A5043261933- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Chromatin Remodeling and Cancer
- Cancer Mechanisms and Therapy
- Advances in Oncology and Radiotherapy
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Ophthalmology and Eye Disorders
- Ocular Oncology and Treatments
- Artificial Intelligence in Healthcare and Education
- Global Health and Surgery
- Cancer, Hypoxia, and Metabolism
- Management of metastatic bone disease
- Ethics and Legal Issues in Pediatric Healthcare
- Cancer-related Molecular Pathways
- Bone and Dental Protein Studies
- Hedgehog Signaling Pathway Studies
- Protein Degradation and Inhibitors
- Medicinal Plant Pharmacodynamics Research
- Neurofibromatosis and Schwannoma Cases
- Nanoplatforms for cancer theranostics
Hospital Sant Joan de Déu Barcelona
2016-2025
Institut de Recerca Sant Joan de Déu
2018
University of Chicago
2011-2013
Background/Objectives: Pediatric cancer patients and their families are increasingly combining conventional treatment with complementary therapies. These therapies not covered by most public healthcare systems, Spain is an exception. To address this need, the Cancer Center Barcelona, at Hospital Sant Joan de Déu (Spain), established first integrative pediatric oncology unit in 2019. The objective of study to describe feasibility implementing a unit, terms acceptance interventions, as well...
Abstract The survival rates for children with cancer have increased appreciably over the last few decades; however, childhood survivors continue to suffer from long-lasting sequelae. Studies demonstrated that presence of malnutrition, over- and under-nutrition, at diagnosis or duration malnutrition during treatment is associated toxicity, infection, inferior survival. Dietary habits, along behavioral socioeconomic status, are known factors lead obesity undernutrition can affect prognosis...
Von Hippel-Lindau disease is a genetic disorder characterised by the development of variety tumours and cysts, with central nervous system (CNS) haemangioblastoma being most common manifestation. Early diagnosis through counselling surveillance crucial for detecting asymptomatic stages to minimise morbidity mortality associated tumour complications treatment interventions. In this report, we describe two cases very early-onset symptomatic CNS discuss potential improvement in protocols...
Secreted Protein Acidic and Rich in Cysteine (SPARC) is one of the major non-structural proteins extracellular matrix (ECM) remodeling tissues. The functional significance SPARC emphasized by its origin first multicellular organisms high degree evolutionary conservation. Although has been shown to act as a critical modulator ECM with profound effects on tissue physiology architecture, no plausible molecular mechanism action proposed. In present study, we demonstrate that mediates disassembly...
Somatic mutations in ACVR1 are found a quarter of children with diffuse intrinsic pontine glioma (DIPG), but there no inhibitors licensed for the disease. Using an artificial intelligence-based platform to search approved compounds ACVR1-mutant DIPG, combination vandetanib and everolimus was identified as possible therapeutic approach. Vandetanib, inhibitor VEGFR/RET/EGFR, target (K d = 150 nmol/L) reduce DIPG cell viability vitro has limited ability cross blood-brain barrier. In addition...
Purpose The aim of this study is to investigate the spectrum neurological triad improvement in patients with diffuse intrinsic pontine glioma (DIPG) treated by re-irradiation (re-RT) at first progression. Methods We carried out a re-analysis SIOP-E retrospective DIPG cohort investigating clinical benefits after re-RT focus on (cranial nerve deficits, ataxia, and long tract signs). Patients were categorized as “responding” or “non-responding” re-RT. To assess interdependence between patients’...
Abstract Purpose Brain stem tumors in children < 3 months at diagnosis are extremely rare. Our aim is to study a retrospective cohort improve the understanding of disease course and guide patient management. Methods This multicenter analysis across European Society for Pediatric Oncology SIOP-E HGG/DIPG Working Group linked centers, including patients with brainstem tumor diagnosed between 2009 2020 aged diagnosis. Clinical data were collected, imaging characteristics analyzed blindly...
