection of cardiomyopathy animal models it predicts cardiovascular patients undergoing dialysis. Using two rat soon (4–6 weeks) after induction kidney disease, we observed that global radial circumferential strain parameters decreased significantly both compared with...
The concept of chronic kidney disease-mineral bone disorder (CKD-MBD) does not appear to fulfil the requirements for a syndrome at first glance, but its definition has brought some clear-cut benefits clinicians and patients, including wider more complex diagnostic therapeutic approaches management this challenging set issues. Admittedly, all components CKD-MBD are present in patients times, these highly interrelated, involving mineral laboratory abnormalities, clinical histological disease...
Vascular calcification is an independent risk factor for cardiovascular disease. Once thought to be a passive process, vascular now known actively prevented by proteins acting systemically (fetuin-A) or locally (matrix Gla protein). Warfarin vitamin K antagonist, widely prescribed reduce coagulation inhibiting K-dependent factors. Recently, it became clear that antagonists also affect inactivation of matrix protein. Here, we investigated functional characteristics in mouse model with...