A5072384152- Economic and Financial Impacts of Cancer
- Sarcoma Diagnosis and Treatment
- Medication Adherence and Compliance
- Telemedicine and Telehealth Implementation
- Renal cell carcinoma treatment
- Lymphoma Diagnosis and Treatment
- Pharmaceutical Economics and Policy
- Pharmaceutical Practices and Patient Outcomes
- COVID-19 and healthcare impacts
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Renal and related cancers
- Cutaneous lymphoproliferative disorders research
- Cancer-related molecular mechanisms research
- Gene Regulatory Network Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer survivorship and care
- Lung Cancer Research Studies
- Protein Degradation and Inhibitors
- Colorectal Cancer Screening and Detection
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver physiology and pathology
- Alcohol Consumption and Health Effects
Memorial Sloan Kettering Cancer Center
2022-2025
Varian Medical Systems (Switzerland)
2024
Pfizer (United Kingdom)
2024
Astellas Pharma (China)
2024
Bayer (Germany)
2024
AstraZeneca (Brazil)
2024
AstraZeneca (Finland)
2024
Kettering University
2023
Columbia University Irving Medical Center
2020-2022
Columbia University
2020
503 Background: LDTs, including surgical resection, radiation treatment and ablation/embolization, can be employed to achieve a disease-free state in indolent oligometastatic RCC irrespective of subtype. However, the efficacy LDTs chRCC, rare subtype, has not been investigated. We utilized multi-institutional chRCC dataset examine LDT use patterns associated duration disease control. Methods: Clinical characteristics patients with metachronous metastases were retrospectively collected from...
540 Background: Ipilimumab (IPI) and nivolumab (NIVO) are standard first-line systemic therapy for patients with metastatic renal cell carcinoma (RCC). The regimen is administered in combination once every 3 weeks 4 doses, followed by NIVO maintenance. dose frequency of IPI appears to correlate treatment safety tolerability across cancer types. Further, studies advanced melanoma have demonstrated that the efficacy + largely driven first two doses many (Postow MA et al., J Clin. Oncol. 2022)....
PURPOSE Clinical trials are integral for patients with cancer but remain inaccessible to many because of barriers including geographic and transportation challenges. This study aimed evaluate patients' preferences telemedicine versus in-person visits clinical trial discussions informed consent (IC). METHODS An electronic survey was administered first-time users at Memorial Sloan Kettering Cancer Center from 2021 2023. The assessed the IC process their comfort discussing virtually. primary...
Despite effective antiviral treatment, hundreds of kidneys from deceased donors with hepatitis C virus (HCV) are discarded annually. Little is known about the determinants willingness to accept HCV-infected among HCV-negative patients.At 2 centers, 189 patients undergoing initial or reevaluation for transplant made 12 hypothetical decisions accepting in which we systematically varied expected HCV cure rate, allograft quality, and wait time an uninfected kidney.Only 29% participants would...
Oral anticancer drugs (OACDs) have become increasingly prevalent over the past decade. OACD prescriptions require coordination between payers and providers, which can delay drug receipt. We examined association insurance type, pursuit of copayment assistance, prior authorization (PA), time to receipt (TTR) for new prescriptions.
In Brief Background Polycystic liver disease (PCLD) is characterized by cystic replacement of the hepatic parenchyma, leading to dysfunction, portal hypertension, and hepatomegaly. Patients with dysfunction and/or symptomatic are eligible for transplantation. However, little known about these patients' waitlist outcomes relative others chronic disease. Methods We used Organ Procurement Transplantation Network/United Network Sharing data from February 27, 2002 December 31, 2015 compare adult...
Background. Numerous barriers to outpatient colonoscopy completion exist, causing undue procedure cancellations and poor bowel preparation. We piloted a text message navigation program improve adherence. Method. conducted prospective study of patients aged 18 75 years scheduled for at an urban endoscopy center in April 2018. An intervention arm consisting bidirectional, automated messages prior the was compared with usual care arm. enrolled 21 by phone randomly selected 50 controls. Outcomes...
Modern cancer care is costly and logistically burdensome for patients their families despite an expansion of technology medical advances that create the opportunity novel approaches to care. Therefore, there a growing appreciation need leverage these innovations make more patient centered convenient. The Memorial Sloan Kettering Making Telehealth Delivery Cancer Care at Home Efficient Safe Research Center National Institute-designated funded Excellence poised generate evidence necessary...
