A5014374310- Lymphatic System and Diseases
- Sympathectomy and Hyperhidrosis Treatments
- Dermatology and Skin Diseases
- Systemic Sclerosis and Related Diseases
- Psoriasis: Treatment and Pathogenesis
- Lymphatic Disorders and Treatments
- Angiogenesis and VEGF in Cancer
- Atherosclerosis and Cardiovascular Diseases
- Cancer Cells and Metastasis
- Myofascial pain diagnosis and treatment
- Planarian Biology and Electrostimulation
- Diagnosis and Treatment of Venous Diseases
- Culinary Culture and Tourism
- Heart Rate Variability and Autonomic Control
- Entomological Studies and Ecology
- Vascular Malformations and Hemangiomas
- Allergic Rhinitis and Sensitization
- Sensory Analysis and Statistical Methods
- Dietary Effects on Health
- Adipokines, Inflammation, and Metabolic Diseases
- Thermoregulation and physiological responses
- Retinopathy of Prematurity Studies
- Ubiquitin and proteasome pathways
- Systemic Lupus Erythematosus Research
- Cerebrospinal fluid and hydrocephalus
Memorial Sloan Kettering Cancer Center
2019-2025
Creative Commons
2023
Cornell University
2022
Weill Cornell Medicine
2022
New York Proton Center
2022
Inje University
2022
Temple University
2016
Recent studies suggest that Th2 cells play a key role in the pathology of secondary lymphedema by elaborating cytokines such as IL4 and IL13. The aim this study was to test efficacy QBX258, monoclonal IL4/IL13 neutralizing antibody, women with breast cancer-related (BCRL). We enrolled nine unilateral stage I/II BCRL treated them once monthly intravenous infusions QBX258 for 4 months. measured limb volumes, bioimpedance, skin tonometry, analyzed quality life (QOL) using validated...
Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3), a tyrosine kinase encoded by the FLT4 gene, plays significant role in morphogenesis and maintenance of lymphatic vessels. Under both normal pathologic conditions, VEGF-C VEGF-D bind VEGFR3 on surface cells (LECs) induce proliferation, migration, survival activating intracellular PI3K-Akt MAPK-ERK signaling pathways. Impaired function has been linked with myriad commonly encountered clinical conditions. This review provides brief...
Proliferation of aberrant, dysfunctional lymphatic vessels around solid tumors is a common histologic finding. Studies have shown that abnormalities in function result accumulation inflammatory cells with an immunosuppressive profile. We tested the hypothesis surrounding regulate changes tumor microenvironment and tumor-specific immune responses. Using subcutaneously implanted mouse melanoma breast cancer endothelial cell-specific diphtheria toxin receptor transgenic mouse, we found local...
Lymphatic structure and function play a critical role in fluid transport, antigen delivery, immune homeostasis. A dysfunctional lymphatic system is associated with chronic low-grade inflammation of peripheral tissues, poor responses, recurrent infections, which are also hallmarks aging pathology. Previous studies have shown that impairs variety organ systems, including the intestines central nervous system. However, previous mostly limited to qualitative analysis structural changes...
Obesity results in lymphatic dysfunction, but the cellular mechanisms that mediate this effect remain largely unknown. Previous studies obese mice have shown inducible nitric oxide synthase-expressing (iNOS+) inflammatory cells accumulate around vessels. In current study, we therefore tested hypothesis increased expression of iNOS nitrosative stress and injury to endothelial (LECs). addition, injury, independent obesity, can modulate glucose lipid metabolism.We compared metabolic changes...
The lymphatic network can be expanded in size and function by enhancing intracellular VEGFR3 signaling.
Steady-state lymphatic endothelial cells (LECs) can induce peripheral tolerance by presenting endogenous antigens on MHC class I (MHC-I) molecules. Recent evidence suggests that lymph node LECs cross-present tumor MHC-I to suppress tumor-specific CD8+ T cells. Whether act as immunosuppressive in an MHC-II dependent manner the local microenvironment (TME) is not well characterized. Using murine heterotopic and spontaneous models, we show TME increase expression context of increased...
