A5035675746- Neuroscience of respiration and sleep
- Autopsy Techniques and Outcomes
- Glioma Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Renal and related cancers
- Restraint-Related Deaths
- Pregnancy and preeclampsia studies
- Injury Epidemiology and Prevention
- Immunodeficiency and Autoimmune Disorders
- Cancer, Hypoxia, and Metabolism
- Blood groups and transfusion
- Neuroblastoma Research and Treatments
- Advanced Proteomics Techniques and Applications
- Metabolism and Genetic Disorders
- Prenatal Screening and Diagnostics
- ATP Synthase and ATPases Research
- Child and Adolescent Health
- Sarcoma Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- Cancer Mechanisms and Therapy
- Connective tissue disorders research
- Automotive and Human Injury Biomechanics
- Childhood Cancer Survivors' Quality of Life
- COVID-19 and healthcare impacts
St George’s University Hospitals NHS Foundation Trust
2020-2024
St George's Hospital
2021
St George's Hospital
2019
Great Ormond Street Hospital
2011-2017
University College London
2011-2017
Great Ormond Street Hospital for Children NHS Foundation Trust
2015
University College Lahore
2014
National Institute for Health Research
2013
Institute of Child Health
2012
Queen Mary University of London
2010
Finding an inherited complement abnormality in HSCT-associated TMA provides a rationale for the use of inhibitor.Alternative inhibitors such as Coversin should be considered patients who are resistant to eculizumab.
ABSTRACT Objectives Maternal mortality related to placenta accreta spectrum (PAS) disorders remains substantial when diagnosed unexpectedly at delivery. The aim of this study was evaluate the effectiveness a routine contingent ultrasound screening program for PAS. Methods This retrospective data obtained between 2009 and 2019, involving two groups: cohort unselected women attending mid‐trimester assessment diagnostic consisting referred PAS service with suspected diagnosis In cohort,...
Infancy is the most common period for childhood death, including both neonatal deaths from obstetric or medical complications and sudden unexpected infant deaths. The weighing of organs at autopsy an established process recommended in current protocols. However, minimal contemporary data available regarding reference ranges organ weights infants. Organ weight consecutive autopsies over a 14 year performed single tertiary centre, >1,000 cases, were examined order to provide up date across...
Somatic mutations in ACVR1 are found a quarter of children with diffuse intrinsic pontine glioma (DIPG), but there no inhibitors licensed for the disease. Using an artificial intelligence-based platform to search approved compounds ACVR1-mutant DIPG, combination vandetanib and everolimus was identified as possible therapeutic approach. Vandetanib, inhibitor VEGFR/RET/EGFR, target (K d = 150 nmol/L) reduce DIPG cell viability vitro has limited ability cross blood-brain barrier. In addition...
Aim Tandem mass spectrometry (MS/MS) is a recommended investigation for sudden unexpected death in infancy (SUDI), but there are limited data regarding yield and potential influencing factors. This study investigates postmortem acylcarnitine profiles large cohort of infant deaths from single centre, including those with metabolic disease. Methods Acylcarnitine results obtained by MS/MS routine blood/bile spot samples during the standard autopsy were identified over 14-year period. Results...
Aim Pathologists currently follow the ‘Kennedy guidelines’ when performing autopsies for sudden unexpected death in infancy (SUDI); these include extensive histological sampling. This study establishes frequency with which examination of visceral organs determines cause and examines associations between clinical, macroscopic microscopic findings. Methods Retrospective review 546 SUDI performed a 10-year period (1996–2005) at single centre. The proportion cases non-neuropathological directly...
Post-mortem (PM) microbiological investigations are recommended in cases of sudden unexpected death infancy (SUDI), and infection is a recognised cause such deaths, but no current evidence-based guidelines exist for the appropriate interpretation results.To assess interpretive difficulties using targeted cross-specialty questionnaire.109 consultant specialists involved infant management were given questionnaire providing information on five hypothetical standardised SUDI cases, which...
Purpose: To investigate the frequency, circumstances, demographics and autopsy findings of infants children dying as a result foreign body aspiration. Methods: Retrospective review cases in aged between seven days 18 years, at one specialist centre over 16-year period, which death was aspiration body. Results: Ten were identified out total population 2165. Only individual had an underlying diagnosis potentially contributing to All but case involved food, with grapes being feature four cases....
Sudden unexpected death in infancy (SUDI) represents the commonest presentation of post-neonatal infant UK. This audit reviews current practice investigation SUDI deaths, with particular regard to microbiological sampling emergency departments (ED) compared samples obtained at time autopsy for establishing cause death, as suggested by guidelines.Coronial autopsies performed indication over a 4-year period single specialist centre were reviewed findings investigations ED those autopsy.Of 229...
Published reports of brain weight in sudden infant death syndrome (SIDS) are contradictory, although several have concluded that is increased SIDS compared with controls or reference data. This important as, if significantly different, it may be diagnostic use provide insights into the aetiology SIDS. The aim this study was to a large series well-characterized unexpected deaths from single centre definitive data regarding issue.A retrospective review identified 1100 infants who had died...
Current guidelines for the investigation of sudden unexpected death in infancy (SUDI) include full neuropathological examination with recommendations brain fixation 1-2 weeks. Little evidence is available regarding yield such determining cause clinical practice. This study examines frequency findings at postmortem SUDI relation to and macroscopic features.All examinations performed indication a single specialist centre over 14-year period were reviewed, including history, findings.6% cases...
Aims Sudden unexpected death in infancy (SUDI) investigation requires extensive ancillary investigations, the results of which, such as postmortem microbiology, can be difficult to interpret. Markers an inflammatory response, including interleukin 6 (IL-6), c-reactive protein (CRP) and cellular adhesion molecules are elevated infections, yet little attention has been paid their assessment after death. This study investigates role markers SUDI autopsies for determining cause Methods Cases...
Objectives Infant mortality has undergone a dramatic reduction in the UK over past century because of improvements public health policy and medical advances. Postmortem examinations have been performed at Great Ormond Street Hospital for 100 years, analysis cases across this period to assess changing patterns infant deaths undergoing autopsy. Design Autopsy reports from 1909 2009 were examined. Age, major pathology cause death was reviewed these entered into an anonymized database. A...
Sudden unexpected death in infancy and childhood attributable to undiagnosed neoplasia is rare. Malignant neoplasms are very uncommon infancy, with an age-standardized incidence rate of 118.3 per million. Primary malignant liver tumors rare, hepatoblastoma accounting for up two thirds cases. Although the most common neoplasm childhood, it only accounts 3.1% cancers infants less than 12 months age. We describe first case sudden apparently healthy 6-month-old infant whose autopsy revealed...
Aim: Cardiomyopathy, a group of primary myocardial disorders, is an uncommon, but important, cause death in childhood. This study examines the demographic, clinical and pathological features fatal cardiomyopathy childhood with particular reference to its classification autopsy findings. Method: The method this was retrospective structured review all paediatric autopsies performed at single specialist centre from 1995 2009 inclusive, order determine cardiomyopathy. Results: From total 2229...
Familial neuroblastoma is an extremely rare entity with only 1 – 2% of cases thought to have a familial inheritance, mainly due PHOX2B and ALK germline mutations. 16p11.2 microdeletion syndrome has been reported be associated neuroblastoma. We present the first case report patient presenting metastatic neuroblastoma, developmental delay, atypical facies, in whom we identified inherited microdeletion.