Autoimmune hepatitis (AIH) may result in liver fibrosis and cirrhosis. While the gold standard for staging is biopsy, transient elastography (TE) represents a non-invasive alternative. TE has been validated several chronic diseases, but no data exist to establish an association between histologic on biopsy stiffness measurements among United States cohort of AIH patients.We conducted retrospective study 53 patients who received assessment biopsy. Histologic was classified as advanced (F3-F4)...
445 Background: Von Hippel Lindau ( VHL) gene function is uniformly lost in clear cell renal carcinoma (ccRCC) with consequent accumulation of hypoxia inducible factor 2 alpha (HIF-2α). HIF-2α inhibitors have entered the clinical arena as a new class agents, alone and combinations. While VHL loss thought to result broad increase activity, preclinical data suggests that target activation varies across patients. Xenograft response inhibition helped define an RNA-based signature (SIG)...
4512 Background: Chromophobe renal cell carcinoma (ChRCC) represents ~5-10% of all RCCs. Given its rarity, there is limited clinical trial data to guide systemic therapy for metastatic disease. Phase 2 trials have demonstrated that targeted agents inhibiting vascular endothelial growth factor receptor and mammalian target rapamycin similar efficacy in ChRCC compared conventional RCC. However, immune checkpoint inhibitor (IO) containing regimens appear less efficacious other RCC subtypes....
Abstract Purpose: To evaluate sitravatinib, an inhibitor of multiple receptor tyrosine kinases (RTK), for the treatment well-differentiated/dedifferentiated liposarcoma (WD/DD LPS). Patients and Methods: This multicenter, open-label, Phase II trial enrolled patients with advanced WD/DD LPS who had received at least one prior systemic regimen progression within 12 weeks enrollment. sitravatinib 150 mg (later amended to 120 mg) orally daily. A Simon two-stage design was used improvement in...
PURPOSE: Oral anticancer drug (OACD) prescriptions require extensive coordination between providers and payers, which can delay receipt. Specialty pharmacies facilitate communication multiple entities. In 2018, our cancer center partnered with a freestanding organization to implement hospital-based specialty pharmacy (HB-SP). We evaluated the time receipt (TTR) before after HB-SP implementation. METHODS: Data were prospectively collected on all new OACD for adult oncology patients from...
Patients heterozygous for an abnormal α-1 antitrypsin (A1AT) mutation may have increased risk of liver disease in the setting a secondary contributing factor.This single-center retrospective cohort study compared donor and recipient outcomes A1AT versus normal phenotype adult living-donor transplants (LDLTs).Between 2010 2016, 11 donors 10 recipients were to 57 41 recipients. There no significant differences sex, age, or race/ethnicity by phenotype. Heterozygous had significantly lower serum...
Oral anticancer drugs (OACDs) are increasingly prescribed for cancer treatment and require significant coordination of care. Retrospective studies suggest that 10% to 20% OACD prescriptions never received by the patients, but reasons behind this poorly understood.To estimate rate failure receive among patients with examine underlying failure.A prospective cohort study was conducted who were a new from January 1, 2018, December 31, 2019, at an urban academic medical center. Data analysis...
6 Background: The past decade has seen a dramatic increase in the number of Food and Drug Administration approvals oral anti-cancer drugs (OACDs). Most OACD prescriptions require coordination between payers providers, which can delay drug receipt. In May 2021, two bills were introduced US House Representatives (HR 3173 HR 3258) to streamline prior authorization (PA) process. this study, we examined clinical process-related factors associated with PA time receipt (TTR) for patients who...
1637 Background: The Making Telehealth Delivery of Cancer Care at Home Effective and Safe for Immunotherapy (MATCHES-IO) intervention seeks to improve the efficiency patient experience those treated with single agent pembrolizumab. Because pembrolizumab is administered as an outpatient infusion every 3-weeks, patients require up 18 clinic visits per year receive treatment, which arduous. During COVID-19 pandemic, FDA granted accelerated approval extended interval dosing 6 weeks, but despite...
1632 Background: Telemedicine, once sparingly utilized, surged during the COVID-19 pandemic to enhance care accessibility and safety concerns. Despite initial satisfaction, its usage remains highly variable across institutions. We sought explore patient satisfaction at a comprehensive cancer center, associations with demographic characteristics, change over time. Methods: A survey was sent all first-time telemedicine users Memorial Sloan Kettering Cancer Center from September 2021 October...