A5046785461- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Occupational and environmental lung diseases
- Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Cystic Fibrosis Research Advances
- Gallbladder and Bile Duct Disorders
- COVID-19 and healthcare impacts
- Infectious Diseases and Mycology
- Helicobacter pylori-related gastroenterology studies
- Sarcoidosis and Beryllium Toxicity Research
- Hydrogen's biological and therapeutic effects
- Congenital Diaphragmatic Hernia Studies
- Venous Thromboembolism Diagnosis and Management
- Neonatal Respiratory Health Research
- Intestinal and Peritoneal Adhesions
- COVID-19 Clinical Research Studies
- Clinical Nutrition and Gastroenterology
- Tracheal and airway disorders
- SARS-CoV-2 and COVID-19 Research
- Ultrasound in Clinical Applications
- Infections and bacterial resistance
University of Pavia
2020-2025
Policlinico San Matteo Fondazione
2020-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2025
Presidio Ospedaliero
1989
The role of immunosuppression in SARS-CoV-2-related disease (COVID-19) is a matter debate. We here describe the course and outcome COVID-19 cohort patients undergoing treatment with calcineurin inhibitors. In this monocentric study, data were collected from outbreak Italy up to April 28th 2020. Patients followed at our hospital for solid organ transplantation or systemic rheumatic disorders (RMDs) on inhibitor (CNI)-based therapy. Selected referred North Italy. aim study was evaluate...
Ozone therapy can display a wide range of clinical beneficial effects, including antimicrobial, immune-stimulant, analgesic, anti-hypoxic actions. However, there is still paucity data regarding the ozone fungicide activity. Oral Candida most common fungal infection in mouth among denture wearers and people with weakened immune systems. In case generalized candidiasis or immunocompromised patients, systemic needed, while localized infections are treated topic medications. many strains...
Background: Chronic obstructive pulmonary disease (COPD) is among the most relevant comorbidity associated with lung cancer. The advent of innovative triple treatment approaches for COPD has significantly improved patients’ quality life and outcomes. Few data are available regarding impact inhaler therapy on patients featuring Methods: We retrospectively evaluated inhale bronchodilators in a cohort 56 treated who underwent surgery primary Results: Triple bronchodilation can help to relieve...
Background: Tracheobronchial stenosis is a significant complication in granulomatosis with polyangiitis (GPA), systemic vasculitis that primarily affects the upper respiratory tract, kidneys, and lungs. The involvement of tracheobronchial tree GPA leads to airway narrowing, which can result severe symptoms increased morbidity, often requiring prompt diagnosis management prevent life-threatening obstruction. Method: We present case 28-year-old male mild exertional dyspnea, stridor,...
Background: Pleural mesothelioma (PM) is a rare and highly aggressive cancer which arises from mesothelial layer primarily linked to asbestos exposure, genetic predispositions, specific mutations. Despite current treatment modalities, including chemotherapy, antiangiogenic therapy more recently immunotherapy, the prognosis remains dismal, with median survival time of 6–18 months. Objectives: The urgent need for novel therapeutic strategies has prompted research into molecular targets...
Sarcoidosis is a multisystem disease, which diagnosed on compatible clinical presentation, non-necrotizing granulomatous inflammation in one or more tissue samples, and exclusion of alternative causes disease. Considering its heterogeneity, numerous aspects the disease remain to be elucidated. In this context, identification integration biomarkers may hold significance practice, aiding appropriate selection patients for targeted trials. This work aims discuss analyze how validated are...
Growing evidence suggests that sublobar resections offer more favorable outcomes than lobectomy in early-stage lung cancer surgery. However, a percentage of cases cannot be ignored develops disease recurrence irrespective the surgery performed with curative intent. The goal this work is thus to compare different surgical approaches, namely, and segmentectomy (typical atypical) derive prognostic predictive markers. Here we analyzed cohort 153 NSCLC patients clinical stage TNM I who underwent...
Interstitial lung diseases (ILDs) are a heterogeneous group of pulmonary disorders characterized by variable degrees inflammation, interstitial thickening, and fibrosis leading to distortion the architecture gas exchange impairment. Among them, idiopathic (IPF) displays worst prognosis. The only therapeutic options consist two antifibrotic drugs, pirfenidone nintedanib, which limit progression but do not reverse damage. shift pathogenetic paradigm from inflammatory disease epithelium-derived...