Abstract Background Li-Fraumeni Syndrome (LFS) is a cancer predisposition syndrome characterized by the early-onset of multiple primary cancers which can occur at different moments (metachronous onset) or, more rarely, coincidentally (synchronous onset). Here we describe previously unreported patient with presentation synchronous Wilms tumor and Choroid plexus papilloma, leading to diagnosis (LFS). Case A 6-year-old girl without previous complains presented abdominal pain. Abdominal US MRI...
Abstract Background Since 2013, pediatric oncologists from Central and South America discuss neuro‐oncology cases with experts North Europe in a web‐based “Latin American Tumor Board” (LATB). Here, we evaluate the feasibility of recommendations rendered by Board. Methods An electronic questionnaire was distributed to physicians who had received between October 2017 2018. Physicians were asked regarding each recommendation given during LATB discussion. Baseline case characteristics all...
OBJECTIVEDiffuse intrinsic pontine glioma (DIPG) is a highly aggressive and lethal brainstem tumor in children. In the 1980s, routine biopsy at presentation was abandoned since it claimed "unnecessary" for diagnosis. last decade, however, several groups have reincorporated this procedure as standard of care or context clinical trials. Expert neurosurgical teams report no mortality acceptable morbidity, relevant complications been previously described. The aim study to review needle tract...
Central nervous system high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1) is a rare recently described entity. Fourteen CNS HGNET-MN1 patients were identified using genome-wide methylation arrays/RT-PCR across seven institutions. All had surgery (gross total resection: 10; subtotal four) as initial management followed by observation alone in three patients, radiotherapy eight (focal: five; craniospinal: two; CyberKnife: one) and systemic chemotherapy patients. Seven...
PurposePediatric low-grade gliomas (PLGG) have an excellent overall survival, but frequently need non-surgical therapy at diagnosis or after progression when located in unresectable sites such as the optic pathway. Chemotherapy side effects led to for better-tolerated regimens with a sustained response. Bevacizumab, humanized anti-VEGF monoclonal antibody has been used monotherapy and/or combination these entities. Here we present our experience its use PLGG.MethodsThe authors performed...
The authors declare that there is no conflict of interest.
PURPOSE Pediatric neuro-oncology resources are mostly unknown in Chile. We report the human and material available Chilean hospitals providing pediatric services. METHODS A cross-sectional survey was distributed to 17 services (Programa Infantil Nacional de Drogas Antineoplásicas [PINDA] hospitals, 11; private, 6). RESULTS Response rate 71% (PINDA, 8; 4). were mainly provided within general (67%). Registries for CNS tumors chemotherapy-related toxicities 100% 67% of respectively. treated by...
Abstract BACKGROUND Bithalamic gliomas (BTG) are rare brain tumors with dismal prognosis. Optimal management and role of novel therapies have not been established yet. This study aimed to improve our understanding BTG guide adapted treatments. METHODS Retrospective case series across 6 Pediatric Neuro-Oncology Units (United Kingdom, Spain) ≤18-year-old patients between 2000-2022. Clinical, pathological, molecular data were derived reviewed. A systematic review the literature, meta-analysis,...
Abstract BACKGROUND Brainstem gliomas account for 10-20% of all central nervous system pediatric neoplasms. Brain stem tumors in children less than three months old at diagnosis are extremely rare. Our aim is to study a retrospective cohort improve the understanding disease course and guide patient management. METHODS This multicenter analysis across European Society Pediatric Oncology SIOP-E HGG/DIPG Working Group linked centers included patients with brainstem tumor diagnosed between 2009...
Abstract BACKGROUND The evaluation of existing resources and services is key to identify gaps prioritize interventions expand care capacity for children with central nervous system (CNS) tumors. We sought evaluate the pediatrc neuro-oncology (PNO) in Mexico. METHODS A cross-sectional online survey 35 items was designed assess PNO services. distributed members Mexican Association Pediatric Oncology Hematology (AMOHP). RESULTS Overall, responses from 33 institutions were obtained. Responding...