Lymphedema is a chronic condition that commonly occur from lymphatic injury following surgical resection of solid malignancies. While many studies have centered on the molecular and immune pathways perpetuate dysfunction, role skin microbiome in lymphedema development remains unclear. In this study, swabs collected normal forearms 30 patients with unilateral upper extremity were analyzed by 16S ribosomal RNA sequencing. Statistical models for data utilized to correlate clinical variables...
Purpose: Secondary lymphedema (LE) is well recognized as a T-helper (Th) mediated inflammatory disease. However, the fact that only 30% of patients undergoing axillary lymph node dissection (ALND) develop LE, suggest some may be predisposed to developing In recent sequencing analysis CD4+ T-cells in LE clinical biopsy samples our lab an oligoclonal repertoire with high T-cell receptor (TCR) affinity for self-antigen, insulin, highlighting possible autoimmune component development. Several...
PURPOSE: Secondary lymphedema (LE) is a chronic T-cell mediated disease. Clonal analysis of the CD4+ Tcells in clinical LE skin biopsies suggests that specific activating antigens contribute to responses are necessary for development. Thus, aim this study was characterize dendritic cell (DC) subset dictates antigen presentation and ultimately fate secondary lymphedema. METHODS: We utilized popliteal lymph node dissection (PLND) model analyzed conventional DC (cDC) subsets ipsilateral,...
TRPV4 channels are critical regulators of blood vascular function and have been shown to be dysregulated in many disease conditions association with inflammation tissue fibrosis. These key features the pathophysiology lymphatic system diseases, including lymphedema lipedema; however, role remains largely unexplored. calcium permeable, non-selective cation that activated by diverse stimuli, shear stress, stretch, temperature, cell metabolites, which may regulate contractile function.
Secondary lymphedema is a common complication following surgical treatment of solid tumors. Although more prevalent in women due to higher breast cancer rates, men also develop lymphedema, often with severe manifestations. Despite these differences clinical presentation, the cellular mechanisms underlying sex are poorly understood. Previous studies have shown that inducible nitric oxide synthase (iNOS) expression by inflammatory cells an important regulator lymphatic pumping and leakiness...
Abstract Epidermal changes are histological hallmarks of secondary lymphedema, but it is unknown if keratinocytes contribute to its pathophysiology. Using clinical lymphedema specimens and mouse models, we show that play a primary role in development by producing T-helper 2 (Th2) -inducing cytokines. Specifically, find keratinocyte proliferation expression protease-activated receptor (PAR2) early responses following lymphatic injury regulate the Th2-inducing cytokines, migration Langerhans...
Abstract Patients with systemic lupus erythematosus (SLE) are photosensitive, developing skin inflammation even ambient ultraviolet radiation (UVR), and this cutaneous photosensitivity can be associated UVR-induced flares of disease, which involve increased autoantibodies further end organ injury. Mechanistic insight into the link between responses autoimmunity is limited. Signals from transmitted directly to immune system via lymphatic vessels, here we show evidence for potentiation flow...
Mutations of Crb1 gene cause irreversible and incurable visual impairment in humans. This study aims to use an LCA8-like mouse model identify host-mediated responses that might interfere with survival, retinal integration differentiation grafted cells during neonatal cell therapy. Mixed donor (1 ~ 2 × 104) isolated from neural retinas eGFP transgenic mice were injected into the subretinal space mice. Markers specific types used analyze microglial attraction, CSPG induction differentiation....
<h3></h3> Patients with systemic lupus erythematosus (SLE) are photosensitive, developing skin inflammation even ambient ultraviolet radiation (UVR), and this cutaneous photosensitivity can be associated UVR-induced flares of disease, increased autoantibodies further end organ injury. Mechanistic insight into the link between disease autoimmunity is limited. Signals from transmitted directly to immune system via lymphatic vessels, here we show evidence for potentiation flow dysfunction in...