A5006333132- Systemic Lupus Erythematosus Research
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Blood Coagulation and Thrombosis Mechanisms
- Renal Diseases and Glomerulopathies
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Reproductive System and Pregnancy
- Platelet Disorders and Treatments
- Pregnancy and Medication Impact
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy-related medical research
- Cancer Risks and Factors
- Bariatric Surgery and Outcomes
- Blood disorders and treatments
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Liver Diseases and Immunity
- Preterm Birth and Chorioamnionitis
- Parvovirus B19 Infection Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Celiac Disease Research and Management
- Diabetes and associated disorders
- Uterine Myomas and Treatments
- Adolescent and Pediatric Healthcare
Università Cattolica del Sacro Cuore
2015-2025
Agostino Gemelli University Polyclinic
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Universitat de Barcelona
2021
Sorbonne Université
2021
Althaia
2021
Assistance Publique – Hôpitaux de Paris
2021
Royal Brompton Hospital
2021
University of the Sacred Heart
2018-2019
Catholic University of America
2012-2019
Rheumatic diseases in women of childbearing years may necessitate drug treatment during a pregnancy, to control maternal disease activity and ensure successful pregnancy outcome. This survey is based on consensus workshop international experts discussing effects anti-inflammatory, immunosuppressive biological drugs lactation. In addition, these male female fertility possible long-term infants exposed antenatally are discussed where data were available. Recommendations for lactation given.
Objective To investigate the in vitro ability of antiphospholipid antibodies (aPL) to bind human trophoblast cells and affect gonadotropin secretion invasiveness. Methods Antiphospholipid antibody IgG from women with recurrent miscarriages, β2-glycoprotein I (β2GPI)–independent aPL monoclonal (mAb)(519), IgM anti-β2GPI mAb (TM1G2) were investigated for their binding trophoblasts cultured various amounts time, invasiveness Matrigel-coated filters, release chorionic (hCG). Results Polyclonal...
Objective. To identify the risk factors associated with pregnancy failure in patients APS treated conventional therapy. Methods. A multicentre, case–control study was conducted to compare successful and unsuccessful outcomes. We retrospectively considered 410 pregnancies of women diagnosed primary APS. The focused on 57 (considered population) control matched for age All had been protocol treatments including low-dose aspirin and/or heparin. clinical laboratory features two groups were...
To compare clinical features, laboratory data and fetal-maternal outcomes between 1000 women with obstetric APS (OAPS) 640 aPL-related complications not fulfilling Sydney criteria (non-criteria OAPS, NC-OAPS).This was a retrospective prospective multicentre study from the European Registry on Obstetric Antiphospholipid Syndrome.A total of 1650 5251 episodes, 3601 which were historical latest included. Altogether, cases (OAPS group) fulfilled classification 650 (NC-OAPS did not. Ten NC-OAPS...
This study aimed to describe the long-term outcome and immunological status of children born mothers with antiphospholipid syndrome, determine factors responsible for childhood abnormalities, correlate child's profile their mothers.A prospective follow-up a European multicentre cohort was conducted. The consisted clinical examination, growth data, neurodevelopmental milestones antibodies (APL) screening. Children were examined at 3, 9, 24 months 5 years.134 analysed (female sex in 65 cases,...
Introduction: In this prospective multicenter study, we aimed to describe (1) the outcome of pregnancy in case previous chronic histiocytic intervillositis (CHI), (2) immunological findings and associated diseases, (3) treatments, (4) factors with loss.We prospectively included all patients a prior CHI ongoing between 2011 2013.Twenty-four women (age 34±5 years) were study. An autoimmune disease was present seven (29%) cases. Twenty-one pregnancies treated. The number live births more...
The present study was designed to investigate the effects of immunoglobulin G obtained from patients with antiphospholipid syndrome (APS) on in-vitro models trophoblast invasiveness and differentiation. We tested binding affinity-purified human primary cells. These antibodies affected differentiation cytotrophoblast cells after cell surface. In addition, we determined whether drugs used treat APS might be able restore functions. Low-molecular weight heparin, in a dose-dependent manner,...
The focus of this paper is a case study woman in the first trimester pregnancy who presented with metastatic breast cancer. bony spread metastases was rapid and it necessary to treat patient as soon possible after period organogenesis (days 18-60 human gestation). This stage phase greatest sensitivity teratogens malformations are observed most often. Yet, choice third-line chemotherapy difficult because anthracycline-resistant world literature reported cytotoxic combinated regimens standard...
To evaluate whether abnormal endothelial function, a common finding in premenopausal women with type 2 diabetes, is present early states of diabetes during pregnancy, such as impaired glucose tolerance (IGT) and gestational mellitus (GDM).Brachial artery flow-mediated dilatation (FMD) (endothelium-dependent) nitrate-induced (NID) (endothelium-independent) were measured 23 pregnant subjects carbohydrate abnormalities (10 IGT, 13 GDM) 15 control the third trimester gestation. High-resolution...
To determine whether myomectomy during pregnancy in selected patients improves outcome.Retrospective analysis of 18 who underwent between the 6th and 24th week gestational age. Surgical management tumors was required on basis characteristics myomas symptoms. The dimensions site myomas, symptoms patients, time mode delivery, outcome were analyzed.One woman lost to follow-up, one suffered a miscarriage. remaining 16 delivered healthy babies 36th 41st week; 14 by cesarean section, 2...
Objective: To investigate the predictive value of serum C3 and C4 complement component levels in relation to pregnancy outcome patients with antiphospholipid syndrome (APS). Materials methods: A prospective study 47 pregnancies associated APS was performed. Pregnancy analyzed terms of: fetal loss, preterm delivery (≤34 gestational weeks), intrauterine growth restriction (IUGR), birth weight <2500 g preeclampsia. Week at delivery, neonatal percentile were also investigated....
This study was conducted to determine whether drugs used for conventional treatments of pregnant women with antiphosholipid syndrome might be able restore the gonadotrophin-releasing hormone (GnRH)-induced secretion placental human chorionic gonadotrophin (HCG) in vitro. We tested this hypothesis using a modified enzyme-linked immunosorbent assay (ELISA) and an in-vitro culture system. Pharmacological dose low molecular weight heparin (20 IU/ml) significantly (P < 0.02) reduced...