A 29-year-old man presented to Emergency Department with nonspecific symptoms. Through a series of radiological and invasive diagnostic studies we finally reach an unexpected diagnosis hypersentivity pneumonitis; this is complex heterogeneous disease which can be challenging as its clinical, radiologic histopathologic features overlap those other interstitial lung diseases (ILDs). Diagnosing ILD dynamic process, that the reason why cases discussed in multidisciplinary team may need...
Pulmonary hypertension (PH) is not considered a known risk factor for non-tuberculous mycobacterial lung disease (NTM-LD), despite that many studies state incidence almost equal to other chronic diseases. Current standard of care NTM-LD consists in multidrug antibiotic regimen several months. However, it results negative culture conversion minority cases. Therefore, when feasible an adjuvant surgical approach indicated. In this case report we highlight the importance muldisciplinary team...
Pulmonary hypertension (PH) is not considered a known risk factor for non-tuberculous mycobacterial lung disease (NTM-LD), despite that many studies state incidence almost equal to other chronic diseases. Current standard of care NTM-LD consists in multidrug antibiotic regimen several months. However, it results negative culture conversion minority cases. Therefore, when feasible an adjuvant surgical approach indicated. In this case report we highlight the importance multidisciplinary team...
A 64-year-old woman presented to Our Department with 2 weeks history of fever and cough. Through a series radiological invasive diagnostic studies we finally reach an unexpected diagnosis
The lungs are most often a preferential target organ for malignant spreading and growth. It is well known that chronic parenchymal inflammation prolonged injuries represents an independent risk factor cancer onset. Growing evidence supports the implication of lung microbiota in pathogenesis cancer. However, full interplay between inflammation, bacterial colonization, pathologic condition as bronchiectasis growth deserves better clarification. We here aim at presenting analyzing original data...
Novel coronavirus-related disease (COVID-19) has profoundly influenced hospital organization and structures worldwide. In Italy, the Lombardy Region, with almost 17% of Italian population, rapidly became most severely affected area since pandemic beginning. The first following COVID-19 surges significantly lung cancer diagnosis subsequent management. Much data have been already published regarding therapeutic repercussions whereas very few reports focused on consequences diagnostic...
Mesothelioma is a cancer arising from mesothelial cells lining the thoracic (pleura) or abdominal (peritoneum) cavities, and more rarely transformed of pericardium tunica vaginalis testis. The development mesothelioma has been related to exposure carcinogenic mineral fibers, mainly asbestos. Malignant an aggressive disease with diffuse nature, low median survival, prolonged latency presenting difficulty in prognosis, diagnosis, treatment. We here review all these aspects underline progress...
Despite low rates of bacterial co-infections, most COVID-19 patients receive antibiotic therapy. We hypothesized that with positive pneumococcal urinary antigens (PUAs) would benefit from therapy in terms clinical outcomes (death, ICU admission, and length stay). The San Matteo Registry (SMACORE) prospectively enrolls admitted for pneumonia at IRCCS Policlinico Matteo, Pavia. retrospectively extracted the data tested PUA October to December 2020. Demographic, clinical, laboratory were...
A 64-year-old woman presented to Our Department with 2 weeks history of fever and cough. Through a series radiological invasive diagnostic studies we finally reach an unexpected diagnosis Tsukamurella pneumonia; Diagnosing ILD is dynamic process, that the reason why complex cases discussed in multidisciplinary team may need be reconsidered light evolution disease results performed exams flexible approach. spp. obligate aerobic, Gram-positive, weakly acid-fast, non-motile bacilli belongs...
Hypersensitivity pneumonitis is a complex interstitial lung disease caused by exposure to an inhaled antigen. Most recent guidelines proposed categorize patients as having fibrotic or non-fibrotic subtype, mainly because the important implications for prognosis and treatment. Our focus based on relation between HP patients' smoking habits. Since 70's has been considered non-smoker disease, since it occurs more frequently in never smokers, although progression fibrosis related exposure. We...