A5081734358- Inflammasome and immune disorders
- Platelet Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Respiratory viral infections research
- Body Composition Measurement Techniques
- Electroconvulsive Therapy Studies
- Hematological disorders and diagnostics
- Inflammatory Myopathies and Dermatomyositis
- Autoimmune Bullous Skin Diseases
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Genetic Syndromes and Imprinting
- Obesity, Physical Activity, Diet
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Urticaria and Related Conditions
- Advanced biosensing and bioanalysis techniques
- Neonatal Respiratory Health Research
- Cell Adhesion Molecules Research
- Health and Lifestyle Studies
- IgG4-Related and Inflammatory Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lymphoma Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
University of Michigan
2015-2025
C. S. Mott Children's Hospital
2023
National Diabetes Obesity and Cholesterol Foundation
2017
Diabetes Foundation
2017
Abstract Novel therapeutics are required for improving the management of chronic inflammatory diseases. Aptamers single-stranded RNA or DNA molecules that have recently shown utility in a clinical setting, as they can specifically neutralize biomedically relevant proteins, particularly cell surface and extracellular proteins. The nuclear chromatin protein DEK is secreted chemoattractant abundant synovia patients with juvenile idiopathic arthritis (JIA). Here, we show crucial to development...
Systemic lupus erythematosus (SLE) is characterized by increased cardiovascular risk in adult-onset and childhood-onset SLE. Type I interferons (IFNs) appear to play a prominent role premature vascular damage SLE, at least part, inducing impairments the phenotype function of endothelial progenitor cells (EPCs), thereby hampering repair. It not clear whether EPC dysfunction present SLE association with type IFN signature.The numbers EPCs were quantified patients juvenile idiopathic arthritis...
Skin inflammation in juvenile dermatomyositis (JDM) can signal disease onset or flare, and the persistence of cutaneous prevent complete remission. The non-invasive study expression signatures through tape stripping (TS) holds potential to reveal mechanisms underlying heterogeneity organ-specific inflammation. objectives this were 1) define TS lesional non-lesional JDM skin, 2) analyze identify endotypes 3) compare blood signatures. While skin demonstrated interferon signaling as top...
Background . We studied the impact of multicomponent interventions on body weight and cardiometabolic risk factors in overweight individuals working corporate worksites. Methods Overweight (BMI ≥ 23 kg/m 2 ) subjects were recruited from four randomised worksites [two active intervention ( n , recruited, 180, completed 156) two control 130, 111)]. Intensive was given at worksite. Results High prevalence (%) obesity (90.9, 80.2), abdominal (93.5, 84.3), excess skinfold thickness (70.3, 75.9),...
Objective The nuclear oncoprotein DEK is an autoantigen associated with juvenile idiopathic arthritis ( JIA ), especially the oligoarticular subtype. a secreted chemotactic factor. Abundant levels of and autoantibodies are found in inflamed synovium . We undertook this study to further characterize nature screening serum samples from 2 different cohorts that consisted mostly patients Methods autoantibody were analyzed sera 33 patients, 13 other inflammatory conditions, 11 healthy controls,...
A 13-year-old girl with neuropsychiatric systemic lupus erythematosus presenting psychosis and persistent catatonia unresponsive to immunosuppressive agents a benzodiazepine was successfully treated ECT.
The impact of the COVID-19 pandemic on new diagnoses recurrent fevers and autoinflammatory diseases is largely unknown. Childhood Arthritis Rheumatology Research Alliance (CARRA) PFAPA/AID Working Group aimed to investigate number pediatric patients evaluated for in North America. absolute outpatient visits proportion these attributed fever during pre-pandemic period (1 March 2019–29 February 2020) first year 2020–28 2021) were examined. Data collected from 27 sites United States Canada. Our...
Both granulomatous polyangiitis (GPA) and Crohn’s disease (CD) can cause orbital inflammation though rarely coincide often be differentiated by presenting features histological findings. Here, we report the clinical therapeutic course of a 14-year-old White male with binocular diplopia caused myositis. Imaging biopsy obtained at presentation revealed necrosis necrotizing vasculitis suspicious for GPA. He subsequently developed gastrointestinal symptoms terminal ileitis consistent CD. Orbital...