A5001505851- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Metabolomics and Mass Spectrometry Studies
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Inorganic and Organometallic Chemistry
- Bioinformatics and Genomic Networks
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Magnesium Oxide Properties and Applications
- Genomics and Rare Diseases
- Diet, Metabolism, and Disease
- Chemistry and Chemical Engineering
- Brain Metastases and Treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- BRCA gene mutations in cancer
- Advanced Proteomics Techniques and Applications
- Grouting, Rheology, and Soil Mechanics
- Minerals Flotation and Separation Techniques
- Environmental and Analytical Chemistry Studies
- Electrochemical Analysis and Applications
- History and advancements in chemistry
Memorial Sloan Kettering Cancer Center
2019-2024
Universidad de Salamanca
1971
Sociedad Española de Medicina Interna
1971
University College London
1971
Moorfields Eye Hospital
1971
Wellcome Trust Centre for the History of Medicine
1971
University of Pennsylvania
1930
Succinate dehydrogenase-deficient and fumarate hydratase-deficient renal cell carcinomas (SDHRCC FHRCC) are rare kidney cancers driven by loss of TCA cycle enzymes.To define compare the genomic metabolomic hallmarks SDHRCC FHRCC.We analyzed FHRCC tumors with either immunohistochemical evidence protein expression or genomically confirmed biallelic inactivation SDHA/B/C/D/AF2 FH.Somatic alterations were identified using clinical pipelines, allele-specific copy number (CNAs) FACETS. Mass...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTRIHALOGEN-METHYL REACTIONS. IV. REACTION OF TRICHLORO-ACETIC ACID WITH COPPERHoward Waters Doughty and Benjamin FreemanCite this: J. Am. Chem. Soc. 1922, 44, 3, 636–645Publication Date (Print):March 1, 1922Publication History Published online1 May 2002Published inissue 1 March 1922https://pubs.acs.org/doi/10.1021/ja01424a024https://doi.org/10.1021/ja01424a024research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Note on the Formation of Tri-Calcium Phosphate Mixing Ground Limestone with Acid Phosphate.R. N. Brackett and Benjamin FreemanCite this: Ind. Eng. Chem. 1915, 7, 620Publication Date (Print):July 1, 1915Publication History Published online1 May 2002Published inissue 1 July 1915https://pubs.acs.org/doi/10.1021/ie50079a025https://doi.org/10.1021/ie50079a025research-articleACS PublicationsRequest reuse permissionsArticle...
Breast cancer mortality rates are higher for African American women (AAW) than any other ethnic group in the United States. Recent reports suggest that outcome disparities between AAW and European (EAW) present ER+HER2- subtype. To improve our understanding, pathological characteristics, molecular profiles from treated within an equal-access health care system were evaluated.All (n=90) EAW (n=308) with tumors identified. Gene expression generated primary breast 57 181 EAW. Pathological...
Abstract Out of the thousands metabolites in a given specimen, most metabolomics experiments measure only hundreds, with poor overlap across experimental platforms. Here, we describe Metabolite Imputation via Rank-Transformation and Harmonization (MIRTH), method to impute unmeasured metabolite abundances by jointly modeling covariation datasets which have heterogeneous coverage features. MIRTH successfully recovers masked both within single multiple, independently-profiled datasets....
5040 Background: Patients (pts) with GCT and progressive disease (PD) after salvage high-dose chemotherapy (HDCT) have dismal outcomes median progression free survival (PFS) overall (OS) of 1.0 4.7 months (mo), respectively (Feldman et al. Cancer 2012). Immune checkpoint blockade (ICB) has resulted in durable benefit multiple tumor types. We tested D (anti-PD-L1) + T (anti-CTLA-4) for pts relapsed/refractory GCTs a phase II trial (NCT03158064). Methods: Eligible were ≥ 18 years old any...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTRIHALOGEN-METHYL REACTIONS. III. THE USE OF SILVER CATHODE IN ELECTRO-DEPOSITION COPPER.Howard Waters Doughty and Benjamin FreemanCite this: J. Am. Chem. Soc. 1921, 43, 4, 700–704Publication Date (Print):April 1, 1921Publication History Published online1 May 2002Published inissue 1 April 1921https://pubs.acs.org/doi/10.1021/ja01437a002https://doi.org/10.1021/ja01437a002research-articleACS PublicationsRequest reuse permissionsArticle...
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4526 Background: Molecular profiles of renal cell carcinoma (RCC) tumors are associated with systemic treatment (ST) responses and clinical outcomes. However, the molecular RCC brain metastases (BM) their correlation ST response outcomes not well characterized. Effective management BM locoregional therapies including stereotactic radiosurgery (SRS) is critical as advances have improved overall survival (OS). Therefore, we sought to identify genomic features in a large cohort patients treated...
Intratumoral genetic heterogeneity (ITH) poses a significant challenge to utilizing sequencing for decision making in the management of cancer. Although multiple tumor regions can address pitfalls ITH, it does so at increase cost and resource utilization. We propose pooled multiregional strategy, whereby DNA aliquots from are mixed prior sequencing, as cost-effective strategy boost translational value by addressing ITH while preserving valuable residual tissue secondary analysis. Focusing on...
ABSTRACT Intratumoral genetic heterogeneity (ITH) poses a significant challenge to utilizing sequencing for decision making in the management of cancer. Although multiple tumor regions can address pitfalls ITH, it does so at increase cost and resource utilization. We propose pooled multiregional strategy, whereby DNA aliquots from are mixed prior sequencing, as cost-effective strategy boost translational value by addressing ITH while preserving valuable residual tissue secondary analysis....
Abstract Purpose Succinate dehydrogenase-deficient and fumarate hydratase-deficient renal cell carcinomas (SDHRCC FHRCC) are rare kidney cancers driven by loss of metabolically proximal enzymes. We sought to define compare the genomic metabolomic hallmarks these entities. Experimental Design analyzed SDHRCC FHRCC tumors with either immunohistochemical evidence protein expression or genomically-confirmed biallelic inactivation SDHA/B/C/D/AF2 FH. Somatic alterations were identified using...
You have accessJournal of UrologyKidney Cancer: Basic Research & Pathophysiology I (MP39)1 Sep 2021MP39-08 GENOMIC AND METABOLIC HALLMARKS OF TCA-CYCLE-MUTANT RENAL CELL CARCINOMAS Angela Yoo, Cerise Tang, Mark Zucker, Kelly Fitzgerald, Phillip Rappold, Kate Weiss, Benjamin Freeman, Chung-Han Lee, Maria Carlo, Ritesh Kotecha, A Ari Hakimi, and Ed Reznik YooAngela Yoo More articles by this author , TangCerise Tang ZuckerMark Zucker FitzgeraldKelly Fitzgerald RappoldPhillip Rappold WeissKate...