A5022139023- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Cancer Treatment and Pharmacology
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Systemic Lupus Erythematosus Research
- Advanced Breast Cancer Therapies
- Osteomyelitis and Bone Disorders Research
- Infectious Diseases and Tuberculosis
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Lipids, and Metabolism
- Orthopedic Infections and Treatments
- Cancer Cells and Metastasis
- Chronic Myeloid Leukemia Treatments
- PARP inhibition in cancer therapy
- Vitamin D Research Studies
- Viral-associated cancers and disorders
- Wnt/β-catenin signaling in development and cancer
- Atherosclerosis and Cardiovascular Diseases
- Metabolism, Diabetes, and Cancer
- Inflammasome and immune disorders
- DNA Repair Mechanisms
- Pediatric Urology and Nephrology Studies
University Hospital Olomouc
2006-2025
Palacký University Olomouc
2015-2025
Weatherford College
2024
Institute of State Administration
2024
Ocní klinika
2022
Institute of Molecular and Translational Medicine
2011-2018
University Hospital Brno
2017
Hôpital René Huguenin
2010
Institut Curie
2010
Masaryk Memorial Cancer Institute
2005
Collagen triple helix repeat containing 1 (CTHRC1) affects Wnt signalling, collagen deposition and bone formation. It is an extracellular matrix protein which also abnormally expressed in the tumour microenvironment. CTHRC1 has not been studied breast cancer by immunohistochemistry.To examine expression of together with periostin versican patients investigate its association clinicopathological characteristics.The formalin-fixed paraffin-embedded tissues 173 invasive carcinomas (classified...
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Insulin resistance (IR) is a key and early pathogenetic mechanism of cardiometabolic diseases with huge potential if detected mitigated, for lowering the burden disease. Available data are conflicting to what extent adult thyroid dysfunction associated IR. Therefore, we aimed investigate association identify which parameters predictors IR.After undergoing basic anthropometric biochemical studies including hormones, oral glucose tolerance test (OGTT), insulin, 1425 middle-aged individuals...
Neither targeted therapies nor predictors for chemotherapy sensitivity are available triple-negative breast cancer (TNBC). Our study included 187 patients with TNBC, 164 of whom were treated anthracycline-based adjuvant chemotherapy. Eleven molecular biomarkers analyzed. BCL2, epidermal growth factor receptor (EGFR), MYC, TOP2A, and Ki-67 protein expression was evaluated by immunohistochemistry. The status the EGFR, TOP2A genes chromosomes 7, 8, 17 assessed using fluorescence in situ...
Abstract Objectives Clinical phenotyping and predicting treatment responses in SLE patients is challenging. Extensive blood transcriptional profiling has identified various gene modules that are promising for stratification of patients. We aimed to translate existing transcriptomic data into simpler signatures suitable daily clinical practice. Methods Real-time PCR multiple genes from the IFN M1.2, M5.12, neutrophil (NPh) plasma cell (PLC) modules, followed by a principle component analysis,...
Background: A total of 30–40% diffuse large B cell lymphoma (DLBCL) patients will either not respond to the standard therapy or their disease recur. The first-line treatment for DLBCL is rituximab and combination chemotherapy. This involves chemotherapy-induced recruitment tumor-associated macrophages that recognize kill rituximab-opsonized cells. However, we lack insights into factors responsible functionality in tumors. Methods: We have studied effects immunomodulatory lipid...
Eligibility to anti‐HER2 therapy for breast tumors strictly depends on demonstrating HER2 overexpression (by immunohistochemistry) or gene amplification by in situ hybridization (ISH), usually defined the ratio of chromosome 17 centromere (CEP17) copies. However, CEP17 copy number increase (CNI) has been proven responsible misleading FISH results and recent small cohort studies suggest that polysomy is actually very rare. Here we investigated frequency true a consecutive 5,477 invasive...
Individuals with congenital solitary functioning kidney (SFK) are at an increased risk of damage. According to some studies, the is higher in unilateral agenesis (UKA) than multicystic dysplastic (UMCDK). We hypothesized that early detection children UKA and UMCDK, there would be no difference presence hypertension, proteinuria, reduced glomerular filtration rate (GFR) between UMCDK.
We report here a case of newborn with hypotrophy and somatic stigmatization: microcephaly, facial dysmorphism, heart defect immunodeficiency syndrome. The proband's karyotype was 46,XY,dup(4)(q28q35.2) de novo chromosomal breaks in 4% metaphases. demonstrate the usefulness combination physical examination, classical cytogenetics, FISH PCR techniques order to establish correct diagnosis because overlap some clinical cytogenetic features Nijmegen breakage syndrome (NBS) duplication 4q our...
With an increasing number of cancer patients receiving tyrosine kinase inhibitors (TKIs), therapeutic drug monitoring these molecules is becoming more widespread today. It mainly based on liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) methods typical run times several minutes. In online solid phase extraction-MS/MS (SPE-MS/MS) system, the column replaced a reusable extraction (SPE) cartridge and analysis time shortened to less than half minute. The aim this study was...
Lapatinib is a tyrosine kinase inhibitor targeting epidermal growth factor receptors 1 (EGFR/HER1) and 2 (HER2) used in the treatment of patients with HER2-positive breast cancer. The aim present study was to determine lapatinib plasma levels cancer treated plus capecitabine.We assessed blood samples from 21 capecitabine using standard regimen an expanded access program. Liquid chromatography tandem mass spectrometry for measuring concentrations. validated method applied measurement 55...
Lapatinib is a tyrosine kinase inhibitor targeting epidermal growth factor receptors 1 (EGFR/HER1) and 2 (HER2) used in the treatment of patients with HER2-positive breast cancer. The aim present study was to determine lapatinib plasma levels cancer treated plus capecitabine.We assessed blood samples from 21 capecitabine using standard regimen an expanded access program. Liquid chromatography tandem mass spectrometry for measuring concentrations. validated method applied measurement 55...
1087 Background: Preclinical data show an association of BCL2 expression and resistance to anthracyclines. The absence in prechemotherapy samples is associated with a higher probability pathological complete response neoadjuvant doxorubicin-based chemotherapy. aim our research identification markers predicting sensitivity adjuvant treatment TNBC. Here we focus on protein as putative predictor anthracycline-based objective was determine whether predicts relapse TNBC patients treated regimens....
Juvenile primary Sjögren syndrome (pSS) with renal involvement is extremely rare, reported approximately in 50 children, predominantly girls. Here, we present the first case of a male child juvenile pSS ocular surface disease (previously keratoconjunctivitis sicca), submandibular salivary gland involvement, and tubulointerstitial nephritis. First, two symptoms were clinically apparent at presentation. We illustrate here that kidney should be actively looked for, as may associated...