A5017283956- Cellular Mechanics and Interactions
- Molecular Junctions and Nanostructures
- 3D Printing in Biomedical Research
- Adhesion, Friction, and Surface Interactions
- Osteoarthritis Treatment and Mechanisms
- Astro and Planetary Science
- Mechanical and Optical Resonators
- Electrical Contact Performance and Analysis
- Force Microscopy Techniques and Applications
- Cancer Cells and Metastasis
- Proteoglycans and glycosaminoglycans research
- Hematopoietic Stem Cell Transplantation
- Bone and Dental Protein Studies
- Solar Thermal and Photovoltaic Systems
- Geochemistry and Geologic Mapping
- Semiconductor Lasers and Optical Devices
- Carbon dioxide utilization in catalysis
- Photovoltaic System Optimization Techniques
- Wound Healing and Treatments
- Catalysis for Biomass Conversion
- Supramolecular Self-Assembly in Materials
- Collagen: Extraction and Characterization
- Photovoltaic Systems and Sustainability
- Cell Adhesion Molecules Research
- Eosinophilic Esophagitis
University of Glasgow
2000-2024
Applied Science Private University
2022
University of Cincinnati
2022
University of York
2017-2020
Sandia National Laboratories California
2018-2020
Northwestern University
2017
North Carolina State University
2010-2012
University of Chicago
2011
Sandia National Laboratories
2010
Northeastern University
2010
The design of hydrogels as mimetics tissues' matrices typically disregards the viscous nature native tissues and focuses only on their elastic properties. In case stem cell chondrogenesis, this has led to contradictory results, likely due unreported changes in matrices' modulus. Here, by employing isoelastic with Young's modulus ≈12 kPa, variations properties alone (i.e., loss tangent between 0.1 0.25) are demonstrated be sufficient drive efficient growth factor-free chondrogenesis human...
Secreted Protein Acidic and Rich in Cysteine (SPARC) is one of the major non-structural proteins extracellular matrix (ECM) remodeling tissues. The functional significance SPARC emphasized by its origin first multicellular organisms high degree evolutionary conservation. Although has been shown to act as a critical modulator ECM with profound effects on tissue physiology architecture, no plausible molecular mechanism action proposed. In present study, we demonstrate that mediates disassembly...
Contact resistance measurements are reported for radio frequency microelectromechanical system switches operating in an ultrahigh vacuum equipped with situ oxygen plasma cleaning capabilities. Ru-based contacts were prepared by means of standard sputtering techniques, followed postdeposition oxidation, (surface RuO2) or reactive the presence (bulk RuO2). In lowered Ru two more orders magnitude but not lower than Au contacts, irrespective whether cleaned. The time dependence was fit to power...
We report here a method of making polyketones from the coupling diketones and diols using manganese pincer complex. The methodology allows us to access various (polyarylalkylketone) containing aryl, alkyl, ether functionalities, bridging gap between two classes commercially available polyketones: aliphatic polyaryletherketones. Using this methodology, 12 have been synthesized characterized analytical techniques understand their chemical, physical, morphological, mechanical properties. Based...
Nanoparticles could conceal bioactive proteins during therapeutic delivery, avoiding side effects. Superparamagnetic iron oxide nanoparticles (SPIONs) coated with a temperature-sensitive polymer were tested for protein release. We show that SPIONs can entrap test and release them in temperature-controlled manner biological system. Magnetically heating triggered at bulk solution temperatures below the transition. The entrapped growth factor Wnt3a was inactive until magnetically release, upon...
The extracellular matrix (ECM) is a complex fibrillar network that couples cell with its environment and directly regulates cells’ functions via structural, mechanical, biochemical signals. goal of this study was to engineer characterize ECM-mimicking protein platforms material properties covering both physiological pathological (tumorous) tissues. We designed fabricated three-dimensional (3D) scaffolds comprising the two major components ECM, namely collagen (Col) fibronectin (Fn), using...
Glycans are inherently heterogeneous, yet glycosylation is essential in eukaryotes, and glycans show characteristic cell type-dependent distributions. By using an immortalized human mesenchymal stromal (MSC) line model, we that both N- O-glycan processing the Golgi functionally modulates early steps of osteogenic differentiation. We found inhibiting prior to start osteogenesis inhibited mineralization capacity formed osteoblasts 3 weeks later. In contrast, inhibition N-glycan MSCs altered...
We show how to control the formation and alignment of gel 'noodles'. Nanostructure can be achieved reproducibly by extensional deformation as filaments form. Using a spinning technique, very long highly aligned made. The Young's moduli noodles are similar that bulk gel. By using two syringe pumps in concentric flow setup, we filament-in-filament morphology created.
Abstract The design of hydrogels as mimetics tissues’ matrices typically disregards the viscous nature native tissues and focuses only on their elastic properties. In case stem cell chondrogenesis, this has led to contradictory results, likely due unreported changes matrices’ modulus. Here, by employing isoelastic with a Young’s modulus ~12 kPa, we demonstrate that variations in properties alone (i.e., loss tangent between 0.1-0.25) are sufficient drive efficient growth factor-free...
A series of experiments were performed in vacuum environments to investigate the impact rf micromechanical system switch contact voltage versus resistance for gold-on-gold contacts at cryogenic temperatures. The purpose this work was twofold as follows: (1) examine whether asperity heating models already validated high temperature also applicable temperatures and (2) explore implications validity prior suggestions that between 338 373 K are enough dissociate adsorbed film and/or push them...
We report here a new method to make polyketones from the coupling of diketones and diols using manganese pincer complex. The methodology allows us access type polyketone (polyarylalkylketone) containing aryl, alkyl, ether functionalities bridging gap between two classes commercially available – aliphatic polyaryletherketones. Using this methodology, twelve have been synthesized characterised various analytical techniques understand their chemical, physical, morphological, mechanical...
A method has been developed for release/isolation of O-glycans from glycoproteins in whole cell lysates mass spectrometric analysis. Cells are lysed SDS, which is then exchanged urea and ammonium bicarbonate a centrifugal filter, before treating with NH4OH to release O-glycans. Following centrifugation, recovered the filtrate. Sonication achieves O-glycan 1 h. Combining established protocol filter-aided N-glycan separation, here optimized enhanced PNGase F efficiency, allows analysis both N-...
Electrical contact resistance measurements are reported for RF micro-electromechanical switches situated within an ultrahigh vacuum system equipped with in situ oxygen plasma cleaning capabilities. Measurements were performed on fused (permanently adhered) Au/Au contacts and functioning Au/RuO2 both the presence absence of adsorbed monolayers pentane dodecane. For adhered closed position, adsorption occurs only regions external to direct contact. switches, however, it can occur either or...
A quartz crystal microbalance (QCM) with a graphene/Ni(111) electrode has been used to probe frictional heating effects in Kr monolayers sliding on the response its oscillatory motion. The temperatures of are observed rise approximately 13 K higher than their static counterparts, but show surprisingly little dependence oscillation amplitude. Although counterintuitive, observation can be explained by noting that surface residence times limited, which effectively caps how much temperature rise.
We report here the application of polyetherureas as a new class aqueous binder for LiFePO4 positive electrode material in lithium-ion batteries. Polyetherureas have been synthesized using greener route (avoiding conventionally used toxic diisocyanate feedstock) by ruthenium-catalysed dehydrogenative coupling polyethylene glycol diamine and methanol. The best performance was obtained when polyetherurea combination with SBR (Styrene-Butadiene Rubber) exhibiting an initial coulombic efficiency...