William G Ambler
A5084788010- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Lymphatic System and Diseases
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Kawasaki Disease and Coronary Complications
- Circadian rhythm and melatonin
- Intracerebral and Subarachnoid Hemorrhage Research
- Immune cells in cancer
- Autoimmune Bullous Skin Diseases
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Atherosclerosis and Cardiovascular Diseases
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Systemic Sclerosis and Related Diseases
- Engineering Education and Pedagogy
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Barrier Structure and Function Studies
New York Proton Center
2022-2024
Hospital for Special Surgery
2021-2024
Cornell University
1902-2024
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2024
National Institutes of Health
2024
Connecticut Children's Medical Center
2024
University of California, San Francisco
2021
Alberta Children's Hospital
2021
University of Calgary
2021
UConn Health
2014
The autoimmune disease lupus erythematosus (lupus) is characterized by photosensitivity, where even ambient ultraviolet radiation (UVR) exposure can lead to development of inflammatory skin lesions. We have previously shown that Langerhans cells (LCs) limit keratinocyte apoptosis and photosensitivity via a disintegrin metalloprotease 17 (ADAM17)-mediated release epidermal growth factor receptor (EGFR) ligands LC ADAM17 sheddase activity reduced in lupus. Here, we sought understand how the...
Intracerebral hemorrhage (ICH) is swiftly followed by an inflammatory response. A key component of this response the recruitment leukocytes into brain, which promotes neurological injury in rodent models. However, mechanisms transmigrate across endothelium injured brain are unclear. The present study examines leukocyte adhesion molecules (α4 integrin, L-selectin, and αLβ2 integrin) on 4 subtypes to determine important for after ICH.We used blood injection mouse model ICH, whereby 25 μL was...
An important pathogenic role for neutrophils in systemic lupus erythematosus (SLE) has been proposed. Neutrophils that lack brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (
Abstract Background Children with juvenile idiopathic arthritis (JIA) who achieve a drug free remission often experience flare of their disease requiring either intraarticular steroids (IAS) or systemic treatment modifying anti-rheumatic drugs (DMARDs). IAS offer an opportunity to recapture control and avoid exposure side effects from immunosuppression. We examined cohort patients treated after report the probability restarting within 12 months. Methods analyzed Childhood Arthritis...
The impact of social determinants health on children with polyarticular juvenile idiopathic arthritis (pJIA) is poorly understood. Prompt initiation treatment for pJIA important to prevent disease morbidity; however, a potential barrier early pJIAs delayed presentation pediatric rheumatologist. We examined the community poverty level, key determinant health, time from patient reported symptom onset first rheumatology visit among patients enrolled in Childhood Arthritis and Rheumatology...
<h3>Background</h3> The autoimmune disease lupus erythematosus (lupus) is characterized by photosensitivity, where even ambient ultraviolet radiation (UVR) exposure inflames skin. Beneficial effects of anifrolumab (anti-interferon α/βreceptor (anti-IFNAR)) on skin support a pathogenic role for IFN-I , but mechanistic understanding limited. We have shown that Langerhans cell (LC) dysfunction contributes to photosensitivity. Healthy LCs act via disintegrin and metalloprotease 17 (ADAM17)...
Chronic anterior uveitis (CAU) carries a significant risk for eye complications and vision loss. The Childhood Arthritis Rheumatology Research Alliance (CARRA) introduced consensus treatment plans (CTPs) to standardize CAU facilitate future comparative effectiveness studies. Two CTPs were developed address: 1) initiation of methotrexate (MTX) in patients with naïve steroid-sparing therapy, 2) TNF inhibitor (TNFi) severe or refractory MTX. We evaluated implementation the using existing CARRA...
Department of Physics recently installed in the basement main laboratory a plant for production liquid air experimental purposes, and number tests have been made to determine its output efficiency.The installation consists separate compressor liquefier, former being belt-driven from an independent direct-current electric motor.The was built by Norwalk Iron Works is furnished with Hampson liquefier Brin's Oxygen Co., Limited, London.The four-stage type cylinders 7%-, $%-, 2-and i-inch...
Abstract Background We aimed to characterize etanercept (ETN) use in juvenile idiopathic arthritis (JIA) patients enrolled the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. Methods The CARRA Registry is a convenience cohort of with paediatric onset rheumatic diseases, including JIA. JIA treated ETN for whom month year initiation were available included. Patterns methotrexate (MTX) categorized as follows: combination therapy (ETN MTX started concurrently), step-up...
To describe 2-year trajectories of the clinical Juvenile Arthritis Disease Activity Score, 10 joints (cJADAS10) and associated baseline characteristics in patients with JIA.JIA Childhood Rheumatology Research Alliance Registry enrolled within 3 months diagnosis from 15 June 2015 to 6 December 2017 at least two cJADAS10 scores 24 follow-up were included. Latent growth curve models analysed; a combination Bayesian information criterion, posterior probabilities judgement was used select model...
Abstract Patients with systemic lupus erythematosus (SLE) are photosensitive, developing skin inflammation even ambient ultraviolet radiation (UVR), and this cutaneous photosensitivity can be associated UVR-induced flares of disease, which involve increased autoantibodies further end organ injury. Mechanistic insight into the link between responses autoimmunity is limited. Signals from transmitted directly to immune system via lymphatic vessels, here we show evidence for potentiation flow...
ABSTRACT Background The autoimmune disease lupus erythematosus (lupus) is characterized by photosensitivity, where even ambient ultraviolet radiation (UVR) exposure inflames skin. Beneficial effects of anifrolumab (anti-interferon α/breceptor (anti-IFNAR)) on skin support a pathogenic role for IFN-I, but mechanistic understanding limited. We have shown that Langerhans cell (LC) dysfunction contributes to photosensitivity. Healthy LCs act via disintegrin and metalloprotease 17 (ADAM17)...
<h3>Background</h3> The lymphatic system is composed of vessels which carry fluid, soluble molecules, and cells from peripheral tissue to draining lymph nodes. Photosensitivity, an exaggerated inflammatory response in ultraviolet radiation (UVR), present most patients with Systemic Lupus Erythematosus (SLE). Lymphatic dysfunction has been shown induce photosensitivity wild-type models, thus we hypothesized that could contribute SLE. <h3>Methods</h3> We examined MRL/lpr lupus prone mice for...
<h3></h3> Patients with systemic lupus erythematosus (SLE) are photosensitive, developing skin inflammation even ambient ultraviolet radiation (UVR), and this cutaneous photosensitivity can be associated UVR-induced flares of disease, increased autoantibodies further end organ injury. Mechanistic insight into the link between disease autoimmunity is limited. Signals from transmitted directly to immune system via lymphatic vessels, here we show evidence for potentiation flow dysfunction in...
Background: Intracerebral hemorrhage (ICH) triggers an immune response leading to leukocyte recruitment the brain and secondary injury. Inflammatory monocytes traffic over first 3 days after ICH in murine models, genetic knock-outs that lack these cells have improved functional outcomes. The aim of this study was determine adhesion molecules used by enter brain, whether antagonism candidate could be a new therapeutic target. Methods: modeled via injection collagenase into right striatum wild...
Abstract Photosensitivity, a sensitivity to ultraviolet radiation, is hallmark symptom of systemic and cutaneous lupus erythematosus (SLE CLE). We have previously shown that photosensitivity in SLE models caused by reduced function Langerhans cells (LC) disintegrin metalloprotease 17 (ADAM17), sheddase normally limits UVR-induced skin inflammation activating epidermal growth factor receptor (EGFR) ligands. also showed LC ADAM17 activity murine human this dysfunction contributed...
<h3>Background</h3> In SLE, that ultraviolet radiation exposure can induce both photosensitive skin responses and increased autoantibody titers suggests a critical targetable role for the communication from to draining lymph nodes in regulating node B cell responses. Lymphatic vessels bring cells signals regulate immunity dysfunction of lymphatic flow has potential alter immunity. Here we examine function SLE humans models, showing is compromised. improving by manual drainage (MLD